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Chemical Compound Review

Ac-Yvad-cho     (3S)-3-[[(2S)-2-[[(2S)-2- [[(2S)-2...

Synonyms: CHEMBL37630, AC1NSK2K, DNC009145, L-709049, NCGC00167338-01, ...
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High impact information on Ac-Yvad-cho


Biological context of Ac-Yvad-cho

  • Cysteine protease inhibitors (E-64, leupeptin, Ac-YVAD-CHO [ICE inhibitor]) did not affect camptothecin-induced DNA fragmentation [6].
  • Intravitreal injection of a caspase-1 inhibitor, acetyl-tyrosyl-valyl-alanyl-aspartic-aldehyde (Ac-YVAD-CHO), at postnatal days 21 (P21) and P26 was performed to see if this caused a decrease in apoptotic cell number at P28 [7].
  • To characterize the mode of cell death induced by the inhibition of caspase-3, we have studied the effects of Ac-DEVD-CHO, Ac-YVAD-CHO, and Ac-IETD-CHO, inhibitors of caspases, on structural changes in X-irradiated human leukemic MOLT-4 cells [8].

Anatomical context of Ac-Yvad-cho


Associations of Ac-Yvad-cho with other chemical compounds


Gene context of Ac-Yvad-cho


Analytical, diagnostic and therapeutic context of Ac-Yvad-cho


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  7. Caspaselike proteases activated in apoptotic photoreceptors of Royal College of Surgeons rats. Katai, N., Kikuchi, T., Shibuki, H., Kuroiwa, S., Arai, J., Kurokawa, T., Yoshimura, N. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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  9. Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner. Hirota, J., Furuichi, T., Mikoshiba, K. J. Biol. Chem. (1999) [Pubmed]
  10. Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3. Yue, T.L., Wang, C., Romanic, A.M., Kikly, K., Keller, P., DeWolf, W.E., Hart, T.K., Thomas, H.C., Storer, B., Gu, J.L., Wang, X., Feuerstein, G.Z. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  11. Chronic hepatitis in interferon-gamma transgenic mice is associated with elevated CPP32-like activity and interleukin-1beta-converting enzyme activity suppression. Okamoto, T., Nakano, Y., Yamakawa, T., Hara, K., Yamamura, K.I., Hino, O. Jpn. J. Pharmacol. (1999) [Pubmed]
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  14. Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons. Petersén, A., Castilho, R.F., Hansson, O., Wieloch, T., Brundin, P. Brain Res. (2000) [Pubmed]
  15. Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. Kusuhara, H., Matsuyuki, H., Matsuura, M., Imayoshi, T., Okumoto, T., Matsui, H. Eur. J. Pharmacol. (1998) [Pubmed]
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  17. T cell-dependent secretion of IL-1 beta by a dendritic cell line (XS52) derived from murine epidermis. Kitajima, T., Ariizumi, K., Mohamadazadeh, M., Edelbaum, D., Bergstresser, P.R., Takashima, A. J. Immunol. (1995) [Pubmed]
  18. c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells. Biroccio, A., Benassi, B., Amodei, S., Gabellini, C., Del Bufalo, D., Zupi, G. Mol. Pharmacol. (2001) [Pubmed]
  19. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Cao, Y., Gu, Z.L., Lin, F., Han, R., Qin, Z.H. Acta Pharmacol. Sin. (2005) [Pubmed]
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