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Chemical Compound Review

STYRENE     ethenylbenzene

Synonyms: Annamene, Cinnamol, Polysorb, Styropol, CARINE, ...
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Disease relevance of styrene


High impact information on styrene

  • Styrene (CAS No. 100-42-5) is an important industrial chemical for which positive results have been reported in in vitro and in vivo genotoxicity assays [3].
  • The knots studied: Tayside, Roeder, Melzer (modified Roeder), Cross square, and Blood knots were tied with the following materials: silk, polyamide, Dacron, polydioxanone (PDS), and lactomer (Polysorb) [4].
  • The nipples were further stabilized with metal and absorbable (Polysorb) staples and Marlex collars [5].
  • Experience with Lactomer absorbable surgical staples (Auto Suture Poly CS 57 disposable surgical stapler) in 62 cesarean sections was compared with an equal number of operations performed with standard techniques [6].
  • Bundles of tibia tendon from 19 week-old turkeys were deep frozen, freeze dried and embedded in styrol methacrylate or Epon [7].

Biological context of styrene


Anatomical context of styrene

  • CONCLUSIONS: The clinical results clearly demonstrated that the application of absorbable lactomer staples for closure of the transected margin of the pancreas is a safe alternative to the standard closure technique [10].
  • Cytoenzymochemical investigations were performed on the leukocytes and platelets from 2,782 workers occupationally exposed to benzene, vinyl chloride or carbon disulphide, in view of detecting the eventual occurrence of cytologic metabolic disorders induced by these chemical substances [11].
  • Except for Monocryl, all sutures, especially Polysorb and Vicryl, lost tensile strength much faster in bile, jejunal and pancreatic juices than in the corresponding buffers [12].

Associations of styrene with other chemical compounds

  • RESULTS: Polysorb had the highest linear tensile strength but also the fastest loss of function following tissue implantation, whereas Vicryl showed the slowest loss of function [13].
  • Howiinol A (GHM-10) is a kind of phenylethylene pyrone compounds isolated from Goniothalamus howii [14].
  • These particles were first swollen by a low molecular mass organic agent (i.e. dibutylphthalate, DBP) and then by a monomer mixture including styrene (S), 4-vinylphenyl boronic acid (VPBA) and divinylbenzene (DVB) [15].

Analytical, diagnostic and therapeutic context of styrene

  • Using scanning electron microscopy, the degradation characteristics of two absorbable ligating clips, Absolok (polydioxanone) and Lactomer (poly-L-lactide-co-30%-glycolide) have been studied under in vivo and in vitro conditions [16].
  • The locking mechanism strengths of the absorbable Absolok and Lactomer ligating clips and the absorbable Lactomer staple have been determined following implantation in an animal model [17].
  • The incidence of granulations at the vaginal vault at six weeks was significantly reduced (p = 0.001) and return to activity (p = 0.02) and work (p = 0.01) were also significantly reduced for the patients who had a hysterectomy performed using Polysorb staples [18].
  • CONCLUSION: Based on the overall bursting pressure and failure mode, #2 braided lactomer loop suture placed in a continuous pattern should provide sufficient security for closure of the equine linea alba during recovery and the immediate postoperative period [19].


  1. A study of tobacco carcinogenesis. XLVII. Bioassays of vinylpyridines for genotoxicity and for tumorigenicity in A/J mice. Brunnemann, K.D., Rivenson, A., Cheng, S.C., Saa, V., Hoffmann, D. Cancer Lett. (1992) [Pubmed]
  2. Effects of bacterial infection on absorbable vascular ligating clips. Chegini, N., Hay, D.L., von Fraunhofer, J.A., Masterson, B.J. The Journal of reproductive medicine. (1988) [Pubmed]
  3. Review of the genotoxicity of styrene in humans. Henderson, L.M., Speit, G. Mutat. Res. (2005) [Pubmed]
  4. Comparative study of the holding strength of slipknots using absorbable and nonabsorbable ligature materials. Shimi, S.M., Lirici, M., Vander Velpen, G., Cuschieri, A. Surgical endoscopy. (1994) [Pubmed]
  5. Study of antireflux nipple valves of Kock ileal urinary reservoir. Experimental investigation in dogs. Boyd, S.D., Skinner, D.G., Lieskovsky, G., Kawachi, M.H., Ahlering, T.E. Urology (1991) [Pubmed]
  6. Evaluation of surgical staples in cesarean section. Burkett, G., Jensen, L.P., Lai, A., O'Sullivan, M.J., Yasin, S., Beydoun, S., McLeod, A.G. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  7. Electron microscopic microprobe analysis of mineralized collagen fibrils and extracollagenous regions in turkey leg tendon. Höhling, H.J., Barckhaus, R.H., Krefting, E.R., Schreiber, J. Cell Tissue Res. (1976) [Pubmed]
  8. The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy. Trosko, J.E. Biomed. Pharmacother. (2005) [Pubmed]
  9. Aspects of bone healing and bone substitute incorporation. An experimental study in rabbit skull bone defects. Isaksson, S. Swedish dental journal. Supplement. (1992) [Pubmed]
  10. Safe closure technique for distal pancreatic resection. Farkas, G., Leindler, L., Farkas, G. Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie. (2005) [Pubmed]
  11. The value of some cytoenzymochemical investigations of the leukocytes and platelets in estimating the effects of occupational exposure to benzene, vinyl chloride and carbon disulphide. Micu, D., Mihăilescu, E., Vilău, C., Târpa, A., Chircu, V., Zgoanţă, C. Médecine interne. (1985) [Pubmed]
  12. Biodegradation of absorbable sutures in body fluids and pH buffers. Freudenberg, S., Rewerk, S., Kaess, M., Weiss, C., Dorn-Beinecke, A., Post, S. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (2004) [Pubmed]
  13. Physical, biological and handling characteristics of surgical suture material: a comparison of four different multifilament absorbable sutures. Debus, E.S., Geiger, D., Sailer, M., Ederer, J., Thiede, A. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1997) [Pubmed]
  14. Anticancer effect of Howiinol A and its mechanism of action. Xu, C.X., He, J.H. Journal of Asian natural products research. (1999) [Pubmed]
  15. Nucleotide adsorption-desorption behaviour of boronic acid functionalized uniform-porous particles. Senel, S., Camli, S.T., Tuncel, M., Tuncel, A. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
  16. A comparative scanning electron microscopic study on degradation of absorbable ligating clips in vivo and in vitro. Chegini, N., Hay, D.L., von Fraunhofer, J.A., Masterson, B.J. J. Biomed. Mater. Res. (1988) [Pubmed]
  17. Locking mechanism strength of absorbable ligating devices. Hay, D.L., von Fraunhofer, J.A., Chegini, N., Masterson, B.J. J. Biomed. Mater. Res. (1988) [Pubmed]
  18. A prospective comparison of abdominal hysterectomy using absorbable staples. Beresford, J.M., Moher, D. Surgery, gynecology & obstetrics. (1993) [Pubmed]
  19. An in vitro comparison of two suture intervals using braided absorbable loop suture in the equine linea alba. Hassan, K.A., Galuppo, L.D., van Hoogmoed, L.M. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2006) [Pubmed]
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