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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Daphnia

  • Of the four known globin genes that exist in the fresh-water crustacean Daphnia magna, several are individually induced by hypoxia, lending pale normoxic animals a visible red color when challenged by oxygen deprivation [1].
  • This program comprised acute toxicity studies on nine representative species of aquatic life, chronic reproduction studies on Daphnia magna, biodegradation (fate) testing, and physicochemical property (mobility) determinations on 14 phthalate esters [2].
  • By supplementation of single-lipid compounds in controlled growth experiments, we show here that the low C transfer efficiency of coccal and filamentous cyanobacteria to the keystone herbivore Daphnia is caused by the low sterol content in cyanobacteria, which constrains cholesterol synthesis and thereby growth and reproduction of the herbivore [3].
  • The effect of both the alkyl (10 and 12 carbon atoms) and the spacer chain (from 2-10 methylene groups) of bis(Args) on their antimicrobial activity, acute toxicity on Daphnia magna and Photobacterium phosphoreum, and aerobic biodegradability is studied [4].
  • Life-history characteristics of Daphnia exposed to dissolved microcystin-LR and to the cyanobacterium Microcystis aeruginosa with and without microcystins [5].

High impact information on Daphnia


Chemical compound and disease context of Daphnia


Biological context of Daphnia


Anatomical context of Daphnia


Associations of Daphnia with chemical compounds

  • Temperature-dependent effects of cadmium on Daphnia magna: accumulation versus sensitivity [9].
  • The freshwater cladoceran Daphnia pulex was explored as an alternative to Artemia salina for the biological screening of phytochemicals [21].
  • Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna [22].
  • In the present study, we demonstrate that two responses to environmental stress signaling in the crustacean Daphnia magna--hemoglobin accumulation and male offspring production--are co-elevated by the crustacean terpenoid hormone methyl farnesoate and several synthetic analogs [23].
  • Uptake and elimination routes of inorganic mercury and methylmercury in Daphnia magna [24].

Gene context of Daphnia

  • A 3667-base pair (bp) fragment of the mitochondrial genome of the crustacean Daphnia pulex has been sequenced and found to contain the complete genes for the small subunit ribosomal RNA, ND2, seven tRNAs and the control region [25].
  • The Daphnia Magna test for final residual TOC does not reveal anytoxic behavior [26].
  • Daphnia magna showed high sensitivity to both toxicants, whereas L. quadridentata was highly resistant to DDT and less susceptible to Mn [27].
  • Cytochrome B gene partial sequence and RAPD analysis of two Daphnia longispina lineages differing in their resistance to copper [28].

Analytical, diagnostic and therapeutic context of Daphnia


  1. Hypoxia-induced synthesis of hemoglobin in the crustacean Daphnia magna is hypoxia-inducible factor-dependent. Gorr, T.A., Cahn, J.D., Yamagata, H., Bunn, H.F. J. Biol. Chem. (2004) [Pubmed]
  2. Environmental fate and aquatic toxicology studies on phthalate esters. Group, E.F. Environ. Health Perspect. (1986) [Pubmed]
  3. Absence of sterols constrains carbon transfer between cyanobacteria and a freshwater herbivore (Daphnia galeata). von Elert, E., Martin-Creuzburg, D., Le Coz, J.R. Proc. Biol. Sci. (2003) [Pubmed]
  4. Biological properties of arginine-based gemini cationic surfactants. Pérez, L., García, M.T., Ribosa, I., Vinardell, M.P., Manresa, A., Infante, M.R. Environ. Toxicol. Chem. (2002) [Pubmed]
  5. Life-history characteristics of Daphnia exposed to dissolved microcystin-LR and to the cyanobacterium Microcystis aeruginosa with and without microcystins. Lürling, M., van der Grinten, E. Environ. Toxicol. Chem. (2003) [Pubmed]
  6. Evolving role of Antennapedia protein in arthropod limb patterning. Shiga, Y., Yasumoto, R., Yamagata, H., Hayashi, S. Development (2002) [Pubmed]
  7. Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna. LeBlanc, G.A., Mu, X., Rider, C.V. Environ. Health Perspect. (2000) [Pubmed]
  8. Characterization of arsenic compounds formed by Daphnia magna and Tetraselmis chuii from inorganic arsenate. Irgolic, K.J., Woolson, E.A., Stockton, R.A., Newman, R.D., Bottino, N.R., Zingaro, R.A., Kearney, P.C., Pyles, R.A., Maeda, S., McShane, W.J., Cox, E.R. Environ. Health Perspect. (1977) [Pubmed]
  9. Temperature-dependent effects of cadmium on Daphnia magna: accumulation versus sensitivity. Heugens, E.H., Jager, T., Creyghton, R., Kraak, M.H., Hendriks, A.J., Van Straalen, N.M., Admiraal, W. Environ. Sci. Technol. (2003) [Pubmed]
  10. An assessment of the chronic toxicity of the synthetic pyrethroid, fenvalerate, to Daphnia galeata mendotae, using life tables. Day, K., Kaushik, N.K. Environ. Pollut. (1987) [Pubmed]
  11. Chronic toxicity of a pure and technical grade pentachlorophenol to Daphnia magna. Stephenson, G.L., Kaushik, N.K., Solomon, K.R. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  12. Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity. Mu, X., LeBlanc, G.A. Gen. Comp. Endocrinol. (2002) [Pubmed]
  13. Effect of ent-labdane diterpenes from Potamogetonaceae on Selenastrum capricornutum and other aquatic organisms. Cangiano, T., Dellagreca, M., Fiorentino, A., Isidori, M., Monaco, P., Zarrelli, A. J. Chem. Ecol. (2002) [Pubmed]
  14. The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna. Kast-Hutcheson, K., Rider, C.V., LeBlanc, G.A. Environ. Toxicol. Chem. (2001) [Pubmed]
  15. Effect of dissolved organic matter of various origins and biodegradabilities on the bioaccumulation of polycyclic aromatic hydrocarbons in Daphnia magna. Gourlay, C., Tusseau-Vuillemin, M.H., Garric, J., Mouchel, J.M. Environ. Toxicol. Chem. (2003) [Pubmed]
  16. Silver accumulation in Daphnia magna in the presence of reactive sulfide. Bianchini, A., Rouleau, C., Wood, C.M. Aquat. Toxicol. (2005) [Pubmed]
  17. Biotransformation and bioconcentration of pyrene in Daphnia magna. Akkanen, J., Kukkonen, J.V. Aquat. Toxicol. (2003) [Pubmed]
  18. Variation in the development of cadmium resistance in Daphnia magna straus; effect of temperature, nutrition, age and genotype. Stuhlbacher, A., Bradley, M.C., Naylor, C., Calow, P. Environ. Pollut. (1993) [Pubmed]
  19. The toxicity of the mutagen 'MX' and its analogue, mucochloric acid, to rainbow trout hepatocytes and gill epithelial cells and to Daphnia magna. Isomaa, B., Holmström, T.H., Lilius, H., Franzén, R., Kronberg, L. Toxicology (1995) [Pubmed]
  20. Biochemical and morphological comparison of microsomal preparations from rat, quail, trout, mussel, and water flea. Ade, P., Banchelli Soldaini, M.G., Castelli, M.G., Chiesara, E., Clementi, F., Fanelli, R., Funari, E., Ignesti, G., Marabini, A., Orunesu, M. Ecotoxicol. Environ. Saf. (1984) [Pubmed]
  21. Development of a bioassay for phytochemicals using Daphnia pulex. Morrow, D., Corrigan, D., Waldren, S. Planta Med. (2001) [Pubmed]
  22. Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna. Olmstead, A.W., LeBlanc, G.L. Toxicol. Sci. (2001) [Pubmed]
  23. Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean. Rider, C.V., Gorr, T.A., Olmstead, A.W., Wasilak, B.A., LeBlanc, G.A. J. Exp. Biol. (2005) [Pubmed]
  24. Uptake and elimination routes of inorganic mercury and methylmercury in Daphnia magna. Tsui, M.T., Wang, W.X. Environ. Sci. Technol. (2004) [Pubmed]
  25. Partial mitochondrial DNA sequence of the crustacean Daphnia pulex. Van Raay, T.J., Crease, T.J. Curr. Genet. (1994) [Pubmed]
  26. Degradation of imidacloprid in water by photo-Fenton and TiO2 photocatalysis at a solar pilot plant: a comparative study. Malato, S., Caceres, J., Agüera, A., Mezcua, M., Hernando, D., Vial, J., Fernández-Alba, A.R. Environ. Sci. Technol. (2001) [Pubmed]
  27. Effect of coexposure to DDT and manganese on freshwater invertebrates: pore water from contaminated rivers and laboratory studies. Mejía-Saavedra, J., Sánchez-Armass, S., Santos-Medrano, G.E., Gónzalez-Amaro, R., Razo-Soto, I., Rico-Martínez, R., Díaz-Barriga, F. Environ. Toxicol. Chem. (2005) [Pubmed]
  28. Cytochrome B gene partial sequence and RAPD analysis of two Daphnia longispina lineages differing in their resistance to copper. Martins, N., Lopes, I., Brehm, A., Ribeiro, R. Bulletin of environmental contamination and toxicology. (2005) [Pubmed]
  29. Evaluation of a microplate assay specific for heavy metal toxicity. Bitton, G., Jung, K., Koopman, B. Arch. Environ. Contam. Toxicol. (1994) [Pubmed]
  30. Evaluation of DGT as a metal speciation tool in wastewater. Buzier, R., Tusseau-Vuillemin, M.H., Mouchel, J.M. Sci. Total Environ. (2006) [Pubmed]
  31. Evaluation of a 14-day static renewal toxicity test with Daphnia magna straus. Gersich, F.M., Milazzo, D.P. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]
  32. Effects of plant species, age and part on the disappearance of sevin, nuvacron and malathion residues. Rawash, I.A., Gaaboub, I.A., El-Gayar, F.M., El-Shazli, A.Y. Toxicology (1975) [Pubmed]
  33. Ecotoxicological evaluation of 4-aminobiphenyl using a test battery. Chen, J., Yu, H., Liu, Y., Jiang, W., Jiang, J., Zhang, J., Hua, Z. Ecotoxicol. Environ. Saf. (2004) [Pubmed]
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