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Chemical Compound Review

Ranatensin     (2S)-N-[(1S)-1-[[(1S)-1-[[1- [[(1S)-1...

Synonyms: AC1NUR1N, 29451-71-6
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Disease relevance of Ranatensin

  • GRP, the mammalian homolog of bombesin and its receptor, as well as NMB, the mammalian homolog of ranatensin, are expressed in human neoplasms and, in particular, in small cell lung carcinomas (SCLC) [1].

High impact information on Ranatensin

  • The low molecular weight BN-GRP-LI extracted from spinal cord was more hydrophilic than bombesin or ranatensin [2].
  • Sequence homology showed that the fGRP precursor is more homology showed that the fGRP precursor is more closely related to the mammalian GRP precursors than to either the frog bombesin or frog ranatensin precursors [3].
  • The amidated decapeptide neuromedin B (NMB) is the mammalian homolog of the amphibian bombesin-like peptide ranatensin. cDNAs encoding human neuromedin B and amphibian ranatensin were isolated from human hypothalamic and Rana pipiens skin libraries, respectively [4].
  • Phylogenetic analysis of bombesin-like peptide prohormone sequences showed that the phyllolitorin prohormones are much more closely related to the bombesin and ranatensin prohormones than to the GRP and NMB prohormones [5].
  • It is concluded that bombesin- and ranatensin-like peptides have a stimulatory effect on GH and PRL release at the pituitary level [6].

Biological context of Ranatensin


Anatomical context of Ranatensin


Associations of Ranatensin with other chemical compounds

  • Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin [4].
  • The lengths of incubation time required to produce approximately 90% degradation of peptide immunoreactivity varied across peptides from less than 5 min (SP) to more than 60 min (BN and RT) [14].

Gene context of Ranatensin

  • Sequence analysis revealed that NMB is encoded in a 76-amino acid precursor and ranatensin in an 82-amino acid precursor [4].
  • Biochemical and histochemical characterization of ranatensin immunoreactive peptides in rat brain: lack of coexistence with bombesin/GRP [15].

Analytical, diagnostic and therapeutic context of Ranatensin


  1. Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. Giladi, E., Nagalla, S.R., Spindel, E.R. J. Mol. Neurosci. (1993) [Pubmed]
  2. Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons. Panula, P., Hadjiconstantinou, M., Yang, H.Y., Costa, E. J. Neurosci. (1983) [Pubmed]
  3. Gastrin-releasing peptide (GRP) is not mammalian bombesin. Identification and molecular cloning of a true amphibian GRP distinct from amphibian bombesin in Bombina orientalis. Nagalla, S.R., Gibson, B.W., Tang, D., Reeve, J.R., Spindel, E.R. J. Biol. Chem. (1992) [Pubmed]
  4. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. Krane, I.M., Naylor, S.L., Helin-Davis, D., Chin, W.W., Spindel, E.R. J. Biol. Chem. (1988) [Pubmed]
  5. Cloning of complementary DNAs encoding the amphibian bombesin-like peptides Phe8 and Leu8 phyllolitorin from Phyllomedusa sauvagei: potential role of U to C RNA editing in generating neuropeptide diversity. Nagalla, S.R., Barry, B.J., Spindel, E.R. Mol. Endocrinol. (1994) [Pubmed]
  6. Stimulation of growth hormone and prolactin release from rat pituitary cell aggregates by bombesin- and ranatensin-like peptides is potentiated by estradiol, 5 alpha-dihydrotestosterone, and dexamethasone. Houben, H., Denef, C. Endocrinology (1990) [Pubmed]
  7. Presence of ranatensin-like and bombesin-like peptides in amphibian brains. Walsh, J.H., Lechago, J., Wong, H.C., Rosenquist, G.L. Regul. Pept. (1982) [Pubmed]
  8. Characterization of bombesin receptors on canine antral gastrin cells. Vigna, S.R., Giraud, A.S., Mantyh, P.W., Soll, A.H., Walsh, J.H. Peptides (1990) [Pubmed]
  9. Molecular biology of bombesin-like peptides. Comparison of cDNAs encoding human gastrin-releasing peptide, human neuromedin B, and amphibian ranatensin. Spindel, E.R., Krane, I.M. Ann. N. Y. Acad. Sci. (1988) [Pubmed]
  10. Intracisternal bombesin induced inhibition of gastric secretion is not mediated through prostaglandin or opioid pathways. Taché, Y. Peptides (1985) [Pubmed]
  11. Six novel tachykinin- and bombesin-related peptides from the skin of the Australian frog Pseudophryne güntheri. Simmaco, M., Severini, C., De Biase, D., Barra, D., Bossa, F., Roberts, J.D., Melchiorri, P., Erspamer, V. Peptides (1990) [Pubmed]
  12. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Yasuhara, T., Ishikawa, O., Nakajima, T. Chem. Pharm. Bull. (1979) [Pubmed]
  13. Localization of receptors for bombesin-like peptides in the rat brain. Moody, T.W., Getz, R., O'Donohue, T.L., Rosenstein, J.M. Ann. N. Y. Acad. Sci. (1988) [Pubmed]
  14. Peptide transmitters of primary sensory neurons: similar actions of tachykinins and bombesin-like peptides. Bishop, J.F., Moody, T.W., O'Donohue, T.L. Peptides (1986) [Pubmed]
  15. Biochemical and histochemical characterization of ranatensin immunoreactive peptides in rat brain: lack of coexistence with bombesin/GRP. Chronwall, B.M., Pisano, J.J., Bishop, J.F., Moody, T.W., O'Donohue, T.L. Brain Res. (1985) [Pubmed]
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