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Chemical Compound Review

triallate     N,N-dipropan-2-yl-1-(2,3,3- trichloroprop-2...

Synonyms: Triallat, Dipthal, Triamyl, Far-Go, Tri-allate, ...
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Disease relevance of triallate

  • Diallate and triallate were tested in the Salmonella/microsome assay over dose ranges of 0.59 to 118.0 micrograms/plate and 6.37 to 1273 micrograms/plate, respectively [1].
  • In the mouse lymphoma L5178Y TK+/- assay, diallate was tested at concentrations ranging from 1 to 72 micrograms/ml, and triallate was tested at 0.5 to 60 micrograms/ml [1].

High impact information on triallate


Chemical compound and disease context of triallate

  • Three carbamates, diallate, triallate and vegadex, which contain a chloroallyl group similar to the vinyl group of dichlorvos are mutagenic in Streptomyes; triallate and vegadex are powerful mutagens also in Salmonella (strain TAI535); two other carbamates devoid of the chlorinated group are not mutagenic [5].

Biological context of triallate

  • AIMS: To evaluate the relation between an indicator of cumulative exposure to triallate and selected measures of neurological function, including nerve conduction, the prevalence of certain neurological deficits as determined by a medical examination, and vibration perception threshold testing in workers at a pesticide manufacturing plant [6].
  • The weight of evidence strongly suggests that triallate is not likely to exert mutagenic activity in vivo due to toxicokinetics and metabolic processes leading to detoxification [7].
  • On the basis of IC50 values the cytotoxic effect was: dichlofluanid (IC50 = 10(-3.94) M) > tolylfluanid (IC50 = 10(-3.69) M) > endosulfan (IC50 = 10(-3.24) M) > triallate (IC50 = 10(-3.12) M) > simazine (IC50 = 10(-1.78) M) [8].

Anatomical context of triallate


Associations of triallate with other chemical compounds


Gene context of triallate


Analytical, diagnostic and therapeutic context of triallate


  1. Evaluation of diallate and triallate herbicides for genotoxic effects in a battery of in vitro and short-term in vivo tests. Sandhu, S.S., Waters, M.D., Mortelmans, K.E., Evans, E.L., Jotz, M.M., Mitchell, A.D., Kasica, V. Mutat. Res. (1984) [Pubmed]
  2. Microsomal hydroxylation of triallate: identification of a 2-chloroacrylate glutathione conjugate using heteronuclear multiple quantum coherence NMR spectroscopy. Hackett, A.G., Kotyk, J.J., Fujiwara, H., Logusch, E.W. Drug Metab. Dispos. (1991) [Pubmed]
  3. DNA repair studies on diallate, triallate and sulfallate in human cell cultures. Benigni, R., Dogliotti, E., Falcone, E., Calcagnile, A. Mutat. Res. (1982) [Pubmed]
  4. Two recessive gene inheritance for triallate resistance in Avena fatua L. Kern, A.J., Myers, T.M., Jasieniuk, M., Murray, B.G., Maxwell, B.D., Dyer, W.E. J. Hered. (2002) [Pubmed]
  5. Mutagenicity of dichlorvos and other structurally related pesticides in Salmonella and Streptomyces. Carere, A., Ortali, V.A., Cardamone, G., Morpurgo, G. Chem. Biol. Interact. (1978) [Pubmed]
  6. A cross-sectional study of triallate exposure and neurological health among workers at a pesticide manufacturing and formulating facility. Sathiakumar, N., Delzell, E., MacLennan, P.A., Anne, M., Rosenberg, N.L., Cheng, H., Myers, S.L. Occupational and environmental medicine. (2004) [Pubmed]
  7. A review of the genotoxicity of triallate. Healy, C.E., Kier, L.D., Broeckaert, F., Martens, M.A. International journal of toxicology. (2003) [Pubmed]
  8. In vitro effect of pesticides (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) on proliferative activity of animal derived cell cultures. Holovská, V., Pistl, J., Kovalkovicová, N. Acta. Biol. Hung. (2007) [Pubmed]
  9. Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens. Lapadula, D.M., Johannsen, F., Abou-Donia, M.B. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1990) [Pubmed]
  10. Analysis of triallate residues in cereals and soil by gas chromatography with ion-trap detection. Sanchez-Brunete, C., Salto, T., Garcia-Baudin, J.M., Tadeo, J.L. J. Chromatogr. (1991) [Pubmed]
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