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Chemical Compound Review

Corbuton     4-butyl-1-phenyl- pyrazolidine-3,5-dione

Synonyms: Monazone, Reumatox, Mobutazon, Mobuzon, Monazan, ...
 
 
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Disease relevance of Mofebutazone

 

High impact information on Mofebutazone

 

Chemical compound and disease context of Mofebutazone

 

Biological context of Mofebutazone

 

Anatomical context of Mofebutazone

  • Tin from them became cell associated only in the cases of monobutyl- and monophenyl tin, which were bound at markedly lower levels (<0.1 mM Sn/g cells) [18].
 

Associations of Mofebutazone with other chemical compounds

  • A method for the determination of organotin compounds (monobutyl = MBT, dibutyl = DBT, and tributyltin = TBT) in marine sediments by headspace Solid Phase Microextraction (SPME) has been developed [19].
  • The main inputs of tributyl-tin (TBT), along with degradation products di- and monobutyl-tin (DBT and MBT), were detected in the estuarine zone, due to high discharge from shipyards located in this area [20].
 

Gene context of Mofebutazone

  • Male rats were administered diets containing monobutyl (MBP), mono-iso-butyl (MIBP), monooctyl (MOP) or mono-2-ethylhexyl phthalate (MEHP) for 1 week, and serum lipid compositions were determined [21].
  • Dietary administration of monobutyl (MBP), mono-iso-butyl (MIBP) and mono-2-ethylhexyl phthalate (MEHP) induced severe atrophy of the testes [22].
  • Two pyrazolon derivatives--mofebutazone (CAS 2210-63-1) and phenylbutazone (CAS 50-33-9)--were compared as to their effects on the adenosine triphosphate (ATP) level of polymorphonuclear cells (PMNs) and their response to the migration of these cells [23].
 

Analytical, diagnostic and therapeutic context of Mofebutazone

References

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  8. Subchronic exposure to low concentrations of di-n-butyl phthalate disrupts spermatogenesis in Xenopus laevis frogs. Lee, S.K., Veeramachaneni, D.N. Toxicol. Sci. (2005) [Pubmed]
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  10. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Ghanayem, B.I., Blair, P.C., Thompson, M.B., Maronpot, R.R., Matthews, H.B. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
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  24. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Duty, S.M., Singh, N.P., Silva, M.J., Barr, D.B., Brock, J.W., Ryan, L., Herrick, R.F., Christiani, D.C., Hauser, R. Environ. Health Perspect. (2003) [Pubmed]
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