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Chemical Compound Review

AC1O3RH3     octadecylsilicon

Synonyms: 442291_ALDRICH, 18623-11-5, Octadecylsilane, EINECS 242-453-9, U - 2,3-Dichlorophenol
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High impact information on octadecylsilicon

  • Synchrotron x-ray reflectivity measurements of the interface between water and methyl-terminated octadecylsilane monolayers with stable contact angle >100 degrees conclusively show a depletion layer, whether or not the water is degassed [1].
  • A 5-cm precolumn and a 35-cm analytical column, both fused-silica capillaries with an i.d. of 100 microm and packed with 3-microm octadecylsilane-bonded material, are coupled in series to a sheathless ES emitter [2].
  • Comparative studies involving the EOF within such sol-gel ODS coated and uncoated capillaries were performed using acetonitrile and methanol as the organic modifiers in the mobile phase [3].
  • The conditioned medium was acidified to dissociate the binding protein, and OLI was purified by five steps of octadecylsilane (ODS) column chromatography [4].
  • Fused-silica capillaries with inner diameters of 33 microns and lengths of 25-50 cm are slurry-packed with 1.0-micron nonporous octadecylsilane-modified (C18) silica spheres [5].

Biological context of octadecylsilicon


Anatomical context of octadecylsilicon

  • In this work, fused-silica capillaries with inner diameters of 30 microns are slurry packed with 1.5 microns nonporous octadecylsilane-modified silica particles [8].
  • When cells were cultured on these materials in serum-containing medium, formation of FN receptor-rich focal adhesions and actin stress fibers were more evident on the hydrophilic surfaces (GLASS and APS) compared to the hydrophobic ones (PL, ODS, and SI) [9].
  • PURPOSE: The present study evaluates immobilized artificial membrane (IAM) chromatography for predicting drug permeability across the blood-brain barrier (BBB) and outlines the potential and limitations of IAMs as a predictive tool by comparison with conventional methods based on octanol/water partitioning and octadecylsilane (ODS)-HPLC [10].
  • Immunofluorescence microscopy revealed increased stress formation and fibronectin (FN) receptor-rich focal adhesions for fibroblasts attached on more hydrophilic surfaces (glass and APS) in comparison to the relatively hydrophobic materials (ODS and SI) [6].

Associations of octadecylsilicon with other chemical compounds


Gene context of octadecylsilicon

  • Extraction of cholecystokinin peptides from biological fluids using octadecylsilane-packed cartridges [15].
  • The method comprises an isolation step of sulfated steroids by means of octadecylsilane-bonded (C18) reverse phase column chromatography, a solvolysis step for desulfation of sulfated steroids, and a C18 TLC step for measurement on a photodensitometer [16].
  • The PRP-1 column with a trifluoroacetic acid-acetonitrile solvent system produced a better and more reproducible separation of TRH catabolic products than the ODS column with the acetic acid-acetonitrile solvent system [17].
  • This was done using a commercial Chromolith column with an octadecylsilane stationary phase and a tryptic digest of cytochrome c. Columns (100 mm x 4.6 mm) were operated at mobile phase velocities ranging from 1 ml/min (2.0 mm/s) to 10 ml/min (25 mm/s) [18].
  • The organic layer was evaporated to dryness, reconstituted with mobile phase, and the analytes were separated and quantified by LC on an octadecylsilane column with acetonitrile-0.1 mol dm-3 phosphate buffer (pH3) as mobile phase and UV detection at 280 nm [19].

Analytical, diagnostic and therapeutic context of octadecylsilicon

  • Anthocyanins were measured in plasma and urine by combining an octadecylsilane solid-phase extraction for sample preparation and an HPLC system with diode array for anthocyanin separation and detection [20].
  • The eluates are assayed for the individual catecholamines by "high-performance" liquid chromatography with an octadecylsilane reversed-phase column and 10 mmol/L perchloric acid-acetonitrile (99/1) as the mobile phase [21].
  • Structure-function relationships in high-density docosylsilane bonded stationary phases by Raman spectroscopy and comparison to octadecylsilane bonded stationary phases [22].
  • Combined supercritical fluid extraction/solid-phase extraction with octadecylsilane cartridges as a sample preparation technique for the ultratrace analysis of a drug metabolite in plasma [13].
  • A 25-cm separation channel with spiral geometry for open-channel electrochromatography was chemically modified with octadecylsilane and coupled to a 1.2-cm straight separation channel for capillary electrophoresis [23].


