Disease relevance of Tetracarbonylnickel

• Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia [1].
• Chromosomal aberration and sister-chromatid exchange (SCE) base-line frequencies and SCE frequencies induced by 10 ng/ml mitomycin C (MMC) were analysed in cultured peripheral lymphocytes of 65 workers occupationally exposed to nickel carbonyl Ni(CO)4 [2].
• Almost all cases of acute nickel toxicity result from exposure to nickel carbonyl [3].
• The experiments presented here indicate that the diethyldithiocarbamate is able to reach and bind the intracellular Ni2+ in the critical target tissues and this property may underlie the ability of the compound to act as an antidote in nickel carbonyl intoxications [4].
• Exposure of rats to inhalation of Ni(CO)4 (1.2 to 6.4 mumole per liter of air per 15 min) caused acute hyperglycemia, similar to that observed after ip injection of NiCl2 [5].

High impact information on Tetracarbonylnickel

• Experimental X-ray charge density studies on the binary carbonyls Cr(CO)6, Fe(CO)5, and Ni(CO)4 [6].
• The inhaled nickel carbonyl is rapidly absorbed and distributed mainly to the lungs, brain, adrenal glands, and kidneys [7].
• Cytogenetic analysis in workers occupationally exposed to nickel carbonyl [2].
• Nickel concentrations in body fluids should not, at present, be viewed as indicators of specific health risks, except in persons exposed to nickel carbonyl, for whom urine nickel concentrations provide prognostic guidance on the severity of the poisoning [8].
• Owing to their low absorption from the gastrointestinal tract, nickel compounds, except nickel carbonyl, are essentially non-toxic after ingestion [9].

Chemical compound and disease context of Tetracarbonylnickel

• Respiratory failure from inhalational nickel carbonyl exposure treated with continuous high-volume hemofiltration and disulfiram [10].

Biological context of Tetracarbonylnickel

• Urinary excretions of protein and amino acids were measured before and after exposure of rats to inhalation of nickel carbonyl in LD40 dosage [11].
• A 46-year-old man presented to the emergency department 24 hours after accidental occupational exposure to nickel carbonyl [12].
• The specificity of the treatment is demonstrated in an industrial accident in which four men were simultaneously exposed to nickel carbonyl vapors [13].
• Hyperglycemia induced by NiCl2 and Ni(CO)4 was not associated with inhibition of erythrocyte glycolysis measured in vitro by erythrocyte uptake of 1-14C-glucose and release of 14CO2 [5].
• With the exception of nickel carbonyl poisoning, no health risk estimation can be performed based on the results of biological monitoring [14].

Anatomical context of Tetracarbonylnickel

• The proportions of litters with malformed fetuses were 33% (4/12) and 24% (4/17) in dams exposed to Ni(CO)4 on days 4 and 5 of gestation (P less than 0.05, versus 0/9 in litters of control dams) [15].

Analytical, diagnostic and therapeutic context of Tetracarbonylnickel

• Further studies should be performed to clarify the role of chelation therapy in the subacute phases following nickel carbonyl exposure [7].
• Study on lung function and blood gas analysis of nickel carbonyl workers [16].
• Determination of Ni(CO)4, Fe(CO)5, Mo(CO)6, and W(CO)6 in sewage gas by using cryotrapping gas chromatography inductively coupled plasma mass spectrometry [17].
• A study of serum monoamine oxidase (MAO) activity and the EEG in nickel carbonyl workers [18].
• The distribution of 63Ni- and 14C-labelled nickel carbonyl was studied in mice by whole-body autoradiography and by liquid scintillation counting [19].

References