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Chemical Compound Review

DHCDA     (2R,3R,4S,5R)-2-(5-amino- 4,7,9...

Synonyms: Deaza-Ado, CHEMBL202701, C^3Ado, AG-J-16379, SureCN1738519, ...
 
 
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Disease relevance of Deaza-Ado

 

High impact information on Deaza-Ado

 

Biological context of Deaza-Ado

 

Anatomical context of Deaza-Ado

 

Gene context of Deaza-Ado

 

Analytical, diagnostic and therapeutic context of Deaza-Ado

  • Use of anti-(tumour necrosis factor-alpha) antibody or 3-deaza-adenosine as additives to promote protection by University of Wisconsin solution in ischaemia/reperfusion injury [9].

References

  1. 3-Deaza-adenosine and inhibition of HIV. Flexner, C.W., Hildreth, J.E., Kuncl, R.W., Drachman, D.B. Lancet (1992) [Pubmed]
  2. Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth. Long, M.C., Allan, P.W., Luo, M.Z., Liu, M.C., Sartorelli, A.C., Parker, W.B. J. Antimicrob. Chemother. (2007) [Pubmed]
  3. The effect of pharmacologic inhibition of phospholipid methylation on human platelet function. Shattil, S.J., Montgomery, J.A., Chiang, P.K. Blood (1982) [Pubmed]
  4. Regulation of epithelial Na+ channels (ENaC) by methylation: a novel methyltransferase stimulates ENaC activity. Edinger, R.S., Yospin, J., Perry, C., Kleyman, T.R., Johnson, J.P. J. Biol. Chem. (2006) [Pubmed]
  5. Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution. Pintucci, G., Quarto, N., Rifkin, D.B. Mol. Biol. Cell (1996) [Pubmed]
  6. Modulation of the biologic activities of IgE-binding factors. VII. Biochemical mechanisms by which glycosylation-enhancing factor activates phospholipase in lymphocytes. Akasaki, M., Iwata, M., Ishizaka, K. J. Immunol. (1985) [Pubmed]
  7. Paradoxical effects of adenosine on neutrophil chemotaxis. Garcia-Castro, I., Mato, J.M., Vasanthakumar, G., Wiesmann, W.P., Schiffmann, E., Chiang, P.K. J. Biol. Chem. (1983) [Pubmed]
  8. Kinetic properties of the common electrophoretic variants of human S-adenosylhomocysteine hydrolase (AHCY): the effect of four nucleoside analogue inhibitors. Corbo, R.M., Ingianna, R., Scacchi, R., Bozzi, A. Ann. Hum. Genet. (1992) [Pubmed]
  9. Use of anti-(tumour necrosis factor-alpha) antibody or 3-deaza-adenosine as additives to promote protection by University of Wisconsin solution in ischaemia/reperfusion injury. Chiang, C.H., Wu, C.P., Perng, W.C., Yan, H.C., Yu, C.P. Clin. Sci. (2000) [Pubmed]
  10. DNA (cytosine) methylation in murine and human tumor cell lines treated with S-adenosylhomocysteine hydrolase inhibitors. Liteplo, R.G. Cancer Lett. (1988) [Pubmed]
  11. Interaction of 3-deaza-adenosine, a phospholipid methyltransferase inhibitor, on the production of pluripoietins from human peripheral T cells. Fauser, A.A., Cooper, B.A., Kanz, L., Löhr, G.W. Exp. Hematol. (1985) [Pubmed]
  12. Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin. Abbruzzese, J.L., Frost, P. Cancer Chemother. Pharmacol. (1992) [Pubmed]
  13. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Gordon, R.K., Ginalski, K., Rudnicki, W.R., Rychlewski, L., Pankaskie, M.C., Bujnicki, J.M., Chiang, P.K. Eur. J. Biochem. (2003) [Pubmed]
  14. 3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors. Costanzi, S., Lambertucci, C., Volpini, R., Vittori, S., Lupidi, G., Cristalli, G. Nucleosides Nucleotides Nucleic Acids (2001) [Pubmed]
 
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