Disease relevance of Trifrina

• No extrar haematological G 3-4 toxicities were observed [1].
• DNBP (7.5 mg/kg), DNOC (15 mg/kg), and DNP (30 mg/kg) caused 1, 5, and 0 deaths, respectively, as well as a decreased body weights during the treatment [2].
• Dinitro and mononitrobenzo(ghi)perylenes and mononitrocoronene are highly mutagenic in the Ames Salmonella assay [3].

Psychiatry related information on Trifrina

• The products were the rare, vicinal dinitro derivatives formed in excellent yields and short reaction times [4].

High impact information on Trifrina

• Two new oligothiophenes, the dinitro compound 3',4'-dibutyl-5,5' '-dinitro-2,2':5',2' '-terthiophene (1) and the quinodimethane 3',4'-dibutyl-5,5' '-bis(dicyanomethylene)-5,5' '-dihydro-2,2':5',2' '-terthiophene (2), have been synthesized and studied with electrochemistry, UV-vis-NIR-IR spectroscopy, ESR, and X-ray crystallography [5].
• 4,6-Dinitro-o-cresol uncouples oxidative phosphorylation and induces membrane permeability transition in rat liver mitochondria [6].
• The pH of the mobile phase buffers, the buffer composition, the number and position of the dinitro groups on the phenyl ring substituent, the degree of substitution, and the bonding strategy all greatly affect the performance of the CSPs [7].
• The molar absorptivity value of DNOC sorbed to K-SWy-2 smectite was 1.43 x 10(7) cm2/mol in good agreement with literature values for nitroaromatics (average value of 1.72 x 10(7) +/- 0.3 cm2/mol) [8].
• FTIR spectra of DNOC and DINOSEB sorbed to a K-SWy-2 smectite were studied quantitatively using a modified form of Beers law [8].

Biological context of Trifrina

• Although examinations on D3 revealed no treatment-related alterations, DNBP and DNOC resulted in reduced sperm motility and increased incidence of tailless sperm in the cauda epididymis on D14 [2].
• 3-Methyl-4-nitrophenol at the applied dosage did not result in teratogenic or prenatal chromosome damage in contrast to the damaging effect of 4,6-dinitro-o-cresol which was previously reported [9].
• Induction of biotransformation in the liver of Eel (Anguilla anguilla L.) by sublethal exposure to dinitro-o-cresol: an ultrastructural and biochemical study [10].
• Human glutathione reductase was not appreciably inhibited by any of the compounds, except for one dinitro organotellurium compound that caused inhibition with an IC50 of 0.5 microM and an over 20-fold selectivity compared to thioredoxin reductase [11].
• Two pesticides, fenarimol and DNOC, were capable of inducing DNA damage because they significantly increased the DNA unwinding rate [12].

Anatomical context of Trifrina

• The mutagenic effect of a dinitro-o-cresol-containing pesticide on mice germ cells [13].
• We found that three newly synthesized dinitro- or nitroimidazole derivatives caused oxidative damage of erythrocytes in aerobic conditions [14].
• Pathogenetic transition in the morphology of abnormal sperm in the testes and the caput, corpus, and cauda epididymides of male rats after treatment with 4,6-dinitro-o-cresol [15].
• Immunological cross-reactivity of anti-sera raised with fluoro dinitro benzene tagged normal human leukocytes against human leukaemic cells [16].
• Five pesticides [amitraz, cyanazine, cyhexatin, dinitro-o-cresol (DNOC), and fenarimol] were tested as pure active ingredients for in vivo induction of DNA strand breaks on rat hepatocytes after intraperitoneal (ip) treatment [12].

Associations of Trifrina with other chemical compounds

• Effects of dinoseb, 4,6-dinitro-o-cresol, and 2,4-dinitrophenol on rat Sertoli-germ cell co-cultures [17].
• The seven tyrosine residues in ovine prolactin have been modified, in separate experiments, with tetranitromethane and iodine at 0 degrees C. Both the nitration and iodination studies indicate Tyr-44 to be the most reactive; this residue was converted almost completely to the dinitro and diiodo derivative under the reaction conditions employed [18].

Analytical, diagnostic and therapeutic context of Trifrina

• The FTIR-derived sorption isotherm of DNOC sorbed to K-SWy-2 was in good agreement with the isotherm derived from HPLC measurements [8].
• The Spirotox was less sensitive than these other bioassays for the majority of these compounds, with an exception found for the dinitro derivatives [19].

References