The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

ANGIOTAN     (2S)-3-methyl-2-[pentanoyl- [[4-[2-(2H...

Synonyms: Kalpress, Valsarran, Valzaar, Varexan, valsartan, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of D00400


High impact information on D00400


Biological context of D00400


Associations of D00400 with other chemical compounds

  • METHODS AND RESULTS: Accordingly, atrial and ventricular myocardial electrophysiological properties were examined in adult rat (n = 13) and guinea pig (n = 9) myocardial preparations in the presence of the specific AT1 Ang II receptor antagonist, valsartan (CGP 48933; 0.5, 5, or 500 mumol/L) [10].

Gene context of D00400

  • PD completely blocked the chronic hypotensive response to the combination of Ang II and VAL to control levels before VAL administration [11].


  1. Fixed combination therapy of hypertension: focus on valsartan/hydrochlorothiazide combination (Diovan/HCT). Chrysant, S.G. Expert review of cardiovascular therapy. (2003) [Pubmed]
  2. The role of Valsartan, an Angiotensin II receptor antagonist, on portal and systemic hemodynamics and on renal function in liver cirrhosis. Fierbinteanu-Braticevici, C., Dragomir, P., Tribus, L., Negreanu, L., Bengus, A., Usvat, R., Andronescu, D. Journal of gastrointestinal and liver diseases : JGLD (2006) [Pubmed]
  3. Pharmacological profile of valsartan, a non-peptide angiotensin II type 1 receptor antagonist. 4th communication: improvement of heart failure of rats with myocardial infarction by valasartan. Hayashi, N., Fujimura, Y., Yamamoto, S., Kometani, M., Nakao, K. Arzneimittel-Forschung. (1997) [Pubmed]
  4. A new angiotensin-II- receptor blocker, CGP 48933: local tolerance and effect on intraocular pressure. A pilot study. Kaiser, H.J., Graf, T., Krejci, G., Mathis, G.A., Jauch, A., Flammer, J. European journal of ophthalmology. (1997) [Pubmed]
  5. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin1 receptors. Dubey, R.K., Jackson, E.K., Lüscher, T.F. J. Clin. Invest. (1995) [Pubmed]
  6. Bradykinin decreases plasminogen activator inhibitor-1 expression and facilitates matrix degradation in the renal tubulointerstitium under angiotensin-converting enzyme blockade. Okada, H., Watanabe, Y., Kikuta, T., Kobayashi, T., Kanno, Y., Sugaya, T., Suzuki, H. J. Am. Soc. Nephrol. (2004) [Pubmed]
  7. Bioequivalence study of a valsartan tablet and a capsule formulation after single dosing in healthy volunteers using a replicated crossover design. Séchaud, R., Graf, P., Bigler, H., Gruendl, E., Letzkus, M., Merz, M. International journal of clinical pharmacology and therapeutics. (2002) [Pubmed]
  8. Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos). Butler, D.G., Zandevakili, R., Oudit, G.Y. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (1998) [Pubmed]
  9. A comparison of valsartan and perindopril in the treatment of essential hypertension in the malaysian population. Bavanandan, S., Morad, Z., Ismail, O., Chandran, A., Thayaparan, T., Singaraveloo, M. Med. J. Malaysia (2005) [Pubmed]
  10. Myocardial electrophysiological properties in the presence of an AT1 angiotensin II receptor antagonist. Cox, M.H., O, S.J., de Gasparo, M., Mukherjee, R., Hewett, K.W., Spinale, F.G. Basic Res. Cardiol. (1997) [Pubmed]
  11. Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats. Carey, R.M., Howell, N.L., Jin, X.H., Siragy, H.M. Hypertension (2001) [Pubmed]
WikiGenes - Universities