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Chemical Compound Review

Hombreol     (3R,5S,8R,9S,10S,13S,14S,17S)- 10,13...

Synonyms: ANDROSTANDIOL, CHEMBL335062, SureCN869146, A7755_SIGMA, CHEBI:36713, ...
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Disease relevance of Hombreol


High impact information on Hombreol


Chemical compound and disease context of Hombreol


Biological context of Hombreol


Anatomical context of Hombreol


Associations of Hombreol with other chemical compounds


Gene context of Hombreol


Analytical, diagnostic and therapeutic context of Hombreol


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  3. Virilization of the urogenital sinus of the tammar wallaby is not unique to 5alpha-androstane-3alpha,17beta-diol. Leihy, M.W., Shaw, G., Wilson, J.D., Renfree, M.B. Mol. Cell. Endocrinol. (2001) [Pubmed]
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  6. Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol. Shaw, G., Renfree, M.B., Leihy, M.W., Shackleton, C.H., Roitman, E., Wilson, J.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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  13. SHBG Gene Promoter Polymorphisms in Men Are Associated with Serum Sex Hormone-Binding Globulin, Androgen and Androgen Metabolite Levels, and Hip Bone Mineral Density. Eriksson, A.L., Lorentzon, M., Mellstr??m, D., Vandenput, L., Swanson, C., Andersson, N., Hammond, G.L., Jakobsson, J., Rane, A., Orwoll, E.S., Ljunggren, O., Johnell, O., Labrie, F., Windahl, S.H., Ohlsson, C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
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  15. Changes in serum concentration and ovarian content of 5 alpha-androstane-3 alpha,17 beta-diol in the female rat approaching first ovulation. Meijs-Roelofs, H.M., Kramer, P., v Cappellen, W.A., Woutersen, P.J. Biol. Reprod. (1985) [Pubmed]
  16. Multiple forms of cytochrome P-450 in rat-liver microsomes. Separation and some properties of different hydroxylases active on free and sulphoconjugated steroids. Gustafsson, J.A., Ingleman-Sundberg, M.I. Eur. J. Biochem. (1976) [Pubmed]
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  19. Aging and tissue androgens. Deslypere, J.P., Vermeulen, A. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
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  21. Androstane-3alpha,17beta-diol glucuronide as a steroid correlate of visceral obesity in men. Tchernof, A., Labrie, F., Bélanger, A., Prud'homme, D., Bouchard, C., Tremblay, A., Nadeau, A., Després, J.P. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  22. Formation and secretion of 5alpha-androstan-17beta-ol-3-one, 5alpha-androstan-3alpha,17beta-diol and 5alpha-androstan-3beta,17beta-diol by the perfused rabbit testis epididymis. Ewing, L., Brown, B. Endocrinology (1975) [Pubmed]
  23. Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens. Narula, A., Gu, Y.Q., O'Donnell, L., Stanton, P.G., Robertson, D.M., McLachlan, R.I., Bremner, W.J. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  24. The marsupial model for male phenotypic development. Wilson, J.D., Shaw, G., Leihy, M.L., Renfree, M.B. Trends Endocrinol. Metab. (2002) [Pubmed]
  25. Dehydroepiandrosterone replacement administration: pharmacokinetic and pharmacodynamic studies in healthy elderly subjects. Legrain, S., Massien, C., Lahlou, N., Roger, M., Debuire, B., Diquet, B., Chatellier, G., Azizi, M., Faucounau, V., Porchet, H., Forette, F., Baulieu, E.E. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  26. Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients. Boudou, P., Soliman, H., Chivot, M., Villette, J.M., Vexiau, P., Belanger, A., Fiet, J. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  27. Plasma levels of 5alpha-androstane-3alpha,17beta-diol in boys during adolescent growth. Klemm, W., Liebich, H.M., Gupta, D. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  28. Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism. Ji, Q., Chang, L., VanDenBerg, D., Stanczyk, F.Z., Stolz, A. Prostate (2003) [Pubmed]
  29. Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Lévesque, E., Beaulieu, M., Hum, D.W., Bélanger, A. Pharmacogenetics (1999) [Pubmed]
  30. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. Chen, F., Ritter, J.K., Wang, M.G., McBride, O.W., Lubet, R.A., Owens, I.S. Biochemistry (1993) [Pubmed]
  31. Requirement for heparan sulphate proteoglycans to mediate basic fibroblast growth factor (FGF-2)-induced stimulation of Leydig cell steroidogenesis. Laslett, A.L., McFarlane, J.R., Hearn, M.T., Risbridger, G.P. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  32. Urinary 5 alpha-androstane-3 alpha,17 beta-diol radioimmunoassay: a new clinical evaluation. Wright, F., Mowszowicz, I., Mauvais-Jarvis, P. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  33. 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate. Wilson, J.D., Auchus, R.J., Leihy, M.W., Guryev, O.L., Estabrook, R.W., Osborn, S.M., Shaw, G., Renfree, M.B. Endocrinology (2003) [Pubmed]
  34. Analgesic effects of the neurosteroid 3 alpha-androstanediol. Frye, C.A., Van Keuren, K.R., Rao, P.N., Erskine, M.S. Brain Res. (1996) [Pubmed]
  35. The neurosteroid, 3alpha-androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats. Frye, C.A., McCormick, C.M. Brain Res. (2000) [Pubmed]
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