Disease relevance of Pathology, Clinical

• In addition, there is no reactivity with the structurally homologous proteins calmodulin and troponin C. The utility of these monoclonal antibodies for immunocytochemical studies of clinical pathology specimens has been demonstrated by examination of S100 beta localization in human autopsy brain and anaplastic astrocytoma sections [1].
• Since many of the chemoattractant receptors regulated by cADPR bind to ligands that are associated with clinical pathology, cADPR and CD38 represent novel drug targets with potential application in chronic inflammatory and neurodegenerative disease [2].
• Administration of 180 mg of ICN 17261 per kg of body weight to rats by oral gavage for 4 weeks generated substantial serum levels of drug but no observable clinical pathology, whereas equivalent doses of ribavirin induced a significant anemia and leukopenia [3].
• In definitive safety studies, there were no adverse findings related to neotame treatment from clinical observations, physical examinations, water consumption, or clinical pathology evaluations; nor was there morbidity, mortality, organ toxicity, macroscopic or microscopic postmortem findings [4].
• ACP Best Practice No 181: Chemical pathology clinical investigation and management of nephrolithiasis [5].

Psychiatry related information on Pathology, Clinical

• Single photon emission computerized tomography (SPECT) studies were performed on 34 manifest Huntington's disease (HD) patients at various stages of clinical pathology ranging from early chorea to late dystonia with or without signs of dementia and 12 pre-symptomatic patients with abnormal terminal CAG expansions [6].

High impact information on Pathology, Clinical

• Four sets of such twins are examined, each set having one individual with clinically active, seropositive rheumatoid arthritis and another without detectable rheumatoid factor or clinical pathology [7].
• In the present study, we describe the development and validation of a biochip-based assay designed to provide a comprehensive molecular analysis of MLL rearrangements when used in a standard clinical pathology laboratory [8].
• Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma [9].
• Although much is known about the clinical pathology of AAT deficiency, researchers are just beginning to characterize environmental, occupational, and genetic modifiers affecting the onset and progression of diseases related to AAT deficiency [10].
• As in other species, alterations in clinical pathology reflect hepatic injury as well as elevated serum cholesterol concentration [11].

Chemical compound and disease context of Pathology, Clinical

• Mice were treated for 15, 30, 45, or 90 days, at which time they were evaluated for feed consumption, liver/body weight ratios, clinical pathology, serum oxazepam levels, and histopathology of the liver [12].
• Overall health, body weight, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, gross and microscopic appearance of tissues were comparable between groups fed diets containing Roundup Ready and control corn grain [13].
• End-points included histopathology, CO-oximetry, plasma nicotine and cotinine, clinical pathology, and organ and body weights [14].

Biological context of Pathology, Clinical

• The utility of pairing clinical pathology assessments with gene expression data is illustrated using three anti-neoplastic drugs: carmustine, methotrexate, and thioguanine, which had similar effects on the blood compartment, but diverse effects on hepatotoxicity [15].
• Clinical condition, ophthalmic findings, palpable mass occurrence, body composition, clinical pathology parameters and incidence of neoplastic lesions were unaffected by DAG in comparison to TG [16].
• Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology [17].
• In Indonesia EQAS for blood coagulation is organized by the Department of Clinical Pathology, Faculty of Medicine, University of Indonesia which cooperates with the Indonesian Society of Clinical Pathologists, Jakarta Chapter [18].

Anatomical context of Pathology, Clinical

• The results of our study reveal that the nitrite and leukocyte esterase assays miss significant microscopic findings with corresponding clinical pathology, with the nitrite examination being the less sensitive of the two tests [19].

Associations of Pathology, Clinical with chemical compounds

• The method is simple, sensitive, reproducible (between-run coefficient of variation of 6.6%) and very suitable for routine determination of serum homocysteine levels in a clinical pathology laboratory [20].
• There were no changes in clinical pathology tests, urine analyses or electrocardiograms after dosing with idrapril calcium [21].
• A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol [22].
• Local and systemic tobramycin levels, pellet resorption, bone response, clinical pathology parameters, and histopathologic responses of potential target organs were analyzed to determine if there was any adverse response for a 28-day period [23].
• Blood glucose values were elevated in 12 of 30 baboons with available clinical pathology data [24].

Gene context of Pathology, Clinical

• MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy [25].
• Clinical pathology is mediated in part by the production of pyrogenic cytokines, especially interleukin (IL)-1, tumor necrosis factor (TNF)-alpha, and IL-6 [26].
• Early ERP components are valuable tools in clinical testing of the afferent sensory systems in the absence of anamnestic or clinical pathology [27].
• This article describes a new set of revised standards for the medical laboratory, which have been produced by Clinical Pathology Accreditation (UK) Ltd (CPA) [28].
• In this study, a total of 120 mycobacterial strains isolated from clinical specimens in Hacettepe University Hospital Clinical Pathology Laboratories were evaluated by polymerase chain reaction-restriction enzyme analysis (PRA), which analyses the common mycobacterial heat shock protein gene (hsp65) [29].

Analytical, diagnostic and therapeutic context of Pathology, Clinical

• Consensus report of the task force on standardisation of DNA flow cytometry in clinical pathology. DNA Flow Cytometry Task Force of the European Society for Analytical Cellular Pathology [30].
• Out of a wide range of assays that have been used in research for the detection of HER2 status, only two techniques are now predominant and readily applicable in the routine clinical pathology laboratory: determination of HER2 overexpression by immunohistochemistry (IHC) and HER2 gene amplification by fluorescence in situ hybridisation (FISH) [31].

References