Disease relevance of triallate

• Diallate and triallate were tested in the Salmonella/microsome assay over dose ranges of 0.59 to 118.0 micrograms/plate and 6.37 to 1273 micrograms/plate, respectively [1].
• In the mouse lymphoma L5178Y TK+/- assay, diallate was tested at concentrations ranging from 1 to 72 micrograms/ml, and triallate was tested at 0.5 to 60 micrograms/ml [1].

High impact information on triallate

• Microsomal hydroxylation of triallate: identification of a 2-chloroacrylate glutathione conjugate using heteronuclear multiple quantum coherence NMR spectroscopy [2].
• Both diallate and triallate gave positive results in S. typhimurium strains TA1535, TA98, and TA100 only in the presence of a rat-liver metabolic activation system [1].
• Both diallate and triallate gave negative results for mitotic gene conversion, mitotic crossing-over, and reverse mutation [1].
• DNA repair studies on diallate, triallate and sulfallate in human cell cultures [3].
• Two recessive gene inheritance for triallate resistance in Avena fatua L [4].

Chemical compound and disease context of triallate

• Three carbamates, diallate, triallate and vegadex, which contain a chloroallyl group similar to the vinyl group of dichlorvos are mutagenic in Streptomyes; triallate and vegadex are powerful mutagens also in Salmonella (strain TAI535); two other carbamates devoid of the chlorinated group are not mutagenic [5].

Biological context of triallate

• AIMS: To evaluate the relation between an indicator of cumulative exposure to triallate and selected measures of neurological function, including nerve conduction, the prevalence of certain neurological deficits as determined by a medical examination, and vibration perception threshold testing in workers at a pesticide manufacturing plant [6].
• The weight of evidence strongly suggests that triallate is not likely to exert mutagenic activity in vivo due to toxicokinetics and metabolic processes leading to detoxification [7].
• On the basis of IC50 values the cytotoxic effect was: dichlofluanid (IC50 = 10(-3.94) M) > tolylfluanid (IC50 = 10(-3.69) M) > endosulfan (IC50 = 10(-3.24) M) > triallate (IC50 = 10(-3.12) M) > simazine (IC50 = 10(-1.78) M) [8].

Anatomical context of triallate

• The high triallate group had lower mean sural nerve peak amplitude than the no/low triallate group (11.7 v 15.2 microV, p = 0.03) [6].

Associations of triallate with other chemical compounds

• In this study pesticides with different chemical structures (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) were examined for their potential cytotoxic effect on proliferative activity of cell cultures of mammalian origin [8].
• In vitro effect of pesticides (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) on proliferative activity of animal derived cell cultures [8].

Gene context of triallate

• Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens [9].

Analytical, diagnostic and therapeutic context of triallate

• Analysis of triallate residues in cereals and soil by gas chromatography with ion-trap detection [10].
• Commercial-grade preparations of two thiocarbamate herbicides, diallate and triallate, were evaluated for their mutagenic potential in a battery of short-term bioassays [1].
• A cross-sectional study of triallate exposure and neurological health among workers at a pesticide manufacturing and formulating facility [6].
• Plasma butyrylcholinesterase increased significantly 24 hr after treatment with triallate in a dose-dependent manner [9].

References