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Chemical Compound Review

Corbuton     4-butyl-1-phenyl- pyrazolidine-3,5-dione

Synonyms: Monazone, Reumatox, Mobutazon, Mobuzon, Monazan, ...
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Disease relevance of Mofebutazone


High impact information on Mofebutazone


Chemical compound and disease context of Mofebutazone


Biological context of Mofebutazone


Anatomical context of Mofebutazone

  • Tin from them became cell associated only in the cases of monobutyl- and monophenyl tin, which were bound at markedly lower levels (<0.1 mM Sn/g cells) [18].

Associations of Mofebutazone with other chemical compounds

  • A method for the determination of organotin compounds (monobutyl = MBT, dibutyl = DBT, and tributyltin = TBT) in marine sediments by headspace Solid Phase Microextraction (SPME) has been developed [19].
  • The main inputs of tributyl-tin (TBT), along with degradation products di- and monobutyl-tin (DBT and MBT), were detected in the estuarine zone, due to high discharge from shipyards located in this area [20].

Gene context of Mofebutazone

  • Male rats were administered diets containing monobutyl (MBP), mono-iso-butyl (MIBP), monooctyl (MOP) or mono-2-ethylhexyl phthalate (MEHP) for 1 week, and serum lipid compositions were determined [21].
  • Dietary administration of monobutyl (MBP), mono-iso-butyl (MIBP) and mono-2-ethylhexyl phthalate (MEHP) induced severe atrophy of the testes [22].
  • Two pyrazolon derivatives--mofebutazone (CAS 2210-63-1) and phenylbutazone (CAS 50-33-9)--were compared as to their effects on the adenosine triphosphate (ATP) level of polymorphonuclear cells (PMNs) and their response to the migration of these cells [23].

Analytical, diagnostic and therapeutic context of Mofebutazone


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