The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL159332     N-methyl-1-[3-[[(2R)-1- methylpyrrolidin-2...

Synonyms: SureCN7103413, AC1Q6VPO, AR-1C3711, CP-122288, LS-173170, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CP 122288


High impact information on CP 122288


Chemical compound and disease context of CP 122288


Biological context of CP 122288

  • 4. In a separate series of studies in the anaesthetized rat, CP-122,288 (0.003-3 micrograms kg-1 i.v.) produced no change in either heart rate or mean arterial blood pressure, thus demonstrating that doses of CP-122,288 which inhibit plasma protein leakage in rat dura, are devoid of hemodynamic effects [2].

Anatomical context of CP 122288


Associations of CP 122288 with other chemical compounds

  • The failing soldiers have included the NK-1 antagonists, some second-generation 5-HT(1B/1D) agonists, CP-122,288, 4991W93, the neurosteroid ganaxolone, selective 5-HT(1F) (LY334370) and 5-HT(1D) agonists (PNU-142,633), and the endothelin-1 antagonist bosentan [9].

Analytical, diagnostic and therapeutic context of CP 122288


  1. No acute antimigraine efficacy of CP-122,288, a highly potent inhibitor of neurogenic inflammation: results of two randomized, double-blind, placebo-controlled clinical trials. Roon, K.I., Olesen, J., Diener, H.C., Ellis, P., Hettiarachchi, J., Poole, P.H., Christianssen, I., Kleinermans, D., Kok, J.G., Ferrari, M.D. Ann. Neurol. (2000) [Pubmed]
  2. The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation. Gupta, P., Brown, D., Butler, P., Ellis, P., Grayson, K.L., Land, G.C., Macor, J.E., Robson, S.F., Wythes, M.J., Shepperson, N.B. Br. J. Pharmacol. (1995) [Pubmed]
  3. 5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors. Yu, X.J., Waeber, C., Castanon, N., Scearce, K., Hen, R., Macor, J.E., Chauveau, J., Moskowitz, M.A., Chaveau, J. Mol. Pharmacol. (1996) [Pubmed]
  4. The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. Yu, X.J., Cutrer, F.M., Moskowitz, M.A., Waeber, C. Neuropharmacology (1997) [Pubmed]
  5. Conformationally restricted sumatriptan analogues, CP-122,288 and CP-122,638 exhibit enhanced potency against neurogenic inflammation in dura mater. Lee, W.S., Moskowitz, M.A. Brain Res. (1993) [Pubmed]
  6. Suppression by the sumatriptan analogue, CP-122,288 of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin. Cutrer, F.M., Schoenfeld, D., Limmroth, V., Panahian, N., Moskowitz, M.A. Br. J. Pharmacol. (1995) [Pubmed]
  7. The pre- and postjunctional activity of CP-122,288, a conformationally restricted analogue of sumatriptan. Beattie, D.T., Connor, H.E. Eur. J. Pharmacol. (1995) [Pubmed]
  8. Autoradiographic visualisation of [3H]5-carboxamidotryptamine binding sites in the guinea pig and rat brain. Waeber, C., Moskowitz, M.A. Eur. J. Pharmacol. (1995) [Pubmed]
  9. Acute treatments: some blind alleys. Ramadan, N.M. Current medical research and opinion. (2001) [Pubmed]
WikiGenes - Universities