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Chemical Compound Review

fluprostenol     (Z)-7-[(1R,2S,3R,5S)-3,5- dihydroxy-2-[(E...

Synonyms: Fluprostenolum, AC1NSJZQ, SureCN230607, BSPBio_001336, CHEBI:60782, ...
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Disease relevance of fluprostenol

  • Fluprostenol-induced activation was pertussis toxin resistant [1].
  • Cicaprost and fluprostenol were virtually inactive; they also failed to modify copper sulphate (100 mg/kg, intragastric)-induced emesis (P>0.05), although cicaprost potentiated apomorphine (0.25 mg/kg, s.c.)-induced emesis (P<0.05) [2].
  • A total of 941 mares have been treated with fluprostenol in an international trial, for various forms of infertility associated with abnormal persistence of luteal function [3].
  • In addition, administration of fluprostenol, a more selective agonist at the PGF(2alpha) receptor, induced cardiac hypertrophy in rats [4].
  • Time between birth and first suckling, body weight, rectal temperature, pulse rate, and respiratory rate at birth and serum IgG concentration 24 hours after birth were not different between crias born after fluprostenol treatment and crias born to control alpacas [5].

High impact information on fluprostenol


Biological context of fluprostenol


Anatomical context of fluprostenol


Associations of fluprostenol with other chemical compounds


Gene context of fluprostenol


Analytical, diagnostic and therapeutic context of fluprostenol


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  2. Actions of prostanoids to induce emesis and defecation in the ferret. Kan, K.K., Jones, R.L., Ngan, M.P., Rudd, J.A. Eur. J. Pharmacol. (2002) [Pubmed]
  3. Fluprostenol in mares: clinical trials for the treatment of infertility. Cooper, M.J. Vet. Rec. (1976) [Pubmed]
  4. Inhibitory effects of interferon-gamma on myocardial hypertrophy. Jin, H., Li, W., Yang, R., Ogasawara, A., Lu, H., Paoni, N.F. Cytokine (2005) [Pubmed]
  5. Induction of parturition in alpacas and subsequent survival of neonates. Bravo, P.W., Bazan, P.J., Troedsson, M.H., Villalta, P.R., Garnica, J.P. J. Am. Vet. Med. Assoc. (1996) [Pubmed]
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  9. Responses of intraocular pressure and the pupil of feline eyes to prostaglandin EP1 and FP receptor agonists. Bhattacherjee, P., Williams, B.S., Paterson, C.A. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  10. Fluprostenol-induced softening of the cervix of the pregnant rat. Williams, L.M., Hollingsworth, M., Dukes, M., Morris, I.D. J. Endocrinol. (1983) [Pubmed]
  11. In-vivo myometrial electrical activity in the cyclic mare. Taverne, M.A., van der Weyden, G.C., Fontijne, P., Dieleman, S.J., Pashen, R.L., Allen, W.R. J. Reprod. Fertil. (1979) [Pubmed]
  12. Studies on equine prematurity 1: Methodology. Rossdale, P.D., Ousey, J.C., Dudan, F.E., Leadon, D.P., Cash, R.S., Reddy, R., Silver, M., Fowden, A., Broughton Pipkin, F., Jeffcott, L.B. Equine Vet. J. (1984) [Pubmed]
  13. Prostaglandins regulate the expression of fibroblast growth factor-2 in bone. Sabbieti, M.G., Marchetti, L., Abreu, C., Montero, A., Hand, A.R., Raisz, L.G., Hurley, M.M. Endocrinology (1999) [Pubmed]
  14. The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha. Miller, C.W., Casimir, D.A., Ntambi, J.M. Endocrinology (1996) [Pubmed]
  15. Identification of a prostanoid FP receptor population producing endothelium-dependent vasorelaxation in the rabbit jugular vein. Chen, J., Champa-Rodriguez, M.L., Woodward, D.F. Br. J. Pharmacol. (1995) [Pubmed]
  16. Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. Woodward, D.F., Krauss, A.H., Chen, J., Gil, D.W., Kedzie, K.M., Protzman, C.E., Shi, L., Chen, R., Krauss, H.A., Bogardus, A., Dinh, H.T., Wheeler, L.A., Andrews, S.W., Burk, R.M., Gac, T., Roof, M.B., Garst, M.E., Kaplan, L.J., Sachs, G., Pierce, K.L., Regan, J.W., Ross, R.A., Chan, M.F. Br. J. Pharmacol. (2000) [Pubmed]
  17. Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data. Sharif, N.A., Xu, S.X., Williams, G.W., Crider, J.Y., Griffin, B.W., Davis, T.L. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  18. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. Lake, S., Gullberg, H., Wahlqvist, J., Sjögren, A.M., Kinhult, A., Lind, P., Hellström-Lindahl, E., Stjernschantz, J. FEBS Lett. (1994) [Pubmed]
  19. The use of synthetic prostaglandin analogue to induce oestrus in mares. Shepherd, G.E., Findlay, J.K., Cooper, M.J., Allen, W.R. Aust. Vet. J. (1976) [Pubmed]
  20. Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Tsingotjidou, A., Nervina, J.M., Pham, L., Bezouglaia, O., Tetradis, S. Bone (2002) [Pubmed]
  21. Modulation of JB6 mouse epidermal cell transformation response by the prostaglandin F2alpha receptor. Weber, T.J., Markillie, L.M., Chrisler, W.B., Vielhauer, G.A., Regan, J.W. Mol. Carcinog. (2002) [Pubmed]
  22. Characterization of excitatory prostanoid receptors in the human umbilical artery in vitro. Boersma, J.I., Janzen, K.M., Oliveira, L., Crankshaw, D.J. Br. J. Pharmacol. (1999) [Pubmed]
  23. Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase. Sabbieti, M.G., Marchetti, L., Gabrielli, M.G., Menghi, M., Materazzi, S., Menghi, G., Raisz, L.G., Hurley, M.M. Cell Tissue Res. (2005) [Pubmed]
  24. Prostaglandin F2 alpha upregulates intercellular adhesion molecule-1 expression in human gingival fibroblasts. Noguchi, K., Iwasaki, K., Ishikawa, I. J. Periodont. Res. (1999) [Pubmed]
  25. Use of short high-performance liquid chromatography columns and tandem-mass spectrometry for the rapid analysis of a prostaglandin analog, fluprostenol, in rat plasma. Eichhold, T.H., Kuhlenbeck, D.L., Baker, T.R., Stella, M.E., Amburgey, J.S., deLong, M.A., Hartke, J.R., Cruze, C.A., Pierce, S.A., Wehmeyer, K.R. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
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