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Chemical Compound Review

Surital     5-pentan-2-yl-5-prop-2-enyl- 2...

Synonyms: thiamylal, Thioseconal, CHEMBL440, AC1MHTV0, CHEBI:9536, ...
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Disease relevance of Surital


Psychiatry related information on Surital


High impact information on Surital

  • For high-performance liquid chromatography (HPLC) of thiamylal, one of the barbiturates, the drug in serum samples was extracted by two alternative liquid-liquid extraction techniques using hydrophilic acetonitrile as a solvent and subzero-temperature and salting-out methods [8].
  • A comparison of the long-term follow-up results of chronic motor cortex stimulation therapy revealed that thiamylal and ketamine-sensitive and morphine-resistant cases displayed long-lasting pain reduction with chronic motor cortex stimulation therapy, whereas the remaining cases did not show good results [9].
  • During 105 min of anesthesia (induced by thiamylal sodium and maintained by halothane and oxygen), PRL increased (8.2 +/- 1.9 ng/ml) in all gilts [10].
  • The plasma PRL and TSH responses to TRH injected iv at different stages of the estrous cycle in normal rats under Surital anesthesia were maximal during the afternoon of proestrus and morning of estrus and lowest on diestrus I [11].
  • Measurement of thiamylal and thiopental in plasma by electron capture and flame photometric gas-liquid chromatography [12].

Chemical compound and disease context of Surital


Biological context of Surital


Anatomical context of Surital

  • In the mesenteric artery soaked in Ca++-free media, the addition of Ca++ produced only a slight contraction, which was potentiated by thiamylal (10(-4) and 10(-3) M) [23].
  • Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes [1].
  • METHODS: The authors used inside-out patch clamp configurations to investigate the effects of propofol and thiamylal on the activity of recombinant KATP channels using COS-7 cells transfected with various types of KATP channel subunits [24].
  • The thiamylal-induced contraction appears to be associated mainly with influx of Ca++ from extracellular fluids [23].
  • In helical strips of dog cerebral, coronary, mesenteric, renal, and femoral arteries, the addition of thiamylal and thiopental, 10(-5) to 10(-3) M, caused a dose-related contraction; the contraction was significantly more intense in cerebral than in extracerebral arteries [23].

