Disease relevance of Niludipin

• Of the calcium channel blockers, nifedipine produced the greatest and niludipine the least reflex tachycardia [1].
• The calcium channel blockers verapamil, diltiazem, nicardipine, and niludipine potentiated the antitumor activities of mitotic poison antitumor agents, such as vincristine, vinblastine, vindesine, VP16-213, and taxol in P388 leukemia cells resistant to vincristine [2].
• Effects of nifedipine and niludipine on ultrastructural changes induced by coronary occlusion in dog hearts [3].
• Treatment of angina pectoris patients with niludipine a new calcium antagonistic drug [4].
• Clinical effectiveness of niludipine in patients with ischemic heart disease [5].

High impact information on Niludipin

• Nisoldipine, niludipine and FR 34235 decreased baroreceptor sensitivity (defined as delta cardiac interval/delta systolic arterial pressure; milliseconds per millimeter of mercury) in a dose-related manner [6].
• We examined the direct effect of ionophore A23187, voltage-sensitive Ca(2+)-channel blockers verapamil, nimodipine, nifedipine, niludipine and calmodulin antagonist trifluoroperazine on progesterone and cGMP levels in 3-day culture of small granulosa cells [7].
• Effects of niludipine (Bay-a-7168) on transmembrane action potentials of rabbit sinus node cells and atrial muscle fibers [8].
• Effects of niludipine (bis(2-propoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedic arboxylate; Bay-a-7168) on isolated rabbit sinus node and right atrial preparations were studied using intracellular microelectrode techniques [8].
• Niludipine prolonged the effective refractory period of atrial muscle fibers by 4--8 msec [8].

Biological context of Niludipin

• Niludipine in concentrations above 1 X 10(-8) M caused dose-dependent changes in the membrane action potentials of the preparations [8].
• With 3 mg/kg p.o. of niludipine a fall of blood pressure was marked at its peak effect attained about 45 min after dosing and lasted about 3 h [9].
• Bay a 7168 lowered systolic and diastolic blood pressures markedly, and decreased heart rate slightly [10].
• 5. In the presence of Bay a 7168, acceleration of glycogenolysis being caused by coronary artery ligation, was not detected [10].
• Niludipine (60 mg) increased cardiac output (CO; 5.13 to 7.56 l/min), stroke volume (79.0 to 107 ml/beat), and decreased total peripheral resistance (22.3 to 13.6 mmHg/l/min) [11].

Anatomical context of Niludipin

• Results suggest that niludipine is a useful antianginal drug in the management of coronary artery disease patients [4].
• The ischemic myocardium was prepared by partial occlusion of the left circumflex coronary artery, and niludipine was given i.v. at a dose of 5 micrograms/kg [12].
• Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas [13].
• The results suggest that niludipine appears to be beneficial in reducing systolic and diastolic work of the left ventricle during pacing induced angina without a significant change in total coronary sinus blood flow [14].

Associations of Niludipin with other chemical compounds

• The effect of nifedipine and niludipine on ischemic myocardial pH was studied [15].
• Effects of six dihydropyridine derivatives (nifedipine, nisoldipine, nitrendipine, nicardipine, nimodipine and niludipine) and hydralazine on blood pressure and heart rate in spontaneously hypertensive rats (SHR) were studied in comparison with those in normotensive rats (NR) [16].
• A new calcium channel blocker, niludipine, was administered intravenously to nine patients with coronary artery disease in order to investigate its effects on left ventricular systolic and diastolic function, coronary sinus blood flow, and myocardial lactate metabolism [14].
• Prior administration of propranolol (30 mg/kg p.o.) greatly prevented an increase in heart rate accompanying the fall of blood pressure produced by 3 mg/kg p.o. of niludipine but was of no effect on the antihypertensive action [9].
• The effect of pretreatment with 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine carbonic acid-bis(2-propoxyethyl) ester (niludipine, Bay a 7168) (10 microgram/kg i.v.) on myocardial metabolic response to coronary artery ligation was studied in dogs anesthetized with pentobarbital [10].

Gene context of Niludipin

• To study the effects of two Ca antagonists, nifedipine and niludipine, on insulin and glucagon secretion, experiments were performed using an in situ local circulation of the canine pancreas [13].

Analytical, diagnostic and therapeutic context of Niludipin

• Oral administration of from 60--120 mg niludipine daily for 4--8 weeks, resulted in the following: 1 [4].
• 6. Changes in the levels of myocardial carbohydrate intermediates being caused by coronary artery ligation, were not modified by pretreatment with Bay a 7168 [10].
• 5. In the investigators' final overall assessment, including the evaluation of ECG changes, niludipine was rated effective for 20 out of 27 patients (74.1%) [4].

References