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Chemical Compound Review

Lipamide     5-(dithiolan-3-yl)pentanamide

Synonyms: Lipoacin, Lipoamid, Lipoicin, Lipozyme, Lypoaran, ...
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Disease relevance of Thioctamid


High impact information on Thioctamid


Biological context of Thioctamid

  • The enzymatic hydrolysis of the oil was carried out in supercritical carbon dioxide using lipase Lipozyme as catalyst and changes in the composition of acylglycerols were recorded [9].
  • The objective of this research was to study the kinetics of synthesis of a commercially important ester - Isopropyl Palmitate (IPP) using immobilized lipase (Lipozyme IM) [10].

Associations of Thioctamid with other chemical compounds

  • Esterification of rapeseed oil fatty acids with glycerol in vacuo at 60 degrees C, catalyzed by Lipozyme RM and lipases from Thermomyces lanuginosus (Lipozyme TL IM) and Candida antarctica (lipase B, Novozym 435), also provided diacylglycerols, however, to a lower extent (40-45%) [11].
  • At shake-flask level, maximum yields of 37.5 and 40% were observed in case of palmitoyl and stearoyl lactic acids, respectively, with Lipozyme IM20; at bench-scale level, the maximum yields were 85.1 and 99% respectively, when PPL was employed [7].
  • A commercially immobilized 1,3-specific lipase, Lipozyme IM, from Rhizomucormiehei, was the biocatalyst and caprylic acid the acyl donor [12].
  • The 1,3-regiospecifique lipase, Lipozyme IM, catalyzed the esterification of lauric acid and glycerol in a homogeneous system [13].

Gene context of Thioctamid


  1. Development of small-size tubular-flow continuous reactors for the analysis of operational stability of enzymes in low-water systems. Pirozzi, D., Halling, P.J. Biotechnol. Bioeng. (2001) [Pubmed]
  2. Effect of alpha lipoic acid amide on hexachlorobenzene porphyria. Vilas, G.L., Aldonatti, C., San Martín de Viale, L.C., Ríos de Molina, M.C. Biochem. Mol. Biol. Int. (1999) [Pubmed]
  3. Enzyme catalyzed synthesis of some vinyl drug esters in organic medium. Lv, D.S., Xue, X.T., Wang, N., Wu, Q., Lin, X.F. Prep. Biochem. Biotechnol. (2004) [Pubmed]
  4. Lipase specificity toward some acetylenic and olefinic alcohols in the esterification of pentanoic and stearic acids. Lie Ken Jie, M.S., Xun, F. Lipids (1998) [Pubmed]
  5. Candida rugosa lipase LIP1-catalyzed transesterification to produce human milk fat substitute. Srivastava, A., Akoh, C.C., Chang, S.W., Lee, G.C., Shaw, J.F. J. Agric. Food Chem. (2006) [Pubmed]
  6. Lipase-catalysed transesterification of soya bean oil for biodiesel production during continuous batch operation. Du, W., Xu, Y., Liu, D. Biotechnol. Appl. Biochem. (2003) [Pubmed]
  7. Lipase catalyzed synthesis of organic acid esters of lactic acid in non-aqueous media. Kiran, K.R., Divakar, S. J. Biotechnol. (2001) [Pubmed]
  8. Synthesis of structured triacylglycerols containing caproic acid by lipase-catalyzed acidolysis: optimization by response surface methodology. Zhou, D., Xu, X., Mu, H., Høy, C.E., Adler-Nissen, J. J. Agric. Food Chem. (2001) [Pubmed]
  9. HPLC in reversed phase mode: Tool for investigation of kinetics of blackcurrant seed oil lipolysis in supercritical carbon dioxide. Bártlová, M., Bernásek, P., Sýkora, J., Sovová, H. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]
  10. Studies on the kinetics of Isopropyl Palmitate synthesis in packed bed bioreactor using immobilized lipase. Kee, C.Y., Hassan, M., Ramachandran, K.B. Artificial cells, blood substitutes, and immobilization biotechnology. (1999) [Pubmed]
  11. Solvent-free lipase-catalyzed preparation of diacylglycerols. Weber, N., Mukherjee, K.D. J. Agric. Food Chem. (2004) [Pubmed]
  12. Synthesis of structured triacylglycerols by lipase-catalyzed acidolysis in a packed bed bioreactor. Xu, X., Fomuso, L.B., Akoh, C.C. J. Agric. Food Chem. (2000) [Pubmed]
  13. Lipase-catalyzed synthesis of monoacylglycerol in a homogeneous system. Monteiro, J.B., Nascimento, M.G., Ninow, J.L. Biotechnol. Lett. (2003) [Pubmed]
  14. In vitro development and evaluation of prolidase lipozyme. Hu, M. PDA journal of pharmaceutical science and technology / PDA. (1997) [Pubmed]
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