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Chemical Compound Review:

EGEEA 2-ethoxyethyl ethanoate

Synonyms: CSAC, Celosolvacetat, HSDB 539, NSC-8658, ACMC-1C1FF, ...

Hardin, B.D. et al., Lowry, L.K. et al., Stott, W.T. et al., Paustenbach, D.J., Johanson, G. et al., et al.

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Disease relevance of Acetato di cellosolve

2-ethoxyethyl acetate at 600 ppm induced complete resorption of litters; 390 ppm reduced fetal weights and induced skeletal and cardiovascular defects, but only a single defect was observed at 130 ppm [1].
EGEE- and EGEEA-treated rats showed a reduction in body weight relative to water controls that was associated with completely resorbed litters and significantly fewer live fetuses per litter [2].
Numerous reproductive and developmental toxicity studies, across several species, involving various routes of administration, indicate that Ethoxyethanol and Ethoxyethanol Acetate are reproductive toxicants and teratogens [3].

High impact information on Acetato di cellosolve

In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glycol monoethyl ether (diEGEE) were tested in the same experimental model, using distilled water as the negative control and EGEE as a positive control [2].
An inhalation teratology study using ethylene glycol monoethyl ether acetate (EGEEA) has been conducted in rabbits at 25, 100 and 400 ppm [4].
Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies [4].
Pulmonary and percutaneous absorption of 2-propoxyethyl acetate and 2-ethoxyethyl acetate in beagle dogs [5].
Methoxyethanol (ethylene glycol monomethyl ether, EGME), ethoxyethanol (ethylene glycol monoethyl ether, EGEE), and ethoxyethyl acetate (ethylene glycol monoethyl ether acetate, EGEEA) are all developmental toxicants in laboratory animals [6].

Biological context of Acetato di cellosolve

A practical application of urinary 2-ethoxyacetic acid (EAA) to assess occupational exposure to 2-ethoxyethyl acetate (EGEE-Ac) during a large format silk-screening operation is described [7].
Applications of biological monitoring in occupational health practice: practical application of urinary 2-ethoxyacetic acid to assess exposure to 2-ethoxyethyl acetate in large format silk-screening operations [7].

Anatomical context of Acetato di cellosolve

CONCLUSION: The high rate of possible haematological effects among shipyard painters and a hygienic evaluation of their working environment in the present study suggests that EGEEA might be toxic to bone marrow [8].

Associations of Acetato di cellosolve with other chemical compounds

Liquid/air partition coefficients (pcs) of six commonly used glycol ethers (2-methoxyethanol (ME), 2-ethoxyethanol (EE), 2-isopropoxyethanol (PE), 2-butoxyethanol (BE), 2-ethoxyethyl acetate (EEA), and 1-methoxy-2-propanol (MP] were determined in vitro using a head space technique [9].
This risk assessment evaluates the potential human hazards of adverse developmental effects posed by exposure to 2-ethoxyethanol (2-EE), 2-ethoxyethanol acetate (2-EEA), 2-methoxyethanol (2-ME), and 2-methoxyethanol acetate (2-MEA) as they are currently used in semiconductor manufacturing [10].
Apparent Vmax and Km values were obtained for mouse nasal carboxylesterase using ethylene glycol monomethyl ether acetate (EGMEAc), ethylene glycol monoethyl ether acetate (EGEEAc), propylene glycol monomethyl ether acetate (PGMEAc), methyl acrylate (ME), ethyl acrylate (EA), and butyl acrylate (BA) as substrates [11].

References

Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Nelson, B.K., Setzer, J.V., Brightwell, W.S., Mathinos, P.R., Kuczuk, M.H., Weaver, T.E., Goad, P.T. Environ. Health Perspect. (1984) [Pubmed]
Developmental toxicity of four glycol ethers applied cutaneously to rats. Hardin, B.D., Goad, P.T., Burg, J.R. Environ. Health Perspect. (1984) [Pubmed]
Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Johnson, W. International journal of toxicology. (2002) [Pubmed]
Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies. Doe, J.E. Environ. Health Perspect. (1984) [Pubmed]
Pulmonary and percutaneous absorption of 2-propoxyethyl acetate and 2-ethoxyethyl acetate in beagle dogs. Guest, D., Hamilton, M.L., Deisinger, P.J., DiVincenzo, G.D. Environ. Health Perspect. (1984) [Pubmed]
Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations. Sweeney, L.M., Tyler, T.R., Kirman, C.R., Corley, R.A., Reitz, R.H., Paustenbach, D.J., Holson, J.F., Whorton, M.D., Thompson, K.M., Gargas, M.L. Toxicol. Sci. (2001) [Pubmed]
Applications of biological monitoring in occupational health practice: practical application of urinary 2-ethoxyacetic acid to assess exposure to 2-ethoxyethyl acetate in large format silk-screening operations. Lowry, L.K., Stumpp, D.A., Orbaugh, C., Rieders, F. International archives of occupational and environmental health. (1993) [Pubmed]
Evaluation of exposure to ethylene glycol monoethyl ether acetates and their possible haematological effects on shipyard painters. Kim, Y., Lee, N., Sakai, T., Kim, K.S., Yang, J.S., Park, S., Lee, C.R., Cheong, H.K., Moon, Y. Occupational and environmental medicine. (1999) [Pubmed]
Liquid/air partition coefficients of six commonly used glycol ethers. Johanson, G., Dynésius, B. British journal of industrial medicine. (1988) [Pubmed]
Assessment of the developmental risks resulting from occupational exposure to select glycol ethers within the semiconductor industry. Paustenbach, D.J. Journal of toxicology and environmental health. (1988) [Pubmed]
Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Stott, W.T., McKenna, M.J. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1985) [Pubmed]

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