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Chemical Compound Review:

CHEMBL482477 (Z)-7-[(1S,5E)-5-[(E)-oct-2- enylidene]-4...

Synonyms: BSPBio_001361, HMDB05079, CHEBI:607727, AC1NSK7W, BML2-B05, ...

Jeon, M.J. et al., Heinlein, C.A. et al., Vanaja, D.K. et al., Kobayashi, Y. et al., Forman, B.M. et al., et al.

Badawi, Badr, Ianaro, Ialenti, Maffia, Di Meglio, Di Rosa, Santoro, Yagami, Ueda, Asakura, Takasu, Sakaeda, Itoh, Sakaguchi, Kishino, Nakazato, Katsuyama, Nagasaki, Okamura, Hori, Hanasaki, Arimura, Fujimoto, Masamune, Kikuta, Satoh, Sakai, Satoh, Shimosegawa,

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Disease relevance of AIDS039990

Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells [1].
Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells [2].
15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) is a bioactive prostanoid produced by dehydration and isomerization of PGD2, a cyclooxygenase product [3].
We further examined the effects of PPARgamma agonist 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), a naturally occurring PPARgamma ligand, to these endometrial carcinoma cell lines [4].
15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells [5].

High impact information on AIDS039990

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma [6].
By assaying arachidonate metabolites for their capacity to activate PPAR response elements, we have identified 15-deoxy-delta 12, 14-prostaglandin J2 as both a PPAR gamma ligand and an inducer of adipogenesis [6].
15-deoxy-Delta12,14-PGJ2 (15d-PGJ2) has been identified as an endogenous ligand for PPARgamma, inducing adipogenesis in vitro [7].
In this study, 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2)-induced Hsp70 was purified from transgenic adenocarcinoma mouse prostate cells (TRAMP-C2) [1].
Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation [8].

Chemical compound and disease context of AIDS039990

Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis [9].
Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis [10].
We investigated whether treatment with pioglitazone (PGZ), rosiglitazone (RGZ) or 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) inhibited tumor cell growth in five human multiple myeloma cell lines (LP-1, U-266, RPMI-8226-S, OPM-2 and IM-9) and human bone marrow myeloma cells expressing PPAR-gamma protein [11].
1. Previously, we have demonstrated that 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) enhances acute lung injury induced by lipopolysaccharide (LPS) in mice [12].
METHODS: The effect of two PPARgamma ligands, 15 deoxy-delta12,14 prostaglandin J2 (15d-PGJ2) and ciglitazone, on the growth of four human pancreatic cancer cell lines (BxPC-3, MIA PaCa-2, Panc-1, and L3.6) was assessed [13].

Biological context of AIDS039990

15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts [14].
15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity [15].
Similarly, in transient transfection of DU145 cells, cotransfection of PPARgamma and ARA70 induces transcription from reporter constructs driven by either three copies of an isolated PPAR response element or the natural promoter of the adipocyte fatty acid-binding protein 2 in the absence of exogenous 15-deoxy-Delta12,14-prostaglandin J2 [16].
Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression [17].
Novel binding sites of 15-deoxy-Delta12,14-prostaglandin J2 in plasma membranes from primary rat cortical neurons [18].

Anatomical context of AIDS039990

The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma [19].
15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications [20].
15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process [21].
15-Deoxy-Delta12,14-PGJ2 (15d-PGJ2), mainly produced by mast cells, is known as a potent lipid mediator derived from PGD2 in vivo [8].
Treatment of MC3T3-E1 osteoblasts and ROS 17/2.8 cells stably transfected with PPARgamma2 with the PPARgamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibited the mRNA expression of osteocalcin and Runx2, the latter of which is a key transcription factor in osteoblast differentiation [22].

Associations of AIDS039990 with other chemical compounds

Activation of PPAR-gamma was induced with 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) or with troglitazone [23].
We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia [24].
Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response [25].
Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha [26].
15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway [27].

Gene context of AIDS039990

Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism [28].
PPARgamma and ARA70 interact in the absence of the PPARgamma ligand 15-deoxy-Delta12,14-prostaglandin J2, although the addition of exogenous ligand enhances this interaction [16].
However, in addition to this indirect effect, the activation of PPARgamma by 15-deoxy-Delta12,14-prostaglandin J2 directly suppressed the Runx2-mediated induction of the activities of the osteocalcin promoter and the artificial promoter p6OSE2, which contains six tandem copies of osteoblast-specific element-2, the Runx2-binding promoter sequence [22].
15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells [29].
We found that ECs did not express either PPAR-gamma1 or PPAR-gamma2 protein and were not sensitive to growth inhibition by the PPAR-gamma ligand 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) [30].

Analytical, diagnostic and therapeutic context of AIDS039990

Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma [7].
Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis [31].
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut [32].
15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors [33].
Treatment of THP-1 cells with 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) resulted in more than 20% induction in the expression of PPAR-gamma5 and PPAR-gamma7 transcripts by both Northern blot analysis and RT-PCR [34].

