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Chemical Compound Review

Doproston     7-[(1R,2S)-2-[(E,3S)-3- hydroxyoct-1-enyl]...

Synonyms: Doprostone, SureCN1056605, STOCK1N-55754, AY-23578, LMFA03010054, ...
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High impact information on Doproston

  • MATERIALS AND METHODS: A bone marrow culture system and bone marrow macrophages were used to examine the effects of SC-19220 on PGE2-, 11-deoxy-PGE1-, and RANKL-induced osteoclastogenesis [1].
  • Alkaline phosphatase-positive nodule formation in the absence or presence of XT-611 was inhibited by an antagonist of EP4 receptor, AH23848B, and synergistically potentiated by 11-deoxy-PGE1, but it was not influenced by other EP antagonists and agonists examined [2].
  • RESULTS: PGE2 and cyclic AMP inhibited spontaneous eosinophil apoptosis at both 16 and 40 hours as did the PGEP2 receptor agonist, 11-deoxy PGE1, at 40 hours, but these effects were not inhibited by a protein kinase A antagonist [3].
  • In contrast, 11-deoxy-PGE1 failed to inhibit the ERK activity in SHRSP-MCs [4].
  • Butaprost, an EP2-selective agonist, showed effects similar to those of 11-deoxy-PGE1 only at confluency [5].

Biological context of Doproston


Anatomical context of Doproston


Associations of Doproston with other chemical compounds


Gene context of Doproston


  1. SC-19220, antagonist of prostaglandin E2 receptor EP1, inhibits osteoclastogenesis by RANKL. Tsujisawa, T., Inoue, H., Nishihara, T. J. Bone Miner. Res. (2005) [Pubmed]
  2. Prostaglandin E2-mediated anabolic effect of a novel inhibitor of phosphodiesterase 4, XT-611, in the in vitro bone marrow culture. Miyamoto, K., Suzuki, H., Yamamoto, S., Saitoh, Y., Ochiai, E., Moritani, S., Yokogawa, K., Waki, Y., Kasugai, S., Sawanishi, H., Yamagami, H. J. Bone Miner. Res. (2003) [Pubmed]
  3. PGE 2 and dibutyryl cyclic adenosine monophosphate prolong eosinophil survival in vitro. Peacock, C.D., Misso, N.L., Watkins, D.N., Thompson, P.J. J. Allergy Clin. Immunol. (1999) [Pubmed]
  4. Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats. Suganami, T., Tanaka, I., Mukoyama, M., Kotani, M., Muro, S., Mori, K., Goto, M., Ishibashi, R., Kasahara, M., Yahata, K., Makino, H., Sugawara, A., Nakao, K. J. Hypertens. (2001) [Pubmed]
  5. Prostaglandin E receptor subtypes in mouse osteoblastic cell line. Suda, M., Tanaka, K., Natsui, K., Usui, T., Tanaka, I., Fukushima, M., Shigeno, C., Konishi, J., Narumiya, S., Ichikawa, A., Nakao, N. Endocrinology (1996) [Pubmed]
  6. Prostaglandin E2 binding site distribution and subtype classification in the rabbit iris-ciliary body. Csukas, S., Bhattacherjee, P., Rhodes, L., Paterson, C.A. Prostaglandins (1992) [Pubmed]
  7. Membrane currents elicited by prostaglandins, atrial natriuretic factor and oxytocin in follicle-enclosed Xenopus oocytes. Miledi, R., Woodward, R.M. J. Physiol. (Lond.) (1989) [Pubmed]
  8. Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells. Lindsey, J.D., Kashiwagi, K., Boyle, D., Kashiwagi, F., Firestein, G.S., Weinreb, R.N. Curr. Eye Res. (1996) [Pubmed]
  9. Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes. Konger, R.L., Malaviya, R., Pentland, A.P. Biochim. Biophys. Acta (1998) [Pubmed]
  10. Mechanisms involved in prostaglandin-induced increase in bone resorption in neonatal mouse calvaria. Gardner, C.R., Blanqué, R., Cottereaux, C. Prostaglandins Leukot. Essent. Fatty Acids (2001) [Pubmed]
  11. Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. Choung, J., Taylor, L., Thomas, K., Zhou, X., Kagan, H., Yang, X., Polgar, P. J. Cell. Biochem. (1998) [Pubmed]
  12. Prostaglandin E2 downregulates interferon-gamma-induced intercellular adhesion molecule-1 expression via EP2 receptors in human gingival fibroblasts. Noguchi, K., Iwasaki, K., Shitashige, M., Murato, S., Ishikawa, I. Inflammation (1999) [Pubmed]
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