Associations of Surital with other chemical compounds


Gene context of Surital


Analytical, diagnostic and therapeutic context of Surital


  1. Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes. Tsutsumi, Y., Oshita, S., Kitahata, H., Kuroda, Y., Kawano, T., Nakaya, Y. Anesthesiology (2000) [Pubmed]
  2. Seizure-like movements during induction of anaesthesia with sevoflurane. Adachi, M., Ikemoto, Y., Kubo, K., Takuma, C. British journal of anaesthesia. (1992) [Pubmed]
  3. Cerebral arteriovenous oxygen content difference during barbiturate therapy in patients with acute brain damage. Sari, A., Matayoshi, Y., Yonei, A., Ogasahara, H., Nonoue, T., Yokota, K., Yamashita, S. Anesth. Analg. (1986) [Pubmed]
  4. Effect of midazolam preanesthetic administration on thiamylal induction requirement in dogs. Tranquilli, W.J., Graning, L.M., Thurmon, J.C., Benson, G.J., Moum, S.G., Lentz, E.L. Am. J. Vet. Res. (1991) [Pubmed]
  5. Arrhythmias in dogs associated with epinephrine and thiamylal anesthesia. Muir, W.W., Werner, L.L., Hamlin, R.L. Am. J. Vet. Res. (1975) [Pubmed]
  6. Presynaptic inhibition in man during anesthesia and sleep. Shimoji, K., Ito, Y., Oama, K., Sawa, T., Ikezono, E. Anesthesiology (1975) [Pubmed]
  7. Electroconvulsive therapy with thiamylal or propofol during pregnancy. Iwasaki, K., Sakamoto, A., Hoshino, T., Ogawa, R. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2002) [Pubmed]
  8. Extraction of thiamylal in serum using hydrophilic acetonitrile with subzero-temperature and salting-out methods. Yoshida, M., Akane, A., Nishikawa, M., Watabiki, T., Tsuchihashi, H. Anal. Chem. (2004) [Pubmed]
  9. Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy. Yamamoto, T., Katayama, Y., Hirayama, T., Tsubokawa, T. Pain (1997) [Pubmed]
  10. Prolactin secretion after hypophysial stalk transection in pigs. Anderson, L.L., Berardinelli, J.G., Malven, P.V., Ford, J.J. Endocrinology (1982) [Pubmed]
  11. Changes of pituitary thyrotropin releasing hormone (TRH) receptor level and prolactin response to TRH during the rat estrous cycle. Léan, A.D., Garon, M., Kelly, P.A., Labrie, F. Endocrinology (1977) [Pubmed]
  12. Measurement of thiamylal and thiopental in plasma by electron capture and flame photometric gas-liquid chromatography. Smith, R.H., MacDonald, J.A., Thompson, D.S., Flacke, W.E. Clin. Chem. (1977) [Pubmed]
  13. Cardiovascular effects of vasopressors in halothane-anesthetized dogs before and after hemorrhage. Curtis, M.B., Bednarski, R.M., Majors, L. Am. J. Vet. Res. (1989) [Pubmed]
  14. Potency of rapidly acting barbiturates in dogs, using inhibition of the laryngeal reflex as the end point. Turner, D.M., Ilkiw, J.E. Am. J. Vet. Res. (1990) [Pubmed]
  15. Cardiovascular effects of vasopressors in isoflurane-anesthetized dogs before and after hemorrhage. Curtis, M.B., Bednarski, R.M., Majors, L. Am. J. Vet. Res. (1989) [Pubmed]
  16. Sensitivity to vecuronium in myasthenia gravis: a dose-response study. Eisenkraft, J.B., Book, W.J., Papatestas, A.E. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1990) [Pubmed]
  17. Effect of hypercapnia on the arrhythmogenic dose of epinephrine in horses anesthetized with guaifenesin, thiamylal sodium, and halothane. Gaynor, J.S., Bednarski, R.M., Muir, W.W. Am. J. Vet. Res. (1993) [Pubmed]
  18. Clonidine decreases the dose of thiamylal required to induce anesthesia in children. Nishina, K., Mikawa, K., Maekawa, N., Takao, Y., Obara, H. Anesth. Analg. (1994) [Pubmed]
  19. Protein binding and the metabolism of thiamylal enantiomers in vitro. Sueyasu, M., Fujito, K., Shuto, H., Mizokoshi, T., Kataoka, Y., Oishi, R. Anesth. Analg. (2000) [Pubmed]
  20. Inotropic and electrophysiologic effects of propofol and thiamylal in isolated papillary muscles of the guinea pig and the rat. Azuma, M., Matsumura, C., Kemmotsu, O. Anesth. Analg. (1993) [Pubmed]
  21. The effects of sevoflurane, isoflurane, halothane, and enflurane on hemodynamic responses during an inhaled induction of anesthesia via a mask in humans. Tanaka, S., Tsuchida, H., Nakabayashi, K., Seki, S., Namiki, A. Anesth. Analg. (1996) [Pubmed]
  22. Thiamylal and pentobarbital have opposite effects on human platelet aggregation in vitro. Sato, M., Hirakata, H., Nakagawa, T., Arai, K., Fukuda, K. Anesth. Analg. (2003) [Pubmed]
  23. The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbiturates and thiobarbiturates. Hatano, Y., Nakamura, K., Moriyama, S., Mori, K., Toda, N. Anesthesiology (1989) [Pubmed]
  24. Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Kawano, T., Oshita, S., Takahashi, A., Tsutsumi, Y., Tomiyama, Y., Kitahata, H., Kuroda, Y., Nakaya, Y. Anesthesiology (2004) [Pubmed]
  25. Desflurane and isoflurane produce similar alterations in systemic and pulmonary hemodynamics and arterial oxygenation in patients undergoing one-lung ventilation during thoracotomy. Pagel, P.S., Fu, J.L., Damask, M.C., Davis, R.F., Samuelson, P.N., Howie, M.B., Warltier, D.C. Anesth. Analg. (1998) [Pubmed]
  26. Circulatory changes in patients with coronary artery disease following thiamylal-succinylcholine and tracheal intubation. Stoelting, R.K., Peterson, C. Anesth. Analg. (1976) [Pubmed]
  27. Postanesthetic hepatic injury in rats: influence of alterations in hepatic blood flow, surgery, and anesthesia time. Harper, M.H., Collins, P., Johnson, B.H., Eger, E.I., Biava, C.G. Anesth. Analg. (1982) [Pubmed]
  28. Inhibition by six somatostatin analogs of plasma growth hormone levels stimulated by thiamylal and morphine in the rat. Ferland, L., Labrie, F., Coy, D.H., Arimura, A., Schally, A.V. Mol. Cell. Endocrinol. (1976) [Pubmed]
  29. Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices. Zhan, R.Z., Fujiwara, N., Yamakura, T., Taga, K., Fukuda, S., Shimoji, K. British journal of anaesthesia. (1998) [Pubmed]
  30. Intraarterial injection of 2.5% thiamylal does cause gangrene. Dohi, S., Naito, H. Anesthesiology (1983) [Pubmed]
  31. The effects of thiamylal sodium on the tonic vibration reflex in man. Hori, Y., Hiraga, K., Watanabe, S. Brain Res. (1989) [Pubmed]
  32. Determination of thiopental in human serum and plasma by high-performance capillary electrophoresis-micellar electrokinetic chromatography. Meier, P., Thormann, W. J. Chromatogr. (1991) [Pubmed]
  33. Heart-rate slowing and junctional rhythm following intravenous succinylcholine with and without intramuscular atropine preanesthetic medication. Stoelting, R.K., Peterson, C. Anesth. Analg. (1975) [Pubmed]
  34. Complete recovery of consciousness in a patient with decorticate rigidity following cardiac arrest after thoracic epidural injection. Taga, K., Tomita, M., Watanabe, I., Sato, K., Awamori, K., Fujihara, H., Shimoji, K. British journal of anaesthesia. (2000) [Pubmed]
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