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Chemical Compound Review

Icr-170     N-(2-chloroethyl)-N'-(6- chloro-2-methoxy...

Synonyms: CCRIS 1091, CHEBI:21183, ICR 170, AC1Q3AFU, LS-14287, ...
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Disease relevance of N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-N-ethyl-propane-1,3-diamine

  • The selective metabolic deactivation of ICR compounds may be related to the findings of previous carcinogenicity studies (1-3) which showed the induction of lung adenomas following i.v. but not i.p. administration of ICR 170 [1].
  • Preparations of Chinese hamster ovary (CHO) cells decreased the genotoxicity of 3 ICR compounds (ICR 191, ICR 191-OH and ICR 170-OH), while they did not affect the genotoxicity of ICR 170 in the Salmonella reversion test nor in a DNA-repair test in E. coli [2].
  • In xeroderma pigmentosum (XP) C cells there was less repair after UV plus ICR-170 than after each treatment separately; whereas there was an additive effect after UV plus 4NQO and no inhibition of loss of endonuclease sensitive sites [3].
  • Aberration analysis revealed that both the mouse lymphoma and CHO cells responded to the clastogenicity of the compounds (except for ICR 170 which was not positive in CHO cells) and that neither cell line was clearly more sensitive than the other to the clastogens tested [4].
  • Of several chemicals tested on the elimination of plasmids from Escherichia coli K-12, the compound designated ICR-170 was most effective, applied at 100 mu g/ml, the effect being comparable to that of acriflavin [5].

High impact information on N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-N-ethyl-propane-1,3-diamine


Biological context of N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-N-ethyl-propane-1,3-diamine

  • The overall data base demonstrates that ICR-170-induced ad-3 mutations result exclusively from gene/point mutations at the ad-3A and ad-3B loci and not multilocus deletion mutations [8].
  • Comparison of the dose-response curves for the major classes and subclasses of ICR-170-induced ad-3 mutations demonstrates that the gene/point ad-3 mutations and multiple-locus ad-3 mutations with a separate site of recessive lethal damage elsewhere in the genome have different induction kinetics.(ABSTRACT TRUNCATED AT 400 WORDS)[8]
  • ICR-170 was found to increase the reversion frequency by ten- to 15-fold at its LD50, although most of the frameshifts that it induced were single-base insertions outside the microsatellite sequence [9].

Anatomical context of N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-N-ethyl-propane-1,3-diamine

  • The results indicate that in normal human fibroblasts there are different rate limiting steps for removal of chemical and physical damages from DNA and that XP cells have a different repair system for ICR-170, not just a lower level, than normal cells [3].
  • Despite the fact that ICR-170 induces little DNA repair in xeroderma pigmentosum (XP) cells, which are deficient in excision repair, the inhibition of DNA synthesis induced by this agent was less in XP cells than in HeLa cells [10].

Associations of N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-N-ethyl-propane-1,3-diamine with other chemical compounds


Gene context of N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-acridin-9-yl)-N-ethyl-propane-1,3-diamine


  1. Selective deactivation of ICR mutagens as related to their distinctive pulmonary carcinogenicity. De Flora, S., Morelli, A., Zanacchi, P., Bennicelli, C., De Flora, A. Carcinogenesis (1982) [Pubmed]
  2. Relationships between metabolic deactivation of ICR compounds and their differential mutagenicity in bacteria and cultured mammalian cells. De Flora, S., Basso, C., Camoirano, A., Astengo, M., Badolati, G.S. Mutat. Res. (1986) [Pubmed]
  3. DNA excision in repair proficient and deficient human cells treated with a combination of ultraviolet radiation and acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide. Ahmed, F.E., Setlow, R.B. Chem. Biol. Interact. (1980) [Pubmed]
  4. Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci. Moore, M.M., Harrington-Brock, K., Doerr, C.L., Dearfield, K.L. Mutagenesis (1989) [Pubmed]
  5. A study on the effect of certain compound during elimination of plasmids in Escherichia coli. Rytír, V., Hubácek, J., Srogl, M. Folia Microbiol. (Praha) (1975) [Pubmed]
  6. Highly mutable sites for ICR-170-induced frameshift mutations are associated with potential DNA hairpin structures: studies with SUP4 and other Saccharomyces cerevisiae genes. Hampsey, D.M., Koski, R.A., Sherman, F. Mol. Cell. Biol. (1986) [Pubmed]
  7. Suppressible and nonsuppressible +1 G-C base pair insertions induced by ICR-170 at the his4 locus in Saccharomyces cerevisiae. Mathison, L., Culbertson, M.R. Mol. Cell. Biol. (1985) [Pubmed]
  8. Forward-mutation tests on the antitumor agent ICR-170 in Neurospora crassa demonstrate that it induces gene/point mutations in the ad-3 region and an exceptionally high frequency of multiple-locus ad-3 mutations with closely linked sites of recessive lethal damage. de Serres, F.J., Malling, H.V. Mutat. Res. (1994) [Pubmed]
  9. Induction of frameshift mutations in cultured mammalian cells within a transfected sequence containing a poly(dC-dA).poly(dT-dG) microsatellite. Riedinger, K.L., Hanford, M.G., Farber, R.A. Environ. Mol. Mutagen. (1996) [Pubmed]
  10. DNA synthesis inhibition in HeLa cells as a simple test for agents that damage human DNA. Painter, R.B. Journal of environmental pathology and toxicology. (1978) [Pubmed]
  11. Quantification and analysis of reverse mutations at the hgprt locus in Chinese hamster ovary cells. Fuscoe, J.C., O'Neill, J.P., Machanoff, R., Hsie, A.W. Mutat. Res. (1982) [Pubmed]
  12. Effect of N2 on the mutagenic and lethal activities of ICR-170 in Neurospora crassa. Whong, W.Z. Mutat. Res. (1979) [Pubmed]
  13. Azaguanine-resistant mutants induced by several mutagens in a neurospora heterokaryon. Hoffmann, G.R., Malling, H.V. Mutat. Res. (1975) [Pubmed]
  14. Selection in HAT medium is not a reliable method for the study of reversion from 6-thioguanine resistance to sensitivity. Bonatti, S., Di Leonardo, A., Mariani, L., Randazzo, R., Sciandrello, G. Mutat. Res. (1982) [Pubmed]
  15. DNA sequences of frameshift and other mutations induced by ICR-170 in yeast. Ernst, J.F., Hampsey, D.M., Sherman, F. Genetics (1985) [Pubmed]
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