Disease relevance of Emkanol

• Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberrations in cultured cells [1].
• The routes of 14C excretion following the administration of a single oral 230 mg/kg body weight dose of 2-ethoxyethanol [ethanol-1,2-14C] or 2-ethoxyethanol [ethoxy-1-14C] to male Sprague-Dawley rats were investigated [2].
• Neither EGM nor EGE produced any morphological evidence of toxicity when added to the culture medium at up to 50 mM for 72 hr [3].

High impact information on Emkanol

• Twenty-microns-thick sections of GMA-embedded tonsil were either pretreated with an organic solvent (absolute ethanol or 2-ethoxyethanol) followed by rehydration in phosphate buffered saline (PBS) or directly rehydrated in PBS [4].
• Previous research demonstrated the inhalation teratogenicity of the solvent 2-ethoxyethanol in rats and rabbits [5].
• This research indicates that the industrial solvent 2-ethoxyethanol presents an occupational reproductive hazard and raises the issue of the importance of an interaction of social habits with occupational exposure to such hazards [6].
• Visceral malformations and skeletal variations were significantly increased in EGEE and EGEEA groups over the negative control group [7].
• Percutaneous absorption and cutaneous metabolism of 2-ethoxyethanol were assessed in vivo and with an in vitro flow-through diffusion system [8].

Chemical compound and disease context of Emkanol

• The toxicity of 2-methoxyethanol and 2-ethoxyethanol was underestimated due to a lack of metabolic capacity in the EST [9].
• Triethylene glycol has replaced 2-ethoxyethanol because of reported toxicity [10].

Biological context of Emkanol

• 2-ethoxyethanol, a solvent developed for nitrocellulose and also used in lacquers, dyes, varnish removers, and in numerous industrial processes, was evaluated for possible functional effects in offspring of rats exposed during gestation [11].
• Since the primary targets of EGME and EGEE appear to be tissues with rapidly dividing cell systems and high rates of respiration and energy metabolism, the effects of these compounds and their proposed metabolites on mitochondria were investigated [12].

Anatomical context of Emkanol

• However, rat skin cytosol had the potential to metabolize ethoxyethanol, suggesting that the rapid penetration through skin in vivo prevented metabolism and that systemic exposure after skin contact with 2-ethoxyethanol is likely to be to the parent compound [8].
• We mounted the mucosa from the membranous canine trachea in an Ussing-type diffusion cell and measured the diffusion coefficient of 2-ethoxyethanol (2-Ethx; lambda o:w = 0.042), EtOH, and methyl ethyl ketone (MEK; lambda o:w = 1.04) in the presence and absence of the epithelial tight junction [13].
• Primary mixed cultures of Sertoli and germ cells were prepared from testes of immature rats and their response to the known testicular toxicants ethylene glycol monomethyl ether (EGM) and ethylene glycol monoethyl ether (EGE) was studied [3].
• To determine whether 2-ethoxyethanol (2-EE) and 2-methoxyethanol (2-ME) affected the reproductive potential of exposed men, we examined the semen of 73 painters and 40 controls who work in a large shipyard [14].

Associations of Emkanol with other chemical compounds

• Initial rationale for addition of 2-ethoxyethanol was to minimize inhibitory effects of decalin on filtration and to facilitate starch solubilization [15].

Gene context of Emkanol

• Suggested modifications to the NDF procedure include elimination of 2-ethoxyethanol and addition of alpha-amylase just prior to filtering [15].

Analytical, diagnostic and therapeutic context of Emkanol

• The determination of environmental 2-ethoxyethanol by gas chromatography [16].
• Subsequently the desorbed 2-ethoxyethanol can be analyzed by gas chromatographic identification on 10% FFAP using a flame ionization detector [16].
• To evaluate whether long term exposure to 2-ethoxyethanol (2EE) may affect semen quality, a cross sectional study was conducted among men exposed to 2EE used as a binder slurry in a metal castings process [17].
• Effects of 2-ethoxyethanol (EE) on semen parameters in male rats were investigated employing an animal model that allowed assessment of toxicity and recovery in the same animal [18].

References