The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Ac-Yvad-cho     (3S)-3-[[(2S)-2-[[(2S)-2- [[(2S)-2...

Synonyms: CHEMBL37630, AC1NSK2K, DNC009145, L-709049, NCGC00167338-01, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Ac-Yvad-cho

 

Biological context of Ac-Yvad-cho

  • Cysteine protease inhibitors (E-64, leupeptin, Ac-YVAD-CHO [ICE inhibitor]) did not affect camptothecin-induced DNA fragmentation [6].
  • Intravitreal injection of a caspase-1 inhibitor, acetyl-tyrosyl-valyl-alanyl-aspartic-aldehyde (Ac-YVAD-CHO), at postnatal days 21 (P21) and P26 was performed to see if this caused a decrease in apoptotic cell number at P28 [7].
  • To characterize the mode of cell death induced by the inhibition of caspase-3, we have studied the effects of Ac-DEVD-CHO, Ac-YVAD-CHO, and Ac-IETD-CHO, inhibitors of caspases, on structural changes in X-irradiated human leukemic MOLT-4 cells [8].
 

Anatomical context of Ac-Yvad-cho

 

Associations of Ac-Yvad-cho with other chemical compounds

 

Gene context of Ac-Yvad-cho

 

Analytical, diagnostic and therapeutic context of Ac-Yvad-cho

References

  1. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). Medema, J.P., Scaffidi, C., Kischkel, F.C., Shevchenko, A., Mann, M., Krammer, P.H., Peter, M.E. EMBO J. (1997) [Pubmed]
  2. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. Dubrez, L., Savoy, I., Hamman, A., Solary, E. EMBO J. (1996) [Pubmed]
  3. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Du, Y., Bales, K.R., Dodel, R.C., Hamilton-Byrd, E., Horn, J.W., Czilli, D.L., Simmons, L.K., Ni, B., Paul, S.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members. Rathbun, R.K., Christianson, T.A., Faulkner, G.R., Jones, G., Keeble, W., O'Dwyer, M., Bagby, G.C. Blood (2000) [Pubmed]
  5. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Kakeya, H., Onose, R., Osada, H. Cancer Res. (1998) [Pubmed]
  6. DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies. Shimizu, T., Pommier, Y. Exp. Cell Res. (1996) [Pubmed]
  7. Caspaselike proteases activated in apoptotic photoreceptors of Royal College of Surgeons rats. Katai, N., Kikuchi, T., Shibuki, H., Kuroiwa, S., Arai, J., Kurokawa, T., Yoshimura, N. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  8. Time sequence analysis of caspase-3-independent programmed cell death and apoptosis in X-irradiated human leukemic MOLT-4 cells. Nakano, H., Shinohara, K. Cell Tissue Res. (2002) [Pubmed]
  9. Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner. Hirota, J., Furuichi, T., Mikoshiba, K. J. Biol. Chem. (1999) [Pubmed]
  10. Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3. Yue, T.L., Wang, C., Romanic, A.M., Kikly, K., Keller, P., DeWolf, W.E., Hart, T.K., Thomas, H.C., Storer, B., Gu, J.L., Wang, X., Feuerstein, G.Z. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  11. Chronic hepatitis in interferon-gamma transgenic mice is associated with elevated CPP32-like activity and interleukin-1beta-converting enzyme activity suppression. Okamoto, T., Nakano, Y., Yamakawa, T., Hara, K., Yamamura, K.I., Hino, O. Jpn. J. Pharmacol. (1999) [Pubmed]
  12. Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling. Kim, Y.M., Chung, H.T., Kim, S.S., Han, J.A., Yoo, Y.M., Kim, K.M., Lee, G.H., Yun, H.Y., Green, A., Li, J., Simmons, R.L., Billiar, T.R. J. Neurosci. (1999) [Pubmed]
  13. Up-regulation of ICH-1L protein by thromboxane A2 antagonists enhances cisplatin-induced apoptosis in non-small-cell lung-cancer cell lines. Fujimura, M., Kasahara, K., Shirasaki, H., Heki, U., Iwasa, K., Ueda, A., Matsuda, T. J. Cancer Res. Clin. Oncol. (1999) [Pubmed]
  14. Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons. Petersén, A., Castilho, R.F., Hansson, O., Wieloch, T., Brundin, P. Brain Res. (2000) [Pubmed]
  15. Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. Kusuhara, H., Matsuyuki, H., Matsuura, M., Imayoshi, T., Okumoto, T., Matsui, H. Eur. J. Pharmacol. (1998) [Pubmed]
  16. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Kugawa, F., Ueno, A., Aoki, M. Biol. Pharm. Bull. (2000) [Pubmed]
  17. T cell-dependent secretion of IL-1 beta by a dendritic cell line (XS52) derived from murine epidermis. Kitajima, T., Ariizumi, K., Mohamadazadeh, M., Edelbaum, D., Bergstresser, P.R., Takashima, A. J. Immunol. (1995) [Pubmed]
  18. c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells. Biroccio, A., Benassi, B., Amodei, S., Gabellini, C., Del Bufalo, D., Zupi, G. Mol. Pharmacol. (2001) [Pubmed]
  19. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Cao, Y., Gu, Z.L., Lin, F., Han, R., Qin, Z.H. Acta Pharmacol. Sin. (2005) [Pubmed]
  20. Involvement of caspases in sympathetic neuron apoptosis. McCarthy, M.J., Rubin, L.L., Philpott, K.L. J. Cell. Sci. (1997) [Pubmed]
  21. Human parvovirus B19 nonstructural (NS1) protein induces apoptosis in erythroid lineage cells. Moffatt, S., Yaegashi, N., Tada, K., Tanaka, N., Sugamura, K. J. Virol. (1998) [Pubmed]
  22. Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism. Zhou, X., Gordon, S.A., Kim, Y.M., Hoffman, R.A., Chen, Y., Zhang, X.R., Simmons, R.L., Ford, H.R. J. Immunol. (2000) [Pubmed]
 
WikiGenes - Universities