Disease relevance of anisole

• Dermatitis from butylated hydroxy anisole [1].

Psychiatry related information on anisole

• With more reactive and/or nonvolatile reagents (anisole, xylenes, mesitylene) expeditious conditions (short reaction time at constant MW power without control of the temperature) were used [2].

High impact information on anisole

• Biomimetic model high-valent porphyrins showed reduction rates with variously 4-substituted N,N-dialkylanilines that were consistent with a positively charged intermediate; such relationships were not seen for anisole O-demethylation with P450 2B1 [3].
• The fluorescence of one of the derivatives can be efficiently quenched by the presence of electron-rich compounds such as triphenylamines, phenol or anisole, which make them very promising compounds for sensor applications [4].
• It is also shown that the product distribution for the alkylation of anisole shows significant pressure dependence with substitution at the ortho-position being favored at lower pressures, which is ascribed to hydrogen bonding [5].
• The hydrogenation of arenes containing functional groups, such as anisole, by the [Ir(0)](n) nanoparticles occurs with concomitant hydrogenolysis of the C-O bond, suggesting that these nanoparticles behave as "heterogeneous catalysts" rather than "homogeneous catalysts" [6].
• A mechanistic study of the FeO+-mediated decomposition pathways of phenol, anisol, and their thio analogues [7].

Biological context of anisole

• Two missense mutations on one allele of UGT1A6 (UGT1A6*2) result in T181A and R184S amino acid substitutions and reduced activity against phenolics, such as 4-nitrophenol, 4-hydroxycoumarin and butylated hydroxy anisole [8].
• Zinc oxide (ZnO) brings about a rapid Friedel-Crafts acylation of a range of activated and unactivated aromatic compounds such as anisole and chlorobenzene with acid chlorides in solvent-free conditions at room temperature [9].
• Hydrogen bonding-induced aromatic oligoamide foldamers as spherand analogues to accelerate the hydrolysis of nitro-substituted anisole in aqueous media [10].
• A novel anisole-based Grignard reagent was developed to effect the cyclization of sterically hindered substrates [11].
• Increased longevity, reduced fecundity, and delayed development in fruitfly (Zaprionus paravittiger) fed on butylated hydroxy anisole [12].

Anatomical context of anisole

• Effect of oxygen concentration on the metabolic pathway of anisole in rat liver microsomes [13].
• Some odors (e.g., amyl acetate and anisole) produced increased responses in the epithelium of the lateral recesses when flow rates or sniff durations were high [14].
• The effect of the antioxidant, butylated hydroxy anisole, on peroxide-induced and spontaneous activity of the uterus from the pregnant rat [15].

Associations of anisole with other chemical compounds

• Kinetic studies in dioxane-water (4:1, v/v) at 60-90 degrees C have revealed that the folded backbone of the oligomers was, like the rigidified spherand, able to complex Li+, Na+, and K+ and, consequently, accelerated the hydrolysis of the nitro-appended anisole unit of the foldamers [10].
• Palladium-catalyzed coupling of the dibromo derivative afforded the disubstituted phenyl, anisole, and acetylene derivatives, while reduction of the dinitro derivative and acetylation provided amino-dione and amide-hydroxyl derivatives [16].
• On the other hand, tert-butyl methyl ether and anisole fail to form stable boron trichloride adducts and the corresponding ether-cleaved products are obtained [17].
• The present polyoxoanion-stabilized Rh(0) nanoclusters also display a record, albeit modest, 30% selectivity for the partial hydrogenation of anisole to 1-methoxycyclohexene with an overall yield of up to 8% at higher temperatures [18].
• Oxidation was monitored using HPLC and the fluorescence properties of Triton N-101 and other alkylphenol ethoxylate detergents, which are similar to those of anisole [19].

Gene context of anisole

• N-(4-Methoxyphenylazoformyl)-L-phenylalanine is efficiently cleaved by the enzyme bovine carboxypeptidase A into fragments anisole, molecular nitrogen, carbonate, and phenylalanine, in the course of which an intense spectral absorption of the substrate (epsilon350 = 19,000 M-1 cm-1) disappears completely [20].
• Subsequent resin cleavage and deprotection of the phosphorylated peptide resins was effected by treatment with 5% anisole: TFA and gave the seven phosphopeptides in high yield and purity [21].
• Modulatory influence of arecanut on antioxidant 2(3)-tert-butyl-4-hydroxy anisole-induced hepatic detoxification system and antioxidant defence mechanism in mice [22].
• Synthetic procedures for CKII substrate peptides often result in anisole adducts and dehydrated forms [23].
• The use of anisole as an additive in the HF resin/peptide cleavage was rejected because anisole was found to undergo electrophilic substitution of the dibromoindole nucleus; a modified HF deprotection/cleavage procedure was developed and used instead [24].

Analytical, diagnostic and therapeutic context of anisole

• Isolation of liver microsomal anisole O-demethylase and aniline hydroxylase from laboratory animals by Sepharose gel filtration [25].

References