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Chemical Compound Review

chlorobutane     1-chlorobutane

Synonyms: n-Chlorobutane, sJPHADIJuP@, NBC wormer, Butyl chloride, CHEMBL47259, ...
 
 
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Disease relevance of Butyl chloride

  • We report the kinetic and structural analysis of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (LinB) in complex with each of 1,2-dichloroethane and 1,2-dichloropropane and the reaction product of 1-chlorobutane turnover [1].
  • A haloalkane dehalogenase was purified to electrophoretic homogeneity from cell extracts of a 1-chlorobutane-utilizing strain, m15-3, which was identified as a Corynebacterium sp. The enzyme hydrolyzed C2 to C12 mono- and dihalogenated alkanes, some haloalcohols, and haloacids [2].
  • In this study, a comparison was made of the hydrolysis of halogenated compounds (such as 1-chlorobutane) by lyophilized Rhodococcus erythropolis cells in a novel solid/gas biofilter and in the aqueous phase [3].
  • The apparent Michaelis-Menten constants Km and Vmax for the dehydrated Xanthobacter autotrophicus cells were 0.07 (1-chlorobutane thermodynamic activity) and 0.08 micromol min(-1) g(-1) of cells, respectively [4].
  • The melting temperature determined by the circular dichroism (41.7+/-0.3 degrees C for LinB expressed in P. pastoris and 41.8 +/- 0.3 degrees C expressed in E. coli) and thermal stability measured by specific activity to 1-chlorobutane were also similar for two enzymes [5].
 

High impact information on Butyl chloride

 

Chemical compound and disease context of Butyl chloride

 

Biological context of Butyl chloride

  • Specimens were homogenized, extracted with n-butyl chloride, and analyzed via liquid chromatography-mass spectrometry, using atmospheric pressure electrospray ionization operating in the positive mode [12].
 

Anatomical context of Butyl chloride

 

Associations of Butyl chloride with other chemical compounds

 

Gene context of Butyl chloride

  • Quetiapine was assayed in biological specimens by basic extraction with n-butyl chloride and derivatized with 50 microL of MTBSTFA and separation by GC-NPD [20].
 

Analytical, diagnostic and therapeutic context of Butyl chloride

  • The combined extracts are dried and then subjected to thin-layer chromatography on a blank Toxi-Lab Toxi-A chromatogram with 1-chlorobutane as the developing solvent (about 6 min) [21].
  • In the pulse radiolysis experiments in aqueous solution, the primary oxidants can also be observed, whereas in n-butyl chloride a transient at 325 nm remains unidentified [22].
  • Extraction was performed using liquid-liquid extraction with 1-chlorobutane, while quantification was carried out using high performance liquid chromatography equipped with a photodiode-array ultraviolet detector [23].
  • The extraction method is based on a widely used procedure employing n-butyl chloride, and instrumental analysis is performed using GC/MS and HPLC with photodiode array detection [24].

