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Gene Review

Bdkrb2  -  bradykinin receptor, beta 2

Mus musculus

Synonyms: B(2), B2, B2 bradykinin receptor, B2R, BK-2, ...
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Disease relevance of Bdkrb2


Psychiatry related information on Bdkrb2


High impact information on Bdkrb2


Chemical compound and disease context of Bdkrb2

  • The nociceptive response to intraplantar injection of bradykinin (10 nmol) and hyperalgesia induced by carrageenan (0.6 mg) were absent in Bk2r-/- mice, indicating that stimulation of B2 receptors is an essential step in the initiation of some nociceptive and inflammatory reactions [8].
  • The kinin B1 receptor antagonist [Leu8]des-Arg9-bradykinin or the B2 antagonist d-Arg[Hyp3,Thi5,D-Tic7, Oic8]bradykinin (HOE-140) was injected subcutaneously into STZ mice at 300 micrograms/kg body weight twice a day and 500 micrograms/kg per day, respectively [9].
  • The i.p.l. co-injection of tyrosine8-bradykinin (a B2 agonist, 3-15 nmol/paw) with formalin (0.01 or 0.5%) potentiated the pain response and paw oedema in BCG and saline-pre-treated animals to the same extent (P < 0.01) [10].
  • Thus, in mice, kinins acting via B2 receptors do not participate in (1) maintenance of normal basal blood pressure, (2) establishment and maintenance of hypertension induced by DOCA-salt or aortic coarctation, and (3) chronic antihypertensive and cardiac antihypertrophic effects of ACEi in DOCA-salt and aortic coarctation hypertension [11].
  • 5. These results suggest that BK1 along with BK2 receptors are located on capsaicin-sensitive fibres, where they may modulate the degree of neurogenic inflammation [12].

Biological context of Bdkrb2


Anatomical context of Bdkrb2

  • Evans blue extravasation in brain tissue at 4 h after CHT was abolished by Anatibant Ms. It appeared that Anatibant Ms penetrated into the brain in sufficient amounts, particularly after disruption of the blood-brain barrier, to account for its B2R-mediated neuro- and vascular protective effects [2].
  • The results suggest that the mouse B2 BK receptor couples to phospholipase C in CHO cells and that its activation results in biphasic [Ca2+]i increases, by mobilization of intracellular Ca2+ and store-depletion-mediated Ca2+ influx, the latter of which is tyrosine phosphorylation dependent [14].
  • EP24.15 was also co-immunoprecipitated with AT1 and B2 in rat kidney brush border membranes (BBM) and basolateral membranes (BLM) [15].
  • During normal salt intake, renal interstitial fluid NO and cGMP levels in B2-null mice were not different from those of wild-type mice [16].
  • [3H]bradykinin receptor-binding, receptor-recycling, and receptor-internalization of the B2 bradykinin receptor in the murine osteoblast-like cell line MC3T3-E1 [17].

Associations of Bdkrb2 with chemical compounds


Regulatory relationships of Bdkrb2


Other interactions of Bdkrb2

  • In WT and TK-/- mice, both B2 and B1 mRNA levels increased several fold during IR, and even more during IPC+IR [3].
  • Blockade of the AT1 receptor enhances the production of NO via the AT2 receptor in both wild-type and B2-null mice [16].
  • The transcriptional effects of TAp73 on AQP-2 and B2R were independent of p53 [19].
  • The B2 receptor is constitutively expressed, and its targeted disruption leads to salt-sensitive hypertension and altered nociception [18].
  • BK-induced contractions were prevented by mergetpa (a carboxypeptidase M inhibitor) (10 microM) and by a the B receptor antagonist, AcLys[DbetaNal7,Ile8]desArg9BK (R 715) (0.88 microM), while not being influenced by the B2 receptor antagonist HOE 140 (0.38 microM) [25].

Analytical, diagnostic and therapeutic context of Bdkrb2

  • METHODS: We investigated the effect and mechanisms of tissue kallikrein using hypertrophic animal models of rats as well as mice deficient in kinin B1 or B2 receptor after aortic constriction (AC) [1].
  • Our results indicate that during ingestion of a low-salt diet, production of NO is mediated mainly via the AT2-B2 receptor cascade [16].
  • Using quantitative RT-PCR analysis of B1 and B2 mRNAs expression, we described for the first time a correlation between the kallikrein-kinin system (KKS) and severe obesity in mice [26].
  • In a first step to better understand how BK and its receptors could be involved in such a large variety of biological effects, we used microarray analysis to identify, under physiological conditions, the global renal gene expression profile in mice lacking either the kinin B1 or B2 receptor [27].
  • In two separate groups of wild type hearts, B1 and B2 receptors were blocked with 3 nM of (des-Arg9, Leu8)-bradykinin and 10 nM of Hoe 140, respectively, (started 15 min before ischemia and stopped before the reperfusion) [28].


