The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEBI:35291     (2E,4E,6E,8E)-3,7-dimethyl-9- (2,6,6...

Synonyms: AC1O4WBN, KB-61991, ZINC12358651, A820291, 3cwk, ...
This record was replaced with 444795.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Retin-A

  • In the trachea, hyperplasia of basal epithelial cells was observed by Day 4 (T4) following the withdrawal of retinoic acid from retinoate-cycled, stringently deficient rats [1].
  • The cytotoxicity was determined using an MTT assay with HCT116 colon cancer cells, and the IC(50) of N-acylated retinamide derivative 4A and O-acylated retinoate derivative 5B was 1.67 microM and 0.65 microM, respectively, which are about five and 13-fold better than that of 4-HPR (8.21 microM), a prototype N-acylated derivative [2].

High impact information on Retin-A


Biological context of Retin-A


Anatomical context of Retin-A


Associations of Retin-A with other chemical compounds


Gene context of Retin-A

  • In contrast, the O-acylated retinoate derivatives (1B-5B) activated all three RAR isotypes without specificity to an extent similar to ATRA [2].

Analytical, diagnostic and therapeutic context of Retin-A

  • Radioimmunoassay revealed that the amount (pmol of epitope/mg of total glycosaminoglycan) of (342)FFGVG epitope released from cartilage remained constant over a 5-day culture period and was not increased by IL-1alpha or retinoate [14].


  1. Morphologic alterations in the trachea and the salivary gland following the induction of rapid synchronous vitamin A deficiency in rats. Anzano, M.A., Olson, J.A., Lamb, A.J. Am. J. Pathol. (1980) [Pubmed]
  2. Synthesis and biological activity of novel retinamide and retinoate derivatives. Um, S.J., Kwon, Y.J., Han, H.S., Park, S.H., Park, M.S., Rho, Y.S., Sin, H.S. Chem. Pharm. Bull. (2004) [Pubmed]
  3. Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis. Matthias, A., Ohlson, K.B., Fredriksson, J.M., Jacobsson, A., Nedergaard, J., Cannon, B. J. Biol. Chem. (2000) [Pubmed]
  4. Retinoic acid acylation (retinoylation) of a nuclear protein in the human acute myeloid leukemia cell line HL60. Takahashi, N., Breitman, T.R. J. Biol. Chem. (1989) [Pubmed]
  5. Retinoic acid analogues. Synthesis and potential as cancer chemopreventive agents. Dawson, M.I., Hobbs, P.D., Kuhlmann, K., Fung, V.A., Helmes, C.T., Chao, W.R. J. Med. Chem. (1980) [Pubmed]
  6. Impaired blood clearance of bacteria and phagocytic activity in vitamin A-deficient rats. Ongsakul, M., Sirisinha, S., Lamb, A.J. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  7. Expression and activity of ADAMTS-5 in synovium. Vankemmelbeke, M.N., Holen, I., Wilson, A.G., Ilic, M.Z., Handley, C.J., Kelner, G.S., Clark, M., Liu, C., Maki, R.A., Burnett, D., Buttle, D.J. Eur. J. Biochem. (2001) [Pubmed]
  8. Effects of retinoids on plating efficiency, sister-chromatid exchange (SCE) and mitomycin-C-induced SCE in cultured Chinese hamster cells. Sirianni, S.R., Chen, H.H., Huang, C.C. Mutat. Res. (1981) [Pubmed]
  9. The pharmacology of a novel topical retinoid, BMY 30123: comparison with tretinoin. Tramposch, K.M., Nair, X., Gendimenico, G.J., Tetrault, G.B., Chen, S., Kiss, I., Whiting, G., Bonney, R.J. J. Pharm. Pharmacol. (1992) [Pubmed]
  10. Metabolism of all-trans-retinol and all-trans-retinoic acid in rabbit tracheal epithelial cells in culture. Bhat, P.V., Jetten, A.M. Biochim. Biophys. Acta (1987) [Pubmed]
  11. New retinoids inhibiting the growth of human acute promyelocytic leukemia cell line HL-60 without inducing differentiation. Suzuki, T., Kawamura, S., Matsui, M., Murayama, A. J. Nutr. Sci. Vitaminol. (1993) [Pubmed]
  12. Different susceptibility of lung cell lines to inhibitors of tumor promotion and inducers of differentiation. Zhu, H.G., Tayeh, I., Israel, L., Castagna, M. J. Biol. Regul. Homeost. Agents (1991) [Pubmed]
  13. Modulation of secreted plasminogen activator activity of human renal carcinoma cells by dimethylsulfoxide, butyrate and retinoate. Nelson, N.F., Cieplak, W., Dacus, S.C., Prager, M.D. Cancer Lett. (1987) [Pubmed]
  14. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants. Fosang, A.J., Last, K., Stanton, H., Weeks, D.B., Campbell, I.K., Hardingham, T.E., Hembry, R.M. J. Biol. Chem. (2000) [Pubmed]
WikiGenes - Universities