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Gene Review

NMB  -  neuromedin B

Homo sapiens

Synonyms: MGC17211, MGC2277, MGC3936, Neuromedin-B
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Disease relevance of NMB


Psychiatry related information on NMB


High impact information on NMB


Chemical compound and disease context of NMB


Biological context of NMB


Anatomical context of NMB


Associations of NMB with chemical compounds


Physical interactions of NMB


Regulatory relationships of NMB


Other interactions of NMB

  • The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding [16].
  • Therefore, the data suggest that NB receptor pathways are importantly involved in thyrotroph gene regulation and function, leading to a state where TSH release is facilitated especially in response to TRH, but probably with a less-bioactive TSH [27].
  • Insulinomas were characterised by a very high incidence of GLP-1, CCK(2) and VPAC(1) receptors, with the GLP-1 receptors expressed in a particularly high density; they expressed sst(2) in two-thirds and sst(1) in approximately half of the cases and lacked CCK(1) and NMB receptors [28].
  • Based on its map position and the putative function of the encoded peptide, NMB can be considered as a candidate gene both for BBS4 and the development of human obesity [29].
  • We examined the effect of two des-Met-bombesin analogues, [(CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3] (ICI 216140) and [D-Phe6,des-Met14]bombesin(6-14) ethylamide (DPDM-bombesin ethylamide), on neuromedin B-induced Ca2+ and [3H]arachidonate release in BALB 3T3 cells transfected with human neuromedin B receptors [30].