  1. Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. Li, H.J., Yin, H., Yao, Y.Y., Shen, B., Bader, M., Chao, L., Chao, J. Cardiovasc. Res. (2007) [Pubmed]
  2. Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier. Ongali, B., Hellal, F., Rodi, D., Plotkine, M., Marchand-Verrecchia, C., Pruneau, D., Couture, R. J. Neurotrauma (2006) [Pubmed]
  3. Role of tissue kallikrein in the cardioprotective effects of ischemic and pharmacological preconditioning in myocardial ischemia. Griol-Charhbili, V., Messadi-Laribi, E., Bascands, J.L., Heudes, D., Meneton, P., Giudicelli, J.F., Alhenc-Gelas, F., Richer, C. FASEB J. (2005) [Pubmed]
  4. Central angiotensin II controls alcohol consumption via its AT1 receptor. Maul, B., Krause, W., Pankow, K., Becker, M., Gembardt, F., Alenina, N., Walther, T., Bader, M., Siems, W.E. FASEB J. (2005) [Pubmed]
  5. Transient and locally restricted expression of laminin A chain mRNA by developing epithelial cells during kidney organogenesis. Ekblom, M., Klein, G., Mugrauer, G., Fecker, L., Deutzmann, R., Timpl, R., Ekblom, P. Cell (1990) [Pubmed]
  6. Regulation of RNA polymerase III transcription in response to F9 embryonal carcinoma stem cell differentiation. White, R.J., Stott, D., Rigby, P.W. Cell (1989) [Pubmed]
  7. Regulation of prostaglandin synthesis mediated by thrombin and B2 bradykinin receptors in a fibrosarcoma cell line. Becherer, P.R., Mertz, L.F., Baenziger, N.L. Cell (1982) [Pubmed]
  8. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice. Rupniak, N.M., Boyce, S., Webb, J.K., Williams, A.R., Carlson, E.J., Hill, R.G., Borkowski, J.A., Hess, J.F. Pain (1997) [Pubmed]
  9. Effects of B1 and B2 kinin receptor antagonists in diabetic mice. Zuccollo, A., Navarro, M., Catanzaro, O. Can. J. Physiol. Pharmacol. (1996) [Pubmed]
  10. Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice. de Campos, R.O., Henriques, M.G., Calixto, J.B. Neuropeptides (1998) [Pubmed]
  11. Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice: do kinin B2 receptors play a role? Rhaleb, N.E., Peng, H., Alfie, M.E., Shesely, E.G., Carretero, O.A. Hypertension (1999) [Pubmed]
  12. A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice. Mantione, C.R., Rodriguez, R. Br. J. Pharmacol. (1990) [Pubmed]
  13. Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient mice. Trabold, F., Pons, S., Hagege, A.A., Bloch-Faure, M., Alhenc-Gelas, F., Giudicelli, J.F., Richer-Giudicelli, C., Meneton, P. Hypertension (2002) [Pubmed]
  14. Ca2+ release and Ca2+ influx in Chinese hamster ovary cells expressing the cloned mouse B2 bradykinin receptor: tyrosine kinase inhibitor-sensitive and- insensitive processes. Taketo, M., Yokoyama, S., Kimura, Y., Higashida, H. Biochim. Biophys. Acta (1997) [Pubmed]
  15. EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. Shivakumar, B.R., Wang, Z., Hammond, T.G., Harris, R.C. Cell Biochem. Funct. (2005) [Pubmed]
  16. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Abadir, P.M., Carey, R.M., Siragy, H.M. Hypertension (2003) [Pubmed]
  17. [3H]bradykinin receptor-binding, receptor-recycling, and receptor-internalization of the B2 bradykinin receptor in the murine osteoblast-like cell line MC3T3-E1. Windischhofer, W., Leis, H.J. J. Bone Miner. Res. (1997) [Pubmed]
  18. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva, J.A., Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C., Calixto, J.B., Lewin, G.R., Bader, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. Saifudeen, Z., Diavolitsis, V., Stefkova, J., Dipp, S., Fan, H., El-Dahr, S.S. J. Biol. Chem. (2005) [Pubmed]
  20. Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor. Cervenka, L., Vanecková, I., Malý, J., Horácek, V., El-Dahr, S.S. J. Hypertens. (2003) [Pubmed]
  21. Bradykinin B2 receptor activates extracellular signal-regulated protein kinase in mIMCD-3 cells via epidermal growth factor receptor transactivation. Mukhin, Y.V., Garnovsky, E.A., Ullian, M.E., Garnovskaya, M.N. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  22. Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Duka, I., Duka, A., Kintsurashvili, E., Johns, C., Gavras, I., Gavras, H. Hypertension (2003) [Pubmed]
  23. Glucocorticoids suppress transcriptional up-regulation of bradykinin receptors in a murine in vitro model of chronic airway inflammation. Zhang, Y., Adner, M., Cardell, L.O. Clin. Exp. Allergy (2005) [Pubmed]
  24. Bradykinin down-regulates LPS-induced eosinophil accumulation in the pleural cavity of mice through type 2-kinin receptor activation: a role for prostaglandins. Silva, A.R., Larangeira, A.P., Pacheco, P., Calixto, J.B., Henriques, M.G., Bozza, P.T., Castro-Faria-Neto, H.C. Br. J. Pharmacol. (1999) [Pubmed]
  25. Effects of kinins on isolated stomachs of control and transgenic knockout B2 receptor mice. Nsa Allogho, S., Gobeil, F., Perron, S.I., Hess, J.F., Regoli, D. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
  26. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Abe, K.C., da Silva Mori, M.A., Pesquero, J.B. Regul. Pept. (2007) [Pubmed]
  27. Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes. Bachvarov, D., Bachvarova, M., Koumangaye, R., Klein, J., Pesquero, J.B., Neau, E., Bader, M., Schanstra, J.P., Bascands, J.L. Biol. Chem. (2006) [Pubmed]
  28. Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice. Lagneux, C., Bader, M., Pesquero, J.B., Demenge, P., Ribuot, C. Int. Immunopharmacol. (2002) [Pubmed]
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