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Chemical Compound Review

OCBA     2-chlorobenzoic acid

Synonyms: chlorobenzoate, SureCN367, PubChem22283, CHEMBL115243, CCRIS 5993, ...
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Disease relevance of HSDB 6017


High impact information on HSDB 6017


Chemical compound and disease context of HSDB 6017


Biological context of HSDB 6017


Associations of HSDB 6017 with other chemical compounds

  • Dicamba (25 micro mol/mg mitochondrial protein) collapses, almost completely, Deltapsi; similar concentrations of 2-chlorobenzoic acid promote Deltapsi drops of about 50% [13].

Gene context of HSDB 6017

  • Degradation of 2-chlorobenzoic acid (2-CBA), a model recalcitrant chlorinated organic compound, by pure cultures of Burkholderia cepacia strain DNT with (transformed B. cepacia) and without (untransformed B. cepacia) the bacterial hemoglobin (Vitreoscilla hemoglobin, VHb) gene, vgb, was investigated in parallel membrane bioreactors (MBRs) [14].

Analytical, diagnostic and therapeutic context of HSDB 6017


  1. Real-time reverse transcription-PCR analysis of expression of halobenzoate and salicylate catabolism-associated operons in two strains of Pseudomonas aeruginosa. Corbella, M.E., Puyet, A. Appl. Environ. Microbiol. (2003) [Pubmed]
  2. Expression of 2-halobenzoate dioxygenase genes (cbdSABC) involved in the degradation of benzoate and 2-halobenzoate in Burkholderia sp. TH2. Suzuki, K., Ogawa, N., Miyashita, K. Gene (2001) [Pubmed]
  3. Characterization and regulation of the genes for a novel anthranilate 1,2-dioxygenase from Burkholderia cepacia DBO1. Chang, H.K., Mohseni, P., Zylstra, G.J. J. Bacteriol. (2003) [Pubmed]
  4. Isolation and characterization of a new plasmid from a Flavobacterium sp. which carries the genes for degradation of 2,4-dichlorophenoxyacetate. Chaudhry, G.R., Huang, G.H. J. Bacteriol. (1988) [Pubmed]
  5. Characterization of hybrid toluate and benzoate dioxygenases. Ge, Y., Eltis, L.D. J. Bacteriol. (2003) [Pubmed]
  6. Cloning, expression, and nucleotide sequence of the Pseudomonas aeruginosa 142 ohb genes coding for oxygenolytic ortho dehalogenation of halobenzoates. Tsoi, T.V., Plotnikova, E.G., Cole, J.R., Guerin, W.F., Bagdasarian, M., Tiedje, J.M. Appl. Environ. Microbiol. (1999) [Pubmed]
  7. Genetic exchange in soil between introduced chlorobenzoate degraders and indigenous biphenyl degraders. Focht, D.D., Searles, D.B., Koh, S.C. Appl. Environ. Microbiol. (1996) [Pubmed]
  8. The Absorption, Metabolism, and Excretion of the Novel Neuromodulator RWJ-333369 (1,2-Ethanediol, [1-2-Chlorophenyl]-, 2-carbamate, [S]-) in Humans. Mannens, G.S., Hendrickx, J., Janssen, C.G., Chien, S., Van Hoof, B., Verhaeghe, T., Kao, M., Kelley, M.F., Goris, I., Bockx, M., Verreet, B., Bialer, M., Meuldermans, W. Drug Metab. Dispos. (2007) [Pubmed]
  9. A novel metabolite in the microbial degradation of 2-chlorobenzoate. Fetzner, S., Müller, R., Lingens, F. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  10. Pseudomonas aeruginosa 142 uses a three-component ortho-halobenzoate 1,2-dioxygenase for metabolism of 2,4-dichloro- and 2-chlorobenzoate. Romanov, V., Hausinger, R.P. J. Bacteriol. (1994) [Pubmed]
  11. Metabolic engineering of bacteria for environmental applications: construction of Pseudomonas strains for biodegradation of 2-chlorotoluene. Haro, M.A., de Lorenzo, V. J. Biotechnol. (2001) [Pubmed]
  12. Synthesis and chemical characterization of 2-methoxy-N(10)-substituted acridones needed to reverse vinblastine resistance in multidrug resistant (MDR) cancer cells. Krishnegowda, G., Thimmaiah, P., Hegde, R., Dass, C., Houghton, P.J., Thimmaiah, K.N. Bioorg. Med. Chem. (2002) [Pubmed]
  13. Comparative effects of herbicide dicamba and related compound on plant mitochondrial bioenergetics. Peixoto, F., Vicente, J.A., Madeira, V.M. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  14. Comparison of 2-chlorobenzoic acid biodegradation in a membrane bioreactor by B. cepacia and B. cepacia bearing the bacterial hemoglobin gene. Urgun-Demirtas, M., Stark, B.C., Pagilla, K.R. Water Res. (2006) [Pubmed]
  15. Real-time PCR quantification of a green fluorescent protein-labeled, genetically engineered Pseudomonas putida strain during 2-chlorobenzoate degradation in soil. Wang, G., Gentry, T.J., Grass, G., Josephson, K., Rensing, C., Pepper, I.L. FEMS Microbiol. Lett. (2004) [Pubmed]
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