Analytical, diagnostic and therapeutic context of NMB


  1. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. Matusiak, D., Glover, S., Nathaniel, R., Matkowskyj, K., Yang, J., Benya, R.V. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  2. Neuromedin B binds with high affinity, elevates cytosolic calcium and stimulates the growth of small-cell lung cancer cell lines. Moody, T.W., Staley, J., Zia, F., Coy, D.H., Jensen, R.T. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  3. Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer. Siegfried, J.M., Krishnamachary, N., Gaither Davis, A., Gubish, C., Hunt, J.D., Shriver, S.P. Pulmonary pharmacology & therapeutics. (1999) [Pubmed]
  4. Bombesin receptor subtypes in human cancers: detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14). Reubi, J.C., Wenger, S., Schmuckli-Maurer, J., Schaer, J.C., Gugger, M. Clin. Cancer Res. (2002) [Pubmed]
  5. Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity. Bouchard, L., Drapeau, V., Provencher, V., Lemieux, S., Chagnon, Y., Rice, T., Rao, D.C., Vohl, M.C., Tremblay, A., Bouchard, C., Pérusse, L. Am. J. Clin. Nutr. (2004) [Pubmed]
  6. Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity. Merali, Z., B??dard, T., Andrews, N., Davis, B., McKnight, A.T., Gonzalez, M.I., Pritchard, M., Kent, P., Anisman, H. J. Neurosci. (2006) [Pubmed]
  7. Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction. Bitar, K.N., Zhu, X.X. Gastroenterology (1993) [Pubmed]
  8. Cloning of a receptor for amphibian [Phe13]bombesin distinct from the receptor for gastrin-releasing peptide: identification of a fourth bombesin receptor subtype (BB4). Nagalla, S.R., Barry, B.J., Creswick, K.C., Eden, P., Taylor, J.T., Spindel, E.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Neuromedin B. Ohki-Hamazaki, H. Prog. Neurobiol. (2000) [Pubmed]
  10. Antidisialoganglioside ricin A-chain immunotoxins show potent antitumor effects in vitro and in a disseminated human neuroblastoma severe combined immunodeficiency mouse model. Gottstein, C., Schön, G., Tawadros, S., Kube, D., Wargalla-Plate, U.C., Hansmann, M.L., Wacker, H.H., Berthold, F., Diehl, V., Engert, A. Cancer Res. (1994) [Pubmed]
  11. Neuromedin B is present in lung cancer cell lines. Giaccone, G., Battey, J., Gazdar, A.F., Oie, H., Draoui, M., Moody, T.W. Cancer Res. (1992) [Pubmed]
  12. Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. Giladi, E., Nagalla, S.R., Spindel, E.R. J. Mol. Neurosci. (1993) [Pubmed]
  13. Expression of human glutamate receptors (GluR) in neuroblastoma cell lines. Korczak, B., McWhinnie, E.A., Fletcher, E.J., Kamboj, R.K. Neuroreport (1995) [Pubmed]
  14. Vasoactive intestinal peptide: a growth promoter in neuroblastoma cells. Wollman, Y., Lilling, G., Goldstein, M.N., Fridkin, M., Gozes, I. Brain Res. (1993) [Pubmed]
  15. Two bombesin analogues discriminate between neuromedin B- and bombesin-induced calcium flux in a lung cancer cell line. Ryan, R.R., Daniel, J.L., Cowan, A. Peptides (1993) [Pubmed]
  16. The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. Fathi, Z., Benya, R.V., Shapira, H., Jensen, R.T., Battey, J.F. J. Biol. Chem. (1993) [Pubmed]
  17. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. Cardona, C., Rabbitts, P.H., Spindel, E.R., Ghatei, M.A., Bleehen, N.M., Bloom, S.R., Reeve, J.G. Cancer Res. (1991) [Pubmed]
  18. Selective in vitro targeting of GRP and NMB receptors in human tumours with the new bombesin tracer (177)Lu-AMBA. Waser, B., Eltschinger, V., Linder, K., Nunn, A., Reubi, J.C. Eur. J. Nucl. Med. Mol. Imaging (2007) [Pubmed]
  19. The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides. Cassano, G., Resta, N., Gasparre, G., Lippe, C., Guanti, G. Cancer Lett. (2001) [Pubmed]
  20. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. Krane, I.M., Naylor, S.L., Helin-Davis, D., Chin, W.W., Spindel, E.R. J. Biol. Chem. (1988) [Pubmed]
  21. Discovery of high affinity bombesin receptor subtype 3 agonists. Wu, J.M., Nitecki, D.E., Biancalana, S., Feldman, R.I. Mol. Pharmacol. (1996) [Pubmed]
  22. Characterization of ligand binding and processing by gastrin-releasing peptide receptors in a small-cell lung cancer cell line. Cardona, C., Bleehen, N.M., Reeve, J.G. Biochem. J. (1992) [Pubmed]
  23. Effects of bombesin family peptides and antagonists on guinea pig nasal mucosal secretion. Ali, M., Gawin, A.Z., Baraniuk, J.N. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  24. Effects of neuromedin B and GRP-10 on gastrin and insulin release from cultured tumor cells of a malignant gastrinoma. Kawai, K., Mukai, H., Yuzawa, K., Suzuki, S., Kuzuya, N., Fujii, K., Munekata, E., Yamashita, K. Endocrinol. Jpn. (1990) [Pubmed]
  25. Detection of NGF-receptors TrkA and p75NTR in human tumor cell lines and effect of NGF on the growth characteristic of the UT-7/EPO cell line. Westphal, G., van den Berg-Stein, S., Braun, K., Knoch, T.A., Dümmerling, M., Langowski, J., Debus, J., Friedrich, E. J. Exp. Clin. Cancer Res. (2002) [Pubmed]
  26. The increased proliferation of cultured neuroblastoma cells treated with vasoactive intestinal peptide is enhanced by simultaneous inhibition of neutral endopeptidase. Wollman, Y., Blumberg, S., Spungin, A., Brenneman, D.E., Fridkin, M., Wollman, J., Iaina, A., Gozes, I. Regul. Pept. (2002) [Pubmed]
  27. Disruption of neuromedin B receptor gene results in dysregulation of the pituitary-thyroid axis. Oliveira, K.J., Ortiga-Carvalho, T.M., Cabanelas, A., Veiga, M.A., Aoki, K., Ohki-Hamazaki, H., Wada, K., Wada, E., Pazos-Moura, C.C. J. Mol. Endocrinol. (2006) [Pubmed]
  28. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Reubi, J.C., Waser, B. Eur. J. Nucl. Med. Mol. Imaging (2003) [Pubmed]
  29. Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. Oeffner, F., Bornholdt, D., Ziegler, A., Hinney, A., Görg, T., Gerber, G., Goldschmidt, H.P., Siegfried, W., Wright, A., Hebebrand, J., Grzeschik, K.H. Acta diabetologica. (2000) [Pubmed]
  30. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Ryan, R.R., Taylor, J.E., Daniel, J.L., Cowan, A. Eur. J. Pharmacol. (1996) [Pubmed]
  31. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. Ryan, R.R., Katsuno, T., Mantey, S.A., Pradhan, T.K., Weber, H.C., Coy, D.H., Battey, J.F., Jensen, R.T. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  32. Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system. Wada, E., Way, J., Lebacq-Verheyden, A.M., Battey, J.F. J. Neurosci. (1990) [Pubmed]
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