Disease relevance of C12525

• Tritiated 5alpha-androstane-3alpha,17beta-diol (3alpha-diol) and 5alpha-androstane-3beta,17beta-diol (3beta-diol) respectively were administered to patients with benign prostatic hypertrophy (bph) undergoing prostatectomy [1].

High impact information on C12525

• An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth [2].
• When NADPH was cofactor, the formation of 3alpha- and 3beta-androstanediol was significantly higher in microsomes and cytosol from hypertrophic than from normal glands [3].
• The 3-keto reduction of (1.2-3H)dihydrotestosterone to 3alpha and 3beta-androstanediol has been assessed in homogenates of 31 dog prostates that varied in size from less than 1 to greater than 15 g [4].
• These parameters pertain to (1) kinetics of androgen binding, (2) metabolism of 5alpha-dihydrotestosterone (DHT), 5alpha-androstane-3alpha,17beta-diol (3alpha-diol) and 5alpha-androstane-3beta,17beta-diol (3beta-diol), (3) ornithine decarboxylase (ODC) activity and (4) interleukin-1alpha (IL-1alpha) action on cell proliferation [5].
• The androgenic potencies of testosterone, 5alpha-dihydrotestosterone, 5alpha-androstane-3alpha,17beta-diol and 5alpha-androstane-3beta,17beta-diol towards the prostate, glandula seminalis+glandula vesicularis, ampullae and epididymis were evaluated after administration to castrated rabbits [6].

Biological context of C12525

• 4-Androstene-3,17-dione, 5alpha-androstan-3alpha,17beta-diol and 5alpha-androstan-3beta,17beta-diol had no significant effect on cell proliferation at a concentration of 10(-7) M, while 4-androstene-3beta,17beta-diol augmented cell number to values 50-60% higher than those of control cultures [7].
• No cross reactions were observed with 5alpha-androstane-3beta,17beta-diol and 5-androstene-3beta,17beta-diol [8].

Anatomical context of C12525

• In the cerebral cortex 5alpha-androstane-3,17-dione was the most abundant metabolite, whereas 5alpha-androstane-3,17-dione, 5alpha-androstane-3alpha,17beta-diol, and 5alpha-androstane-3beta,17beta-diol were all present in equivalent amounts in the hypothalamus and pituitary [9].
• With 3 beta,17 beta-dihydroxy-5 alpha-androstane as substrate the highest enzyme activities were measured in PAT and gonad homogenates from animals of all investigated life stages [10].
• Conversion of progesterone to 5alpha-reduced 17-hydroxy-C21 and C19-steroids such as 3alpha,17alpha-dihydroxy-5alpha-pregnan-20-one, androsterone, 5alpha-androstane-3alpha,17beta-diol and 5alpha-androstane-3beta,17beta-diol was high in testes of 28- and 35-day-old mice of both groups [11].

Associations of C12525 with other chemical compounds

• With NADP a higher HSD-dependent HSD activity was detected in presumed adrenocortical tissue (PAT) homogenates with pregnenolone and 3 beta,17 beta-dihydroxy-5 alpha-androstane and in gonad homogenates only with 3 beta,17 beta-dihydroxy-5 alpha-androstane [10].

Gene context of C12525

• 3alpha- and 3beta-androstanediol were similarly assayed using human TeBG (sensitivity approximately 150 pg) [12].
• Effects of 6- and 7-hydroxy metabolites of 3 beta,17 beta-dihydroxy-5 alpha-androstane on gonadotrophin and prolactin secretion and on sex accessories weight of male rats [13].

Analytical, diagnostic and therapeutic context of C12525

• The effect of 3beta-androstanediol on inducing precocious vaginal opening was found to be mediated by the ovaries, since it was eliminated by ovariectomy [14].
• Concentrations of unconjugated 5alpha-androstan-3beta,17beta-diol in human peripheral plasma as measured by radioimmunoassay [15].

References