References

Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. Vanaja, D.K., Grossmann, M.E., Celis, E., Young, C.Y. Cancer Res. (2000) [Pubmed]
Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. Chinery, R., Coffey, R.J., Graves-Deal, R., Kirkland, S.C., Sanchez, S.C., Zackert, W.E., Oates, J.A., Morrow, J.D. Cancer Res. (1999) [Pubmed]
Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. Bishop-Bailey, D., Hla, T. J. Biol. Chem. (1999) [Pubmed]
Peroxisome proliferator-activated receptor gamma and growth inhibition by its ligands in uterine endometrial carcinoma. Ota, K., Ito, K., Suzuki, T., Saito, S., Tamura, M., Hayashi, S., Okamura, K., Sasano, H., Yaegashi, N. Clin. Cancer Res. (2006) [Pubmed]
15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. Clay, C.E., Monjazeb, A., Thorburn, J., Chilton, F.H., High, K.P. J. Lipid Res. (2002) [Pubmed]
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Forman, B.M., Tontonoz, P., Chen, J., Brun, R.P., Spiegelman, B.M., Evans, R.M. Cell (1995) [Pubmed]
Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. Bell-Parikh, L.C., Ide, T., Lawson, J.A., McNamara, P., Reilly, M., FitzGerald, G.A. J. Clin. Invest. (2003) [Pubmed]
Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. Kobayashi, Y., Ueki, S., Mahemuti, G., Chiba, T., Oyamada, H., Saito, N., Kanda, A., Kayaba, H., Chihara, J. J. Immunol. (2005) [Pubmed]
Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. Badawi, A.F., Badr, M.Z. Int. J. Cancer (2003) [Pubmed]
Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. Storer, P.D., Xu, J., Chavis, J.A., Drew, P.D. J. Neurosci. Res. (2005) [Pubmed]
Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. Eucker, J., Bängeroth, K., Zavrski, I., Krebbel, H., Zang, C., Heider, U., Jakob, C., Elstner, E., Possinger, K., Sezer, O. Anticancer Drugs (2004) [Pubmed]
Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. Inoue, K., Takano, H., Yanagisawa, R., Ichinose, T., Sadakane, K., Yoshino, S., Yamaki, K., Uchiyama, K., Yoshikawa, T. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells. Hashimoto, K., Ethridge, R.T., Evers, B.M. International journal of gastrointestinal cancer. (2002) [Pubmed]
15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. Relic, B., Benoit, V., Franchimont, N., Ribbens, C., Kaiser, M.J., Gillet, P., Merville, M.P., Bours, V., Malaise, M.G. J. Biol. Chem. (2004) [Pubmed]
15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. Ruiz, P.A., Kim, S.C., Sartor, R.B., Haller, D. J. Biol. Chem. (2004) [Pubmed]
Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. Heinlein, C.A., Ting, H.J., Yeh, S., Chang, C. J. Biol. Chem. (1999) [Pubmed]
Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression. Kwon, G., Xu, G., Marshall, C.A., McDaniel, M.L. J. Biol. Chem. (1999) [Pubmed]
Novel binding sites of 15-deoxy-Delta12,14-prostaglandin J2 in plasma membranes from primary rat cortical neurons. Yagami, T., Ueda, K., Asakura, K., Takasu, N., Sakaeda, T., Itoh, N., Sakaguchi, G., Kishino, J., Nakazato, H., Katsuyama, Y., Nagasaki, T., Okamura, N., Hori, Y., Hanasaki, K., Arimura, A., Fujimoto, M. Exp. Cell Res. (2003) [Pubmed]
The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. Giri, S., Rattan, R., Singh, A.K., Singh, I. J. Immunol. (2004) [Pubmed]
15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. Si, Q., Zhao, M.L., Morgan, A.C., Brosnan, C.F., Lee, S.C. J. Immunol. (2004) [Pubmed]
15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. Cheron, A., Peltier, J., Perez, J., Bellocq, A., Fouqueray, B., Baud, L. J. Immunol. (2004) [Pubmed]
Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. Jeon, M.J., Kim, J.A., Kwon, S.H., Kim, S.W., Park, K.S., Park, S.W., Kim, S.Y., Shin, C.S. J. Biol. Chem. (2003) [Pubmed]
Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. Masamune, A., Kikuta, K., Satoh, M., Sakai, Y., Satoh, A., Shimosegawa, T. J. Biol. Chem. (2002) [Pubmed]
15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. Park, E.J., Park, S.Y., Joe, E.H., Jou, I. J. Biol. Chem. (2003) [Pubmed]
Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. Ianaro, A., Ialenti, A., Maffia, P., Di Meglio, P., Di Rosa, M., Santoro, M.G. Mol. Pharmacol. (2003) [Pubmed]
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Thomas, R.K., Sos, M.L., Zander, T., Mani, O., Popov, A., Berenbrinker, D., Smola-Hess, S., Schultze, J.L., Wolf, J. Clin. Cancer Res. (2005) [Pubmed]
15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. Phulwani, N.K., Feinstein, D.L., Gavrilyuk, V., Akar, C., Kielian, T. J. Neurochem. (2006) [Pubmed]
Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. Farrajota, K., Cheng, S., Martel-Pelletier, J., Afif, H., Pelletier, J.P., Li, X., Ranger, P., Fahmi, H. Arthritis Rheum. (2005) [Pubmed]
15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. Rajasingh, J., Bright, J.J. Exp. Cell Res. (2006) [Pubmed]
Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. Subbarayan, V., Sabichi, A.L., Kim, J., Llansa, N., Logothetis, C.J., Lippman, S.M., Menter, D.G. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. Millán, O., Rico, D., Peinado, H., Zarich, N., Stamatakis, K., Pérez-Sala, D., Rojas, J.M., Cano, A., Boscá, L. Carcinogenesis (2006) [Pubmed]
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. Cuzzocrea, S., Pisano, B., Dugo, L., Ianaro, A., Patel, N.S., Di Paola, R., Genovese, T., Chatterjee, P.K., Di Rosa, M., Caputi, A.P., Thiemermann, C. Br. J. Pharmacol. (2003) [Pubmed]
15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. Fulzele, S.V., Chatterjee, A., Shaik, M.S., Jackson, T., Ichite, N., Singh, M. Anticancer Drugs (2007) [Pubmed]
Identification and regulation of novel PPAR-gamma splice variants in human THP-1 macrophages. Chen, Y., Jimenez, A.R., Medh, J.D. Biochim. Biophys. Acta (2006) [Pubmed]

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