  1. How water meets a hydrophobic surface. Poynor, A., Hong, L., Robinson, I.K., Granick, S., Zhang, Z., Fenter, P.A. Phys. Rev. Lett. (2006) [Pubmed]
  2. Capillary liquid chromatography/electrospray mass spectrometry for analysis of steroid sulfates in biological samples. Liu, S., Griffiths, W.J., Sjövall, J. Anal. Chem. (2003) [Pubmed]
  3. Sol-gel open tubular ODS columns with reversed electroosmotic flow for capillary electrochromatography. Hayes, J.D., Malik, A. Anal. Chem. (2001) [Pubmed]
  4. Identification of endogenous ouabain in culture supernatant of PC12 cells. Komiyama, Y., Nishimura, N., Munakata, M., Mori, T., Okuda, K., Nishino, N., Hirose, S., Kosaka, C., Masuda, M., Takahashi, H. J. Hypertens. (2001) [Pubmed]
  5. Ultrahigh-pressure reversed-phase capillary liquid chromatography: isocratic and gradient elution using columns packed with 1.0-micron particles. MacNair, J.E., Patel, K.D., Jorgenson, J.W. Anal. Chem. (1999) [Pubmed]
  6. Studies on cell-biomaterial interaction: role of tyrosine phosphorylation during fibroblast spreading on surfaces varying in wettability. Groth, T., Altankov, G. Biomaterials (1996) [Pubmed]
  7. Identification of a decarboxylation product of retinoic acid. Rockley, N.L., Halley, B.A., Nelson, E.C. Biochim. Biophys. Acta (1980) [Pubmed]
  8. Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. MacNair, J.E., Lewis, K.C., Jorgenson, J.W. Anal. Chem. (1997) [Pubmed]
  9. Studies on the biocompatibility of materials: fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability. Altankov, G., Grinnell, F., Groth, T. J. Biomed. Mater. Res. (1996) [Pubmed]
  10. Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier. Reichel, A., Begley, D.J. Pharm. Res. (1998) [Pubmed]
  11. Ion-pair high-pressure liquid chromatography of cis-trans isomers of retinoic acid in tissues of vitamin A-sufficient rats. Sundaresan, P.R., Bhat, P.V. J. Lipid Res. (1982) [Pubmed]
  12. Preparation and evaluation of slurry-packed liquid chromatography microcolumns with inner diameters from 12 to 33 microns. Hsieh, S., Jorgenson, J.W. Anal. Chem. (1996) [Pubmed]
  13. Combined supercritical fluid extraction/solid-phase extraction with octadecylsilane cartridges as a sample preparation technique for the ultratrace analysis of a drug metabolite in plasma. Liu, H., Cooper, L.M., Raynie, D.E., Pinkston, J.D., Wehmeyer, K.R. Anal. Chem. (1992) [Pubmed]
  14. High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans. Lucas, D., Berthou, F., Girre, C., Poitrenaud, F., Ménez, J.F. J. Chromatogr. (1993) [Pubmed]
  15. Extraction of cholecystokinin peptides from biological fluids using octadecylsilane-packed cartridges. Miller, L.J., Bouska, J.B., Go, V.L. J. Chromatogr. (1986) [Pubmed]
  16. Simplified method of determination of serum cholesterol sulfate by reverse phase thin-layer chromatography. Serizawa, S., Nagai, T., Sato, Y. J. Invest. Dermatol. (1987) [Pubmed]
  17. Rapid separation of tritiated thyrotropin-releasing hormone and its catabolic products from mouse and human central nervous system tissues by high-performance liquid chromatography with radioactive flow detection. Turner, J.G., Schwartz, T.M., Brooks, B.R. J. Chromatogr. (1989) [Pubmed]
  18. Potential of silica monolithic columns in peptide separations. Xiong, L., Zhang, R., Regnier, F.E. Journal of chromatography. A. (2004) [Pubmed]
  19. Simultaneous determination of rufloxacin and theophylline by high-performance liquid chromatography in human plasma. Carlucci, G., Mazzeo, P., Palumbo, G. The Analyst. (1995) [Pubmed]
  20. Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Cao, G., Muccitelli, H.U., Sánchez-Moreno, C., Prior, R.L. Am. J. Clin. Nutr. (2001) [Pubmed]
  21. Differential assay for urinary catecholamines by use of liquid chromatography with fluorescence detection. Jackman, G.P. Clin. Chem. (1981) [Pubmed]
  22. Structure-function relationships in high-density docosylsilane bonded stationary phases by Raman spectroscopy and comparison to octadecylsilane bonded stationary phases. Liao, Z., Orendorff, C.J., Sander, L.C., Pemberton, J.E. Anal. Chem. (2006) [Pubmed]
  23. Two-dimensional electrochromatography/capillary electrophoresis on a microchip. Gottschlich, N., Jacobson, S.C., Culbertson, C.T., Ramsey, J.M. Anal. Chem. (2001) [Pubmed]
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