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Chemical Compound Review

Fendilin     3,3-diphenyl-N-(1- phenylethyl)propan-1-amine

Synonyms: Difmecor, Fendilina, fendiline, Fendilinum, Senzit, ...
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Disease relevance of fendiline


High impact information on fendiline


Chemical compound and disease context of fendiline


Biological context of fendiline


Anatomical context of fendiline


Associations of fendiline with other chemical compounds


Gene context of fendiline

  • Fendiline is more active against the oxytocin-induced contraction, probably due to an additional action on the fast Na+ channels [19].
  • Intracellular localization of the calcium- and calmodulin antagonist fendiline [20].
  • In this review, we present a new class of phenylalkylamines, based on the lead compound fendiline, that are potent positive potentiators of GABAB receptor-mediated function and discuss their putative clinical applications [21].

Analytical, diagnostic and therapeutic context of fendiline

  • The effects of fendiline on L-type Ca++ currents [ICa(L)] were investigated in rat ventricular cardiomyocytes using the patch-clamp technique both in the whole-cell disrupted-patch and in the cell-attached configuration [7].
  • Determination of fendiline in human plasma by means of capillary gas chromatography and nitrogen-phosphorus selective detection [22].
  • Capillary isotachophoresis was applied for the determination of fendiline and gallopamil--calcium antagonists--in serum [23].
  • By adding calcium to the medium, almost all types of muscle activation are established, after the inhibitory action of fendiline, except its depressive action on the electrical stimulation of the isolated rat uterus [19].
  • Fendiline was administered intravenously (3 mg) and orally (50 mg and 75 mg) in a cross-over study to six healthy volunteers [24].


  1. Comparison of two calcium antagonists, verapamil and fendiline, in an experimental model of myocardial ischaemia mimicking classical angina on effort. Csik, V., Szekeres, L., Udvary, E. Br. J. Pharmacol. (1983) [Pubmed]
  2. Fendiline, an anti-anginal drug, increases intracellular Ca2+ in PC3 human prostate cancer cells. Jan, C.R., Lee, K.C., Chou, K.J., Cheng, J.S., Wang, J.L., Lo, Y.K., Chang, H.T., Tang, K.Y., Yu, C.C., Huang, J.K. Cancer Chemother. Pharmacol. (2001) [Pubmed]
  3. Effects of the antianginal drug fendiline on Ca2+ movement in hepatoma cells. Cheng, J.S., Wang, J.L., Lo, Y.K., Chou, K.J., Lee, K.C., Liu, C.P., Chang, H.T., Jan, C.R. Human & experimental toxicology. (2001) [Pubmed]
  4. Double-blind, randomized study of the anti-anginal and anti-ischaemic efficacy of fendiline and diltiazem in patients with coronary heart disease. Schulz, J., Lubnau, E., Grossmann, M., Rück, W. Current medical research and opinion. (1991) [Pubmed]
  5. Basic mechanisms underlying prenylamine-induced 'torsade de pointes': differences between prenylamine and fendiline due to basic actions of the isomers. Bayer, R., Schwarzmaier, J., Pernice, R. Current medical research and opinion. (1988) [Pubmed]
  6. Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin. Förstermann, U., Gorsky, L.D., Pollock, J.S., Ishii, K., Schmidt, H.H., Heller, M., Murad, F. Mol. Pharmacol. (1990) [Pubmed]
  7. Open state block by fendiline of L-type Ca++ channels in ventricular myocytes from rat heart. Nawrath, H., Klein, G., Rupp, J., Wegener, J.W., Shainberg, A. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  8. Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Tripathi, O., Schreibmayer, W., Tritthart, H.A. Br. J. Pharmacol. (1993) [Pubmed]
  9. Effect of Sensit (fendiline) in angina pectoris. Böszörményi, E., Ludvigh, K., Fehér, G., Schwarz, J., Kármán, M., Sziebert, P. Therapia Hungarica (English edition) (1981) [Pubmed]
  10. Kinetic modulation of guinea-pig cardiac L-type calcium channels by fendiline and reversal of the effects of Bay K 8644. Schreibmayer, W., Tripathi, O., Tritthart, H.A. Br. J. Pharmacol. (1992) [Pubmed]
  11. Dual effect of the antianginal drug fendiline on bladder female transitional carcinoma cells: mobilization of intracellular CA2+ and induction of cell death. Jan, C.R., Yu, C.C., Huang, J.K. Pharmacology (2001) [Pubmed]
  12. Frequency- and time-dependent effects of fendiline on action potentials of guinea pig papillary muscle. Gautam, M., Tewari, A., Singh, S., Dixit, C., Raghu, K.G., Prakash, P., Tripathi, O. Jpn. J. Pharmacol. (2000) [Pubmed]
  13. Calmodulin antagonists inhibit endothelium-dependent hyperpolarization in the canine coronary artery. Nagao, T., Illiano, S., Vanhoutte, P.M. Br. J. Pharmacol. (1992) [Pubmed]
  14. Fendiline and calmidazolium enhance the release of endothelium-derived relaxant factor and of prostacyclin from cultured endothelial cells. Busse, R., Lückhoff, A., Winter, I., Mülsch, A., Pohl, U. Naunyn Schmiedebergs Arch. Pharmacol. (1988) [Pubmed]
  15. Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists. John, G.W., Fabrègues, E., Kamal, M., Massingham, R. Eur. J. Pharmacol. (1991) [Pubmed]
  16. The anti-anginal drug fendiline elevates cytosolic Ca(2+) in rabbit corneal epithelial cells. Lin, M.C., Jan, C.R. Life Sci. (2002) [Pubmed]
  17. 2'-Hydroxy-fendiline analogues as potent relaxers of isolated arteries. Wilkinson, J., Foretia, D., Rossington, S., Heagerty, A., Leonard, J., Hussain, N., Austin, C. Eur. J. Pharmacol. (2007) [Pubmed]
  18. Enhancement of the cytogenetic efficacy of the antitumor agent bleomycin by the calcium and calmodulin antagonist fendiline. Scheid, W., Traut, H. Experientia (1988) [Pubmed]
  19. The effect of fendiline on cAMP metabolism and activity of the isolated uterus of the rat. Milovanović, S.R., Varagić, V.M. Archives internationales de pharmacodynamie et de thérapie. (1987) [Pubmed]
  20. Intracellular localization of the calcium- and calmodulin antagonist fendiline. Weyhenmeyer, R., Gross, M., Maurer-Schultze, B. Arzneimittel-Forschung. (1989) [Pubmed]
  21. Clinical potential of GABAB receptor modulators. Ong, J., Kerr, D.I. CNS drug reviews. (2005) [Pubmed]
  22. Determination of fendiline in human plasma by means of capillary gas chromatography and nitrogen-phosphorus selective detection. Lohmann, A., Diekmann, N. J. Chromatogr. (1991) [Pubmed]
  23. Determination of fendiline and gallopamil by capillary isotachophoresis. Buzinkaiová, T., Polonský, J., Skacáni, I. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
  24. Single dose pharmacokinetics of fendiline in humans. Kukovetz, W.R., Brunner, F., Beubler, E., Weyhenmeyer, R., Lohaus, R., Grob, M., Mayer, D. European journal of drug metabolism and pharmacokinetics. (1982) [Pubmed]
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