Disease relevance of FLUOCORTOLONE

• METHODS: Patients were treated with high-dose UVA1R (10 days, 130 J/cm2/day; n = 20), topically with fluocortolone (10 days, 1 x daily; n = 17), or with UVA-UVB therapy (10 days, 1 x daily, minimal erythema dose-dependent; n = