Disease relevance of iofetamine

• Increased iofetamine I 123 brain uptake in metastatic melanoma [1].
• These findings suggest that certain brain tumors such as melanoma are capable of selectively binding iofetamine I 123 because of specific chemical properties of the radiopharmaceutical [1].
• Iodine-123-IMP may have a potential role in evaluating carcinoid tumors [2].
• Early and delayed SPECT using N-isopropyl p-iodoamphetamine iodine 123 in cerebral ischemia. A prognostic index for clinical recovery [3].
• Sixteen patients with stroke, five patients with permanent regressive ischemic neurologic deficit, and three patients with transient ischemic attacks were studied by single photon emission computed tomography performed within the first hour (early scan) and four hours (delayed scan) after injection of N-isopropyl-p-iodoamphetamine-iodine-123 (IMP) [3].

Psychiatry related information on iofetamine

• Iofetamine I 123 single photon emission computed tomography is accurate in the diagnosis of Alzheimer's disease [4].
• I-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: a clinical study [5].
• Single photon emission computed tomography in Alzheimer's disease. Abnormal iofetamine I 123 uptake reflects dementia severity [6].
• Although seizures did not occur at 9 years of age, she manifested dyscalculia, right-left disorientation, and finger agnosia, and N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (SPECT) revealed focal hypoperfusion in the left parietal lobe [7].

High impact information on iofetamine

• Acetazolamide challenge and technetium-99m-ECD versus iodine-123-IMP SPECT in chronic occlusive cerebrovascular disease [8].
• Iodine-123-labeled N-isopropyl-p-iodoamphetamine (IMP) has been reported to be an excellent tracer for mapping cerebral blood flow with single-photon emission computed tomography (SPECT) [9].
• Lung endothelial N-isopropyl-p-iodoamphetamine (IMP) binding sites were assessed applying principles of competitive binding assay adapted for in vivo measurements obtained by digital imaging [10].
• The physicochemical parameters, partition coefficient vs. pH profile, and protein binding, as well as biodistribution in rats, were very similar to those of I-123 IMP (N-isopropyl-p-iodoamphetamine) [11].
• The left middle cerebral artery of four rats was occluded, and the animals were simultaneously injected with 25 microCi of iodine-125 iomazenil and 500 microCi of the blood flow tracer [123I]iofetamine (N-isopropyl-p-iodoamphetamine) [12].

Anatomical context of iofetamine

• Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine [13].
• Metabolism in vitro of radioiodinated N-isopropyl-p-iodoamphetamine by isolated hepatocytes [14].
• Temporal lobe asymmetry with iofetamine (IMP) SPECT imaging in patients with major depression [15].
• N-isopropyl p-iodoamphetamine (I-123 IMP) was used in two patients with previous unilateral basal ganglia infarcts documented by CT of the head [16].
• Caudate nucleus infarction demonstrated by N-isopropyl-p iodoamphetamine SPECT imaging using a rotating gamma camera [16].

Gene context of iofetamine

• I-123 iofetamine SPECT scan in systemic lupus erythematosus patients with cognitive and other minor neuropsychiatric symptoms: a pilot study [17].

Analytical, diagnostic and therapeutic context of iofetamine

• It is based on two successive intravascular injections of N-isopropyl-p-iodoamphetamine (IMP) labelled with different radionuclides, whose concentrations can later be differentiated in the same tissue section using double-radionuclide autoradiography [18].
• To assess brain functional activity in patients with PSP, we measured regional cerebral perfusion, as estimated by [123I] iofetamine (IMP) and single-photon emission computed tomography (SPECT), in 11 patients with a clinical diagnosis of PSP and 10 healthy control subjects [19].
• N-isopropyl p-iodoamphetamine (IMP) demonstrates a high affinity for lung and brain during the first pass following intravenous injection [20].
• Effects of visual stimulation on the redistribution of iodine-123-IMP in the brain using SPECT imaging [21].
• Increased uptake of iofetamine I 123 in brain lesions in a patient at risk for metastatic melanoma may be a useful aid to differential diagnosis [1].

References