References

  1. Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition. Oakley, A.J., Prokop, Z., Bohác, M., Kmunícek, J., Jedlicka, T., Monincová, M., Kutá-Smatanová, I., Nagata, Y., Damborský, J., Wilce, M.C. Biochemistry (2002) [Pubmed]
  2. Purification and properties of haloalkane dehalogenase from Corynebacterium sp. strain m15-3. Yokota, T., Omori, T., Kodama, T. J. Bacteriol. (1987) [Pubmed]
  3. Haloalkane hydrolysis by Rhodococcus erythropolis cells: comparison of conventional aqueous phase dehalogenation and nonconventional gas phase dehalogenation. Erable, B., Goubet, I., Lamare, S., Legoy, M.D., Maugard, T. Biotechnol. Bioeng. (2004) [Pubmed]
  4. Nonconventional hydrolytic dehalogenation of 1-chlorobutane by dehydrated bacteria in a continuous solid-gas biofilter. Erable, B., Goubet, I., Lamare, S., Seltana, A., Legoy, M.D., Maugard, T. Biotechnol. Bioeng. (2005) [Pubmed]
  5. Expression of glycosylated haloalkane dehalogenase LinB in Pichia pastoris. Nakamura, T., Zámocký, M., Zdráhal, Z., Chaloupková, R., Monincová, M., Prokop, Z., Nagata, Y., Damborský, J. Protein Expr. Purif. (2006) [Pubmed]
  6. Isolation and chemical characterization of 2-hydroxybenzoylglycine as a drug binding inhibitor in uremia. Lichtenwalner, D.M., Suh, B., Lichtenwalner, M.R. J. Clin. Invest. (1983) [Pubmed]
  7. Light-scattering study of the aggregation of syndiotactic poly(methyl methacrylate) in solution. Chen, W., Zhao, Y., Jiang, Y., Yan, D., Han, C.C. Chemphyschem : a European journal of chemical physics and physical chemistry. (2004) [Pubmed]
  8. Reversed-phase liquid-chromatographic simultaneous analysis for thiopental and pentobarbital in serum. Kelner, M., Bailey, D.N. Clin. Chem. (1983) [Pubmed]
  9. The effect of inert salts on the structure of the transition state in the SN2 reaction between thiophenoxide ion and butyl chloride. Westaway, K.C., Gao, Y., Fang, Y.R. J. Org. Chem. (2003) [Pubmed]
  10. Roles of horizontal gene transfer and gene integration in evolution of 1,3-dichloropropene- and 1,2-dibromoethane-degradative pathways. Poelarends, G.J., Kulakov, L.A., Larkin, M.J., van Hylckama Vlieg, J.E., Janssen, D.B. J. Bacteriol. (2000) [Pubmed]
  11. Enzymatic dehalogenation of gas phase substrates with haloalkane dehalogenase. Dravis, B.C., LeJeune, K.E., Hetro, A.D., Russell, A.J. Biotechnol. Bioeng. (2000) [Pubmed]
  12. Brain distribution of selected antipsychotics in schizophrenia. Rodda, K.E., Dean, B., McIntyre, I.M., Drummer, O.H. Forensic Sci. Int. (2006) [Pubmed]
  13. A report on the analysis of orphenadrine in post mortem specimens. Wilkinson, L.F., Thomson, B.M., Pannell, L.K. Journal of analytical toxicology. (1983) [Pubmed]
  14. A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism. Lin, S.N., Chang, Y., Moody, D.E., Foltz, R.L. Journal of analytical toxicology. (2004) [Pubmed]
  15. Sensitive high-performance liquid chromatographic assay using 9-fluorenylmethylchloroformate for monitoring controlled-release lidocaine in plasma. Sintov, A., Siden, R., Levy, R.J. J. Chromatogr. (1989) [Pubmed]
  16. Analysis of encainide and metabolites in plasma and urine by high-performance liquid chromatography. Bartek, M.J., Mayol, R.F., Boarman, M.P., Gammans, R.E., Gallo, D.G. Therapeutic drug monitoring. (1988) [Pubmed]
  17. Ionization of aniline and its N-methyl and N-phenyl substituted derivatives by (free) electron transfer to n-butyl chloride parent radical cations. Maroz, A., Hermann, R., Naumov, S., Brede, O. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  18. Analysis of vinylidene chloride and 1-chlorobutane in foods packaged with polyvinylidene chloride casing films by headspace gas chromatography/mass spectrometry (GC/MS). Ohno, H., Kawamura, Y. Food additives and contaminants. (2006) [Pubmed]
  19. Two cases of fatal zopiclone overdose. Boniface, P.J., Russell, S.G. Journal of analytical toxicology. (1996) [Pubmed]
  20. Fatal overdoses associated with quetiapine. Langman, L.J., Kaliciak, H.A., Carlyle, S. Journal of analytical toxicology. (2004) [Pubmed]
  21. Efficient extraction of basic, neutral, and weakly acidic drugs from plasma for analysis by gas chromatography-mass spectrometry. Brooks, K.E., Smith, N.B. Clin. Chem. (1991) [Pubmed]
  22. Radical cations of phenyl-substituted aziridines: what are the conditions for ring opening? Gaebert, C., Mattay, J., Toubartz, M., Steenken, S., Müller, B., Bally, T. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  23. Stability of benzodiazepines in whole blood samples stored at varying temperatures. El Mahjoub, A., Staub, C. Journal of pharmaceutical and biomedical analysis. (2000) [Pubmed]
  24. Analysis of sertraline (Zoloft) and its major metabolite in postmortem specimens by gas and liquid chromatography. Logan, B.K., Friel, P.N., Case, G.A. Journal of analytical toxicology. (1994) [Pubmed]
 
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