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Chemical Compound Review

Neuromedin B     (2S)-N-[(1S)-1-[[(1S)-1- [[(1S)-1-[[(1S,2R)...

Synonyms: AC1NUOG5, Neuromedin B (swine spinal cord), Gly-asn-leu-trp-ala-thr-gly-his-phe-met-NH2
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Disease relevance of Neuromedin B


Psychiatry related information on Neuromedin B

  • Similar administration of neuromedin B had a biphasic effect; there was a dose-dependent decrease in reaction time lasting about 6 min followed by a delayed increase in reaction time to above control values at 31-46 min [6].

High impact information on Neuromedin B


Chemical compound and disease context of Neuromedin B


Biological context of Neuromedin B


Anatomical context of Neuromedin B


Associations of Neuromedin B with other chemical compounds


Gene context of Neuromedin B

  • Neuromedin B (NMB) is one of the bombesin (BN)-related peptides in mammals [26].
  • In all of the cases, the receptors corresponded to the GRP receptor subtype of bombesin receptors, having high affinity for GRP and bombesin and lower affinity for neuromedin B [27].
  • Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor [28].
  • The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding [29].
  • The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis [30].

Analytical, diagnostic and therapeutic context of Neuromedin B


  1. Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Battey, J.F., Way, J.M., Corjay, M.H., Shapira, H., Kusano, K., Harkins, R., Wu, J.M., Slattery, T., Mann, E., Feldman, R.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Neuromedin B is present in lung cancer cell lines. Giaccone, G., Battey, J., Gazdar, A.F., Oie, H., Draoui, M., Moody, T.W. Cancer Res. (1992) [Pubmed]
  3. Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells. Charlesworth, A., Rozengurt, E. Oncogene (1997) [Pubmed]
  4. Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides. Wang, L.H., Battey, J.F., Wada, E., Lin, J.T., Mantey, S., Coy, D.H., Jensen, R.T. Biochem. J. (1992) [Pubmed]
  5. Localization of 7B2, neuromedin B, and neuromedin U in specific cell types of rat, mouse, and human pituitary, in rat hypothalamus, and in 30 human pituitary and extrapituitary tumors. Steel, J.H., Van Noorden, S., Ballesta, J., Gibson, S.J., Ghatei, M.A., Burrin, J., Leonhardt, U., Domin, J., Bloom, S.R., Polak, J.M. Endocrinology (1988) [Pubmed]
  6. Bombesin, neuromedin C and neuromedin B given intrathecally facilitate the tail flick reflex in the rat. Cridland, R.A., Henry, J.L. Brain Res. (1992) [Pubmed]
  7. Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction. Bitar, K.N., Zhu, X.X. Gastroenterology (1993) [Pubmed]
  8. Selective reconstitution of gastrin-releasing peptide receptor with G alpha q. Hellmich, M.R., Battey, J.F., Northup, J.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Cloning of a receptor for amphibian [Phe13]bombesin distinct from the receptor for gastrin-releasing peptide: identification of a fourth bombesin receptor subtype (BB4). Nagalla, S.R., Barry, B.J., Creswick, K.C., Eden, P., Taylor, J.T., Spindel, E.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. Isolation and sequence of a cDNA encoding the precursor of a bombesinlike peptide from brain and early embryos of Xenopus laevis. Wechselberger, C., Kreil, G., Richter, K. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Role of neuromedin B in the control of the release of thyrotropin in the rat. Rettori, V., Milenkovic, L., Fahim, A.M., Polak, J., Bloom, S.R., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  12. Neuromedin B stimulates arachidonic acid release, c-fos gene expression, and the growth of C6 glioma cells. Moody, T.W., Fagarasan, M., Zia, F. Peptides (1995) [Pubmed]
  13. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. Cardona, C., Rabbitts, P.H., Spindel, E.R., Ghatei, M.A., Bleehen, N.M., Bloom, S.R., Reeve, J.G. Cancer Res. (1991) [Pubmed]
  14. The cDNA of the human neuromedin B gene (NMB) mapped to 15q11-qter recognizes an XbaI RFLP. Gregory, C.A., Schwartz, J.S. Nucleic Acids Res. (1991) [Pubmed]
  15. Androgen control of gene expression in the mouse meibomian gland. Schirra, F., Suzuki, T., Richards, S.M., Jensen, R.V., Liu, M., Lombardi, M.J., Rowley, P., Treister, N.S., Sullivan, D.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  16. Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Ladenheim, E.E., Taylor, J.E., Coy, D.H., Moran, T.H. Eur. J. Pharmacol. (1994) [Pubmed]
  17. Distinct distributions of two bombesin receptor subtypes in the rat central nervous system. Ladenheim, E.E., Jensen, R.T., Mantey, S.A., Moran, T.H. Brain Res. (1992) [Pubmed]
  18. High affinity binding sites for gastrin releasing peptide on human gastric cancer and Ménétrier's mucosa. Preston, S.R., Woodhouse, L.F., Jones-Blackett, S., Wyatt, J.I., Primrose, J.N. Cancer Res. (1993) [Pubmed]
  19. Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors. Benya, R.V., Wada, E., Battey, J.F., Fathi, Z., Wang, L.H., Mantey, S.A., Coy, D.H., Jensen, R.T. Mol. Pharmacol. (1992) [Pubmed]
  20. Bombesin receptors inhibit G protein-coupled inwardly rectifying K+ channels expressed in Xenopus oocytes through a protein kinase C-dependent pathway. Stevens, E.B., Shah, B.S., Pinnock, R.D., Lee, K. Mol. Pharmacol. (1999) [Pubmed]
  21. Evidence for neuromedin-B synthesis in the rat anterior pituitary gland. Jones, P.M., Withers, D.J., Ghatei, M.A., Bloom, S.R. Endocrinology (1992) [Pubmed]
  22. Increased hypothalamic neuropeptide Y concentrations in diabetic rat. Williams, G., Steel, J.H., Cardoso, H., Ghatei, M.A., Lee, Y.C., Gill, J.S., Burrin, J.M., Polak, J.M., Bloom, S.R. Diabetes (1988) [Pubmed]
  23. Bombesin excites a subpopulation of 5-hydroxytryptamine-sensitive neurones in the rat dorsal raphe nucleus in vitro. Pinnock, R.D., Woodruff, G.N. J. Physiol. (Lond.) (1991) [Pubmed]
  24. Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells. Giacchetti, S., Gauvillé, C., de Crémoux, P., Bertin, L., Berthon, P., Abita, J.P., Cuttitta, F., Calvo, F. Int. J. Cancer (1990) [Pubmed]
  25. Role of neuromedin B in the in vitro thyrotropin release in response to thyrotropin-releasing hormone from anterior pituitaries of eu-, hypo-, and hyperthyroid rats. Pazos-Moura, C.C., Moura, E.G., Rettori, V., Polak, J., McCann, S.M. Proc. Soc. Exp. Biol. Med. (1996) [Pubmed]
  26. Neuromedin B. Ohki-Hamazaki, H. Prog. Neurobiol. (2000) [Pubmed]
  27. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Markwalder, R., Reubi, J.C. Cancer Res. (1999) [Pubmed]
  28. Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. Sainz, E., Akeson, M., Mantey, S.A., Jensen, R.T., Battey, J.F. J. Biol. Chem. (1998) [Pubmed]
  29. The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. Fathi, Z., Benya, R.V., Shapira, H., Jensen, R.T., Battey, J.F. J. Biol. Chem. (1993) [Pubmed]
  30. The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis. Kopan, S., Sivasubramaniam, U., Warburton, M.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  31. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. Krane, I.M., Naylor, S.L., Helin-Davis, D., Chin, W.W., Spindel, E.R. J. Biol. Chem. (1988) [Pubmed]
  32. Distribution and localization of neuromedin B-like immunoreactivity in pig, cat and rat spinal cord. Namba, M., Ghatei, M.A., Gibson, S.J., Polak, J.M., Bloom, S.R. Neuroscience (1985) [Pubmed]
  33. Presence of neuromedin B-like immunoreactivity in the brain and gut of rat and guinea-pig. Namba, M., Ghatei, M.A., Bishop, A.E., Gibson, S.J., Mann, D.J., Polak, J.M., Bloom, S.R. Peptides (1985) [Pubmed]
  34. Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord. Minamino, N., Kangawa, K., Matsuo, H. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
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