Disease relevance of hydrazine hydrate

• Acute toxicity of hydrazine hydrate to the fathead minnow (Pimephales promelas) and daphnid (Daphnia pulex) [1].

High impact information on hydrazine hydrate

• Reducing Cu(OH)4(2-) with hydrazine hydrate and glucose in the presence of a structure-directing surfactant at room temperature gave Cu and Cu2O nanotubes/nanorods, respectively, whereas facile hydrothermal treatment of Cu(OH)4(2-) precursor resulted in CuO nanotubes/nanorods [2].
• Structural analyses were undertaken after partial hydrogenation of their concentrates with hydrazine hydrate and subsequent isolation of the monoenoate products by argentation thin-layer chromatography [3].
• Four other hydrazine compounds, hydrazine hydrate (HZH), phenylhydrazine (PHZ), hydralazine (HLZ) and nialamide (NLD), were mutagenic in WP2 uvrA/pKM101 [4].
• Treatment of the conjugates with hydrazine hydrate, however, resulted in complete hydrolysis of the glucuronic acid conjugates as well as in reduction to the parent amine of metabolites hydroxylated in the exocyclic amino group [5].
• The chemical hydrolysis of glucuronide conjugates of PhIP metabolites with hydrazine hydrate observed in this study may also be a useful approach in the development of biomarkers for exposure and effect of other xenobiotics [5].

Biological context of hydrazine hydrate

• The data show that hydrazine hydrate can hydrolyse N-glucuronides of metabolites of PhIP, glucuronides that are unsusceptible to enzymatic hydrolysis [5].
• The regioselective glycosylation of 12 (derived by O-debenzoylation of 11) with 7 gave the heptasaccharide 13, which was converted by treatment with hydrazine monohydrate and subsequent N-acetylation into the hexasaccharide acceptor 14 [6].
• Aminofentanyl which represents a structural derivative of fentanyl has been synthesized by acylation of 1-(2-phenethyl)-4-(N-anilino)piperidine with phthaloyl protected beta-alaninyl chloride in the presence of DIPEA, followed by deprotection with hydrazine hydrate [7].
• Likewise, when potassium dithiocarbazate--prepared from nicotinic acid hydrazide--was reacted with hydrazine hydrate, cyclization and production of 4-amino-3-(3-pyridyl)-5-mercapto[4H]-1,2,4-triazole was achieved [8].
• Friedel Craft's acetylation of 1b yielded the 5-acetyl derivative (6), which reacted with hydrazine hydrate, o-toluidine and o-aminophenol to afford (7a-c) [9].

Associations of hydrazine hydrate with other chemical compounds

• This synthesis method is based on reverse micelle technique using Igepal CO-520 as a surfactant and the mixed solution of silver nitrate and rhodamine dyes with isothiocyanate group as water pool followed by hydrazine hydrate reduction and TEOS polymerization leading to the formation of silica layer surrounding the silver core [10].
• Hydrazones of glucose and N-acetylglucosamine were prepared by reaction with hydrazine hydrate, and successfully reacted with isothiocyanate-substituted polystyrene by incubation at room temperature and neutral pH [11].
• Biological specimens for scanning electron microscopy are made electron-conductive and non-charging by intense osmication with tannic acid, thiocarbohydrazide, hydrazine hydrate or other bifunctional ligands (or mordants) [12].
• Cyclization of the chalcones with hydrazine hydrate or monosubstituted hydrazines afforded 1.3.5 trisubstituted 2-pyrazoline[13]

Gene context of hydrazine hydrate

• A cross-sectional observation of the health effects of hydrazine hydrate and differences of its metabolism by NAT2 polymorphism [14].
• Meta-nitroaniline (m-NA) doped silver/poly(vinylalcohol) (Ag/PVA) nanocomposites are prepared via in-situ reduction of silver salt by employing hydrazine hydrate (HH) in order to study the effect of the NLO active m-NA on the optical properties of nanoparticles of silver in the colloidal as well as self supported film form [15].
• OBJECTIVES: To summarize the results of two studies that attempted to clarify: (1) the health effects of hydrazine hydrate (HH) (N2H4 x H2O: CAS No. 7803-57-8); and (2) the influence of allelic polymorphism of N-acetyltransferase (NAT2) on the metabolism of HH [14].

Analytical, diagnostic and therapeutic context of hydrazine hydrate

• A Georgia kaolinite was separated into nine size fractions and their intercalations by hydrazine monohydrate and potassium acetate were investigated with X-ray diffraction (XRD) and Fourier-transform infrared (FTIR) analyses [16].

References