Disease relevance of gamma-Vinylpyridine

• On surfaces modified with N-hexylated poly(4-vinylpyridine), the numbers of viable cells of another Gram-positive bacterium, Staphylococcus epidermidis, as well as of the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli, dropped more than 100-fold compared with the original amino glass [1].
• 4-Vinylpyridine-induced dermatitis in a laboratory worker [2].

High impact information on gamma-Vinylpyridine

• This Account describes the ability of amphiphilic polymers (e.g., EO/PO/EO block copolymers) and polycations [e.g., quaternized poly(4-vinylpyridine)] to accelerate translocation from the inside leaflet to the outside leaflet ("flip-flop") within vesicle bilayer membranes [3].
• A stable subunit of Maackia amurensis leukoagglutinin (MMAL) was prepared by the selective reduction of disulfide bridges between the subunits followed by alkylation with 4-vinylpyridine [4].
• These results show that 4-vinylpyridine is an excellent reagent for the analysis of cysteinyl-containing peptides and support our analyses of the roles of cysteinyl residues in the gamma subunit in ATP synthesis and hydrolysis [5].
• Lipophilin was reduced and alkylated with 4-vinylpyridine at 10 of its cysteinyl residues [6].
• Nanotubes of poly(4-vinylpyridine) (PVP) and poly(acrylic acid) (PAA) were fabricated by hydrogen bonding based on layer-by-layer (LbL) assembly [7].

Biological context of gamma-Vinylpyridine

• Enhanced collective electron transport by CdSe quantum dots confined in the poly(4-vinylpyridine) nanodomains of a poly(styrene-b-4-vinylpyridine) diblock copolymer thin film [8].

Anatomical context of gamma-Vinylpyridine

• Multilayer assembly of calf thymus DNA and poly(4-vinylpyridine) derivative bearing [Os(bpy)(2)Cl](2+): redox behavior within DNA film [9].

Associations of gamma-Vinylpyridine with other chemical compounds

• Compared to any other variant, GSTA2E had lower rates of catalysis towards 1-chloro-2,4-dinitrobenzene (CDNB), 4-vinylpyridine, and cumene-, t-butyl- and arachidonic acid hydroperoxides, although kcat/Km for CDNB were similar for all four variants [10].
• We describe a GC/MS method that first reduces the disulfides in the physiological sample matrix and then immediately alkylates the free thiols with 4-vinylpyridine to prevent the reformation of the disulfide bonds [11].
• Which cysteine of apostellacyanine reacts with 4-vinylpyridine in 6 M guanidine-HC1 depends upon the pH [12].
• The reaction of Ph2PH with styrene, 4-vinylpyridine, 2-vinylpyridine, 4-methoxystyrene, 2-methoxystyrene, and 5-vinyl-2-methylpyridine in benzene under Ni[P(OEt)3]4 catalysis proceeds with high yield and selectivity to give only anti-Markovnikov product [13].
• Aggregation in nanobundles and the effect of diverse environments on the solution-phase photochemistry and photophysics of -Re(CO)3L+ (L = 1,10-phenanthroline, 2,2'-bipyridine) pendants bonded to poly(4-vinylpyridine) [14].

Gene context of gamma-Vinylpyridine

• A molecularly imprinted polymer (MIP) was prepared using (E)-piceatannol, a natural potential anti-epidermal growth factor receptor (EGFR) inhibitor, as the template and 4-vinylpyridine as the functional monomer [15].
• The biosensor was fabricated by simply syringing an aqueous solution of tyrosinase/PVAVP (PVAVP: copolymer of poly(vinyl alcohol) grafting with 4-vinylpyridine) onto glassy carbon electrode surface followed by drying the modified electrode at +4 degrees C in a refrigerator [16].
• Multilayers were composed of poly(methacrylic acid), PMAA, and poly(ethylene oxide), PEO (hydrogen-bonded multilayers), or of PMAA and 22% quarternized copolymer of N-ethyl-4-vinylpyridium bromide and 4-vinylpyridine, Q22 (electrostatically stabilized multilayers) [17].
• Using a method involving cysteine modification by 4-vinylpyridine (4-VP), 2-DE and HPLC, these peaks were identified by mass spectrometry as serum amyloid A1 (11.68 kDa) and its N-terminal arginine-truncated form (11.52 kDa) [18].

Analytical, diagnostic and therapeutic context of gamma-Vinylpyridine

• Although reductive alkylation with 4-vinylpyridine allowed direct observation of the intact beta-subunit of hCG by HPLC/MS due to the increase in charge, the heterogeneity of the carbohydrate fractions resulted in poor detection limits and extremely complex spectra [19].
• Enzyme immobilization into a positively charged polymer, poly(4-vinylpyridine-co-styrene) (PVPy), seems to cause an increase in cyanide inhibition effects because of anion accumulation in the polymeric matrix, and the resulting sensor can measure cyanide concentration in the range 10(-7)-10(-5) M [20].
• Trapping of soluble Pd with poly(4-vinylpyridine), hot filtration tests during the batchwise Heck reaction, and reaction tests of effluents from a fixed bed continuous reactor support the conclusion that leached Pd is the active phase in the Heck reaction for all of the catalysts tested [21].

References