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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pathology, Clinical

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Disease relevance of Pathology, Clinical


Psychiatry related information on Pathology, Clinical


High impact information on Pathology, Clinical

  • Four sets of such twins are examined, each set having one individual with clinically active, seropositive rheumatoid arthritis and another without detectable rheumatoid factor or clinical pathology [7].
  • In the present study, we describe the development and validation of a biochip-based assay designed to provide a comprehensive molecular analysis of MLL rearrangements when used in a standard clinical pathology laboratory [8].
  • Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma [9].
  • Although much is known about the clinical pathology of AAT deficiency, researchers are just beginning to characterize environmental, occupational, and genetic modifiers affecting the onset and progression of diseases related to AAT deficiency [10].
  • As in other species, alterations in clinical pathology reflect hepatic injury as well as elevated serum cholesterol concentration [11].

Chemical compound and disease context of Pathology, Clinical


Biological context of Pathology, Clinical


Anatomical context of Pathology, Clinical

  • The results of our study reveal that the nitrite and leukocyte esterase assays miss significant microscopic findings with corresponding clinical pathology, with the nitrite examination being the less sensitive of the two tests [19].

Associations of Pathology, Clinical with chemical compounds

  • The method is simple, sensitive, reproducible (between-run coefficient of variation of 6.6%) and very suitable for routine determination of serum homocysteine levels in a clinical pathology laboratory [20].
  • There were no changes in clinical pathology tests, urine analyses or electrocardiograms after dosing with idrapril calcium [21].
  • A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol [22].
  • Local and systemic tobramycin levels, pellet resorption, bone response, clinical pathology parameters, and histopathologic responses of potential target organs were analyzed to determine if there was any adverse response for a 28-day period [23].
  • Blood glucose values were elevated in 12 of 30 baboons with available clinical pathology data [24].

Gene context of Pathology, Clinical

  • MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy [25].
  • Clinical pathology is mediated in part by the production of pyrogenic cytokines, especially interleukin (IL)-1, tumor necrosis factor (TNF)-alpha, and IL-6 [26].
  • Early ERP components are valuable tools in clinical testing of the afferent sensory systems in the absence of anamnestic or clinical pathology [27].
  • This article describes a new set of revised standards for the medical laboratory, which have been produced by Clinical Pathology Accreditation (UK) Ltd (CPA) [28].
  • In this study, a total of 120 mycobacterial strains isolated from clinical specimens in Hacettepe University Hospital Clinical Pathology Laboratories were evaluated by polymerase chain reaction-restriction enzyme analysis (PRA), which analyses the common mycobacterial heat shock protein gene (hsp65) [29].

Analytical, diagnostic and therapeutic context of Pathology, Clinical


  1. Production and characterization of monoclonal antibodies with specificity for the S100 beta polypeptide of brain S100 fractions. Van Eldik, L.J., Ehrenfried, B., Jensen, R.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  2. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose. Partida-Sánchez, S., Iribarren, P., Moreno-García, M.E., Gao, J.L., Murphy, P.M., Oppenheimer, N., Wang, J.M., Lund, F.E. J. Immunol. (2004) [Pubmed]
  3. The ribavirin analog ICN 17261 demonstrates reduced toxicity and antiviral effects with retention of both immunomodulatory activity and reduction of hepatitis-induced serum alanine aminotransferase levels. Tam, R.C., Ramasamy, K., Bard, J., Pai, B., Lim, C., Averett, D.R. Antimicrob. Agents Chemother. (2000) [Pubmed]
  4. Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies. Mayhew, D.A., Comer, C.P., Stargel, W.W. Regulatory toxicology and pharmacology : RTP. (2003) [Pubmed]
  5. ACP Best Practice No 181: Chemical pathology clinical investigation and management of nephrolithiasis. Reynolds, T.M. J. Clin. Pathol. (2005) [Pubmed]
  6. Single photon emission computerized tomography (SPECT) in detecting neurodegeneration in Huntington's disease. Reynolds, N.C., Hellman, R.S., Tikofsky, R.S., Prost, R.W., Mark, L.P., Elejalde, B.R., Lebel, R., Hamsher, K.S., Swanson, S., Benezra, E.E. Nuclear medicine communications. (2002) [Pubmed]
  7. Genetic influence on the levels of circulating CD5 B lymphocytes. Kipps, T.J., Vaughan, J.H. J. Immunol. (1987) [Pubmed]
  8. A diagnostic biochip for the comprehensive analysis of MLL translocations in acute leukemia. Maroc, N., Morel, A., Beillard, E., De La Chapelle, A.L., Fund, X., Mozziconacci, M.J., Dupont, M., Cayuela, J.M., Gabert, J., Koki, A., Fert, V., Hermitte, F. Leukemia (2004) [Pubmed]
  9. Production and characterization of a mouse/human chimeric antibody directed against human neuroblastoma. Amstutz, H., Rytz, C., Novak-Hofer, I., Spycher, M., Schubiger, P.A., Blaser, K., Morgenthaler, J.J. Int. J. Cancer (1993) [Pubmed]
  10. Environmental, occupational, and genetic risk factors for alpha-1 antitrypsin deficiency. Sharp, R.R., de Serres, F., Newman, L., Sandhaus, R.A., Walsh, J.W., Hood, E., Harry, G.J. Environ. Health Perspect. (2003) [Pubmed]
  11. Fumonisin toxicosis in swine: an overview of porcine pulmonary edema and current perspectives. Haschek, W.M., Gumprecht, L.A., Smith, G., Tumbleson, M.E., Constable, P.D. Environ. Health Perspect. (2001) [Pubmed]
  12. Early responses of the liver of B6C3F1 mice to the hepatocarcinogen oxazepam. Cunningham, M.L., Maronpot, R.R., Thompson, M., Bucher, J.R. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  13. Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn. Hammond, B., Dudek, R., Lemen, J., Nemeth, M. Food Chem. Toxicol. (2004) [Pubmed]
  14. Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. I. Inhalation toxicology and histopathology. Coggins, C.R., Ayres, P.H., Mosberg, A.T., Ogden, M.W., Sagartz, J.W., Hayes, A.W. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1992) [Pubmed]
  15. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. Ganter, B., Tugendreich, S., Pearson, C.I., Ayanoglu, E., Baumhueter, S., Bostian, K.A., Brady, L., Browne, L.J., Calvin, J.T., Day, G.J., Breckenridge, N., Dunlea, S., Eynon, B.P., Furness, L.M., Ferng, J., Fielden, M.R., Fujimoto, S.Y., Gong, L., Hu, C., Idury, R., Judo, M.S., Kolaja, K.L., Lee, M.D., McSorley, C., Minor, J.M., Nair, R.V., Natsoulis, G., Nguyen, P., Nicholson, S.M., Pham, H., Roter, A.H., Sun, D., Tan, S., Thode, S., Tolley, A.M., Vladimirova, A., Yang, J., Zhou, Z., Jarnagin, K. J. Biotechnol. (2005) [Pubmed]
  16. A 24-month dietary carcinogenicity study of DAG (diacylglycerol) in rats. Chengelis, C.P., Kirkpatrick, J.B., Bruner, R.H., Freshwater, L., Morita, O., Tamaki, Y., Suzuki, H. Food Chem. Toxicol. (2006) [Pubmed]
  17. Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology. Cui, J., Yang, D.H., Bi, X.J., Fan, Z.R. World J. Gastroenterol. (2001) [Pubmed]
  18. External quality assessment scheme for blood coagulation. Setiabudy, R., Silman, E. Southeast Asian J. Trop. Med. Public Health (2002) [Pubmed]
  19. Reliability of a urine dipstick in emergency department patients. Propp, D.A., Weber, D., Ciesla, M.L. Annals of emergency medicine. (1989) [Pubmed]
  20. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. Ubbink, J.B., Hayward Vermaak, W.J., Bissbort, S. J. Chromatogr. (1991) [Pubmed]
  21. Pharmacokinetics and biochemical efficacy of idrapril calcium, a novel ACE inhibitor, after multiple oral administration in humans. Wyld, P.J., Grant, J., Lippi, A., Criscuoli, M., Del Re, G., Subissi, A. British journal of clinical pharmacology. (1994) [Pubmed]
  22. A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol. Graham, J.S., Reid, F.M., Smith, J.R., Stotts, R.R., Tucker, E.S., Shumaker, S.M., Niemuth, N.A., Janny, S.J. Journal of applied toxicology : JAT. (2000) [Pubmed]
  23. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Turner, T.M., Urban, R.M., Hall, D.J., Chye, P.C., Segreti, J., Gitelis, S. Clin. Orthop. Relat. Res. (2005) [Pubmed]
  24. Spontaneous pancreatic islet amyloidosis in 40 baboons. Hubbard, G.B., Steele, K.E., Davis, K.J., Leland, M.M. J. Med. Primatol. (2002) [Pubmed]
  25. MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Rayburn, E., Zhang, R., He, J., Wang, H. Current cancer drug targets. (2005) [Pubmed]
  26. Proinflammatory cytokine profiles in pulp fibroblasts stimulated with lipopolysaccharide and methyl mercaptan. Coil, J., Tam, E., Waterfield, J.D. Journal of endodontics. (2004) [Pubmed]
  27. Event-related potentials of the brain and cognitive processes: approaches and applications. Brandeis, D., Lehmann, D. Neuropsychologia. (1986) [Pubmed]
  28. Clinical pathology accreditation: standards for the medical laboratory. Burnett, D., Blair, C., Haeney, M.R., Jeffcoate, S.L., Scott, K.W., Williams, D.L. J. Clin. Pathol. (2002) [Pubmed]
  29. Evaluation of 120 mycobacterial strains isolated from clinical specimens to the species level by polymerase chain reaction-restriction enzyme analysis. Ergin, A., Kocagöz, T., Us, D. Scand. J. Infect. Dis. (2000) [Pubmed]
  30. Consensus report of the task force on standardisation of DNA flow cytometry in clinical pathology. DNA Flow Cytometry Task Force of the European Society for Analytical Cellular Pathology. Ormerod, M.G., Tribukait, B., Giaretti, W. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. (1998) [Pubmed]
  31. Comparison of chromogenic in situ hybridization with other methodologies for HER2 status assessment in breast cancer. Hauser-Kronberger, C., Dandachi, N. J. Mol. Histol. (2004) [Pubmed]
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