Disease relevance of Antigastrin

• We describe the first study of the antigastrin immunogen G17DT in pancreatic cancer [1].
• GR content of colon cancers may have prognostic significance and may identify a group of patients with colon cancer that may benefit from hormonal therapy with antigastrin drugs [2].
• Antigastrin agents may be a useful treatment for carcinoid either in their own right or as an adjunct to surgery [3].
• The therapeutic effectiveness of parenterally administered rabbit antigastrin antibody was evaluated in a patient with the Zollinger-Ellison syndrome who had a fasting serum gastrin level of 3020 pg/ml and a basal gastric acid secretion of 48.9 mEq/hr [4].

High impact information on Antigastrin

• However, when rats were pretreated with antigastrin serum or CCK-B receptor antagonist, the acid secretion by TE was virtually abolished [5].
• Immunocytochemical techniques using antigastrin antibody were employed to localize G cells in ectopic gastric mucosa of metaplastic and congenital origins and to compare their distribution with that in normal gastric mucosa [6].
• Serum gastrin was neutralized by antigastrin antibodies raised in situ by use of a gastrin immunogen, Gastrimmune [7].
• In addition, antigastrin antiserum added to HCT 116 cells adapted to growth in serum-free medium resulted in a concentration-dependent inhibition of cellular proliferation [8].
• Antigastrin/CCK antisera was also found to have dose-dependent cytostatic effects on HCT 116 and CBS cells adapted to growth in serum-free medium [9].

Anatomical context of Antigastrin

• Mucosal levels of gastrin in the antrum, fundus, and duodenum were greatly increased ten days after injection of antigastrin antibody [10].
• Using immunohistochemistry we localized a neurosecretory system, reacting with antigastrin sera, in the brain of amphibians by light and electron microscopy [11].
• The effects of SC-15396 is discussed with reference to the absence of receptors for gastrin related to gastric acid secretion in the codfish stomach [12].
• After ET-1 administration, the gastric mucosa of the pyloric gland area was immunostained with antigastrin [13].
• A morphometric method using specific antigastrin and antisomatostatin antibodies was used to estimate the density and the total number of antral gastrin and somatostatin cells [14].

Associations of Antigastrin with other chemical compounds

• Effect of atropine and SC-15396 on stimulated gastric acid secretion in the atlantic cod, Gadus morhua [12].
• After 14 days, the inhibition of gastric acid secretion, which induces an increase of gastrin release with other antisecretory drugs, remained counterbalanced by the antigastrin properties of enprostil [15].
• The effects of antigastrin (SC-15396) on amylase release and 2-deoxyglucose uptake were studied in dispersed acini from mouse pancreas [16].
• Proglumide and other antigastrin drugs inhibit gastrin binding in a dose-dependent way, and their activities in such a system are well correlated with the "in vivo" antisecretory activities of these drugs [17].
• These agents include the thymidylate synthase inhibitor capecitabine (which is possibly activated at the tumor site), the antigastrin immunogen G17DT (which is an immunization designed to neutralize the pancreatic growth factor gastrin), and the topoisomerase I inhibitor 9-nitrocamptothecin [18].

Gene context of Antigastrin

• Gastrin-producing cells were not identified in any tumors, despite the use of different antigastrin antisera [19].
• G cells of the frog antral mucosa are described both in deplasticized semithin sections treated with antigastrin/CCK COOH terminal serum and in subsequent thin sections observed under the electron microscope [20].
• SMS' antitrophic and antigastrin properties could be of great interest in long-term management of ZES [21].
• Hybrids of the double-chain bis-cystinyl fragment 225-232/225'-232' of human immunoglobulin G1 (IgG1) with the human little-gastrin sequence 2-17 were found to induce in animals a strong antigastrin humoral immune response with antibody titers comparable to those raised with conventional gastrin/carrier-protein conjugates [22].
• A PAP (peroxidase-antiperoxidase) system-associated antigastrin immunohistochemical method was used for cell identification [23].

Analytical, diagnostic and therapeutic context of Antigastrin

• This biological assay suggests that the antigastrin antibodies effectively bind gastrin-17 [24].

References