The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NSJSW     (Z)-7-[(1R,2R,5S)-2- morpholin-4-yl-3-oxo-5...

Synonyms: SureCN3488581, AH-23848, AH-23848B, AH23848, AH23848(-), ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AH23848

  • Pretreatment with AH23848 30 min before coronary artery occlusion reduced the number of ischaemia-induced extrasystoles to 339 +/- 111 compared with 736 +/- 153 in the control group [1].
  • Late intervention with AH23848, 25 min after the onset of myocardial ischaemia did not significantly alter the incidence of reperfusion-induced ventricular fibrillation; 70% of the control group died and 60% of those that received AH23848 [1].
  • Administration of both an EP4 antagonist [AH23848, (4Z)-7-[(rel-1S,2S,5R)-5-((1,1'-biphenyl-4-yl)methoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid] and EP4 knockdown with intrathecally delivered short hairpin RNA attenuates inflammation-induced thermal and mechanical behavioral hypersensitivity, without changing basal pain sensitivity [2].
  • Effect of the specific thromboxane receptor blocking drug AH23848 in patients with angina pectoris [3].

High impact information on AH23848

  • Finally, AH23848 significantly decreased the renin release by kidneys of the three strains.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
  • The formation of cAMP by PGE2 was concentration-dependently inhibited by the EP4 receptor-selective antagonist AH23848 [5].
  • The antithrombotic effect of a specific thromboxane A2 receptor blocking drug, AH23848, on radio-labelled platelet deposition in mature Dacron aorto-bifemoral grafts has been evaluated in patients [6].
  • AH23848 also reduces the PGE(2)-mediated sensitization of capsaicin-evoked currents in DRG neurons in vitro [2].
  • Since AH23848 inhibited PGE2-induced cAMP formation in U-937 cells to a similar extent as in Jurkat and KM-3, EP2 receptors seem to play, if any, only a secondary role for the PGE2-mediated cAMP formation in U-937 cells [7].

Biological context of AH23848


Anatomical context of AH23848

  • 6. The results obtained with both the agonists and the antagonist, AH23848 are therefore consistent with prostanoid-induced contractions of human bronchial smooth muscle being mediated by TP-receptors [11].
  • PGE2 increased cAMP formation with an ED50 of 50-100 nM in all cell lines. cAMP formation was inhibited by the EP4R-specific antagonist AH23848 [7].

Associations of AH23848 with other chemical compounds


Gene context of AH23848

  • The thromboxane A2 receptor antagonist AH23848 (5 mg kg-1, i.v.) inhibited pressor responses to AA in the autoperfused hindquarters, but potentiated depressor responses to AA (0.125-0.5 mg kg-1) in the whole animal [13].


  1. AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion-induced arrhythmias in anaesthetized greyhounds. Coker, S.J., Parratt, J.R. Br. J. Pharmacol. (1985) [Pubmed]
  2. Prostaglandin E2 Receptor EP4 Contributes to Inflammatory Pain Hypersensitivity. Lin, C.R., Amaya, F., Barrett, L., Wang, H., Takada, J., Samad, T.A., Woolf, C.J. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  3. Effect of the specific thromboxane receptor blocking drug AH23848 in patients with angina pectoris. De Bono, D.P., Lumley, P., Been, M., Keery, R., Ince, S.E., Woodings, D.F. British heart journal. (1986) [Pubmed]
  4. Pressure independence of renin release by isolated kidneys of Lyon hypertensive rats. Medeiros, I.A., Vincent, M., Benzoni, D., Sassard, J. Hypertension (1992) [Pubmed]
  5. Expression of prostaglandin receptors EP4 and FP in human lens epithelial cells. Mukhopadhyay, P., Bhattacherjee, P., Andom, T., Geoghegan, T.E., Andley, U.P., Paterson, C.A. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  6. A specific thromboxane receptor blocking drug, AH23848, reduces platelet deposition on vascular grafts in man. Lane, I.F., Lumley, P., Michael, M.F., Peters, A.M., McCollum, C.N. Thromb. Haemost. (1990) [Pubmed]
  7. Exclusive expression of the Gs-linked prostaglandin E2 receptor subtype 4 mRNA in mononuclear Jurkat and KM-3 cells and coexpression of subtype 4 and 2 mRNA in U-937 cells. Blaschke, V., Jungermann, K., Püschel, G.P. FEBS Lett. (1996) [Pubmed]
  8. Teratogenicity of three substituted 4-biphenyls in the rat as a result of the chemical breakdown and possible metabolism of a thromboxane A2-receptor blocker. Sutherland, M.F., Parkinson, M.M., Hallett, P. Teratology (1989) [Pubmed]
  9. Increased production of ovarian thromboxane in gonadotropin-treated immature rats: relationship to the ovulatory process. Wilken, C., Van Kirk, E.A., Slaughter, R.G., Ji, T.H., Murdoch, W.J. Prostaglandins (1990) [Pubmed]
  10. Effects of prostagladin E(2) on gel-forming mucin secretion in normal human nasal epithelial cells. Kook Kim, J., Hoon Kim, C., Kim, K., Jong Jang, H., Jik Kim, H., Yoon, J.H. Acta Otolaryngol. (2006) [Pubmed]
  11. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors. Coleman, R.A., Sheldrick, R.L. Br. J. Pharmacol. (1989) [Pubmed]
  12. The role of thromboxane in the uterotrophic response in the gravid normotensive and spontaneously hypertensive rat. Kerr, M.B., Marshall, K., Senior, J. J. Endocrinol. (1992) [Pubmed]
  13. Changes in cardiovascular sensitivity of alloxan-treated diabetic rats to arachidonic acid. Boura, A.L., Hodgson, W.C., King, R.G. Br. J. Pharmacol. (1986) [Pubmed]
WikiGenes - Universities