Disease relevance of Parietal Lobe

• Fourteen patients had unilateral frontal lobe epilepsy, five occipital lobe epilepsy (OLE), six parietal lobe epilepsy (PLE) and 19 neocortical epilepsy that was not clearly lobar [1].
• Wave P 300 was studied in nine patients with parietal lobe lesions who had visual neglect but no hemianopia [2].
• We present an unusual case of a patient who was diagnosed with temporal lobe epilepsy and whose seizures were reduced markedly after excision of an angiographically occult arteriovenous malformation (AVM) located in the left medial parietal lobe [3].
• The interrelationship between CAOs and amyloid deposits was examined by immunohistochemistry in the parietal lobe of patients with Parkinson's disease, diffuse Lewy body disease, and pallido-nigro-luysial atrophy [4].
• Of the 31 patients with causative lesions on MRI there were 24 vestibular schwannomas, 2 glomus jugulare tumors, 2 ectatic basilar arteries with brainstem compression, 1 petrous apex cholesterol granuloma, 1 case of possible demyelinating disease, and 1 parietal lobe mass [5].

Psychiatry related information on Parietal Lobe

• Reaction time costs plus benefits were correlated with right-left asymmetry in resting levels of cerebral glucose metabolism in the superior parietal lobe for DAT patients but not for controls [6].
• These results are rather unexpected but are consistent with other data (e.g. the clinical parietal lobe syndrome and focus of glucose hypometabolism in Alzheimer's disease) [7].
• Degree of impairment was related to Glascow Coma Scale score, length of posttraumatic amnesia, reduced visuospatial and memory abilities, and the presence of intracranial pathology of the parietal lobes [8].

High impact information on Parietal Lobe

• RESULTS: Deficit patients performed more poorly than nondeficit patients on two frontal lobe measures, the Stroop Color-Word Interference and Trails Making B tests, and one parietal lobe measure, the Mooney Faces Closure Test. There were no differences in performance on the temporal lobe measures between the two groups [9].
• Parietal lobe epilepsy: diagnostic considerations and results of surgery [10].
• Biopsy-proved Alzheimer disease presenting as a right parietal lobe syndrome [11].
• More transparent Spanish words yielded greater activity in superior temporal gyrus (STG; BA 22), a region implicated in phonological processing, and orthographically opaque English words yielded greater activity in visual processing and word recoding regions, such as the occipito-parietal border and inferior parietal lobe (IPL; BA 40) [12].
• Although mild perfusion defect was also detected in 4 (19.0%) of the patients with non-CNS-SLE, it only involved a single region and spared the frontal and parietal lobes [13].

Chemical compound and disease context of Parietal Lobe

• Magnetic resonance imaging (MRI) and (1)H MR spectroscopic findings showed a mass and surrounding vasogenic edema in the deep left parietal lobe suggestive of malignant angiosarcoma [14].

Biological context of Parietal Lobe

• Median nerve short-latency somatosensory evoked potentials (MN-SSEP) are recorded from the scalp to assess parietal lobe function and from the cortex to identify primary sensory and motor areas before epilepsy surgery [15].

Anatomical context of Parietal Lobe

• In response to FEN, relative regional uptake of FDG (relative to placebo) was greater in control participants compared to patients in medial and orbital regions of right prefrontal cortex (BA 10), left middle and superior temporal gyri (BA 22-23), left parietal lobe (BA 40), and left caudate body [16].
• OBJECTIVE: To determine via magnetic resonance imaging if the posterior corpus callosum is reduced in the midline cross-sectional area in autistic patients, consistent with previous reports of parietal lobe abnormalities [17].
• The effects of noxious and innocuous mechanical stimulation of various segmental skin areas (face, forelimb and paw, back, hindlimb and paw) on extracellular acetylcholine release in the cerebral cortex in the parietal lobe were examined in halothane-anesthetized rats, by means of the microdialysis technique [18].
• Moderately higher GLUT3 mRNA levels were detected in the parietal lobe of the cerebrum, hippocampus, and cerebellum than the levels of GLUT1 transcripts [19].
• However, statistical parametric mapping of differences in CMRglu between placebo and fluoxetine conditions revealed regional effects of fluoxetine shown by decreased metabolism in the amygdaloid complex, hippocampal formation and ventral striatum, and by increased metabolism centered in the right superior parietal lobe (Brodmann area 7) [20].

Associations of Parietal Lobe with chemical compounds

• Lesions involved the superior temporal gyrus (including the planum temporale), the inferior parietal lobe and the parietal operculum; this area appears to constitute the human auditory cortical processing area [21].
• In all subjects, verbal competency generally correlated with metabolic activity in the left frontal and temporal areas, while visuo-constructive test performance was linked to glucose utilization in the right parietal lobe [22].
• Women with TS had a significantly lower parietal lobe concentration of N-acetyl aspartate, and higher hippocampal choline [23].
• MRS of the frontal and parietal lobes showed no differences in the N-acetyl aspartate/creatine or N-acetyl aspartate/choline ratios between groups A and B. Patients with cortical atrophy showed a nonsignificant trend toward reduced performance on Rapid Visual Information Processing [24].
• Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD [25].

Gene context of Parietal Lobe

• Positron emission tomography studies in patients with Alzheimer disease have revealed a typical pattern of metabolic deficits in the temporal and parietal lobes [26].
• The between-group whole-brain comparison showed greater magnitude of activation for control subjects than children with ADHD in the right superior parietal lobe during both right-handed and left-handed finger tapping [27].
• They were followed within 70 msec by signals originating in the posterior parietal lobe close to midline (precuneus) and, 100 msec later, in the posterior superior temporal areas, predominantly in the left hemisphere [28].
• Normal symmetry of parietal lobe tissue observed in the comparison group was not evident in the velocardiofacial syndrome group [29].
• In the hippocampus, frontal lobe, and parietal lobe, the CRE-BP1 mRNA was abundant and two mRNA species 4.0 kb and 3.7 kb in length were expressed [30].

Analytical, diagnostic and therapeutic context of Parietal Lobe

• RESULTS: 99mTc ECD brain SPECT showed brain regions with hypoperfusion in 18 (56.3%) of the 32 patients, and parietal lobes were the most common areas with such lesions [31].
• Glucose metabolic images obtained by [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography showed diffusely reduced whole brain metabolism and strongly decreased metabolism in the frontal and parietal lobes, orbital gyrus, and thalamus [32].
• Responses of extracellular acetylcholine (ACh) release and blood flow in the cerebral cortex in the parietal lobe following focal electrical stimulation of the nucleus basalis of Meynert (NBM) ipsilateral to the parietal cortex were compared in healthy adult (6-8 months) and aged (27-28 months) Fischer-344 rats anesthetized with halothane [33].
• We present a case of parietal lobe epilepsy, the epileptogenic focus of which was conspicuously demonstrated on magnetoencephalography (MEG) [34].
• The patient was successfully treated with administration of a combination of antifungal agents (including intraventricular amphotericin B), drainage of the parietal lobe abscess, and cessation of immunosuppression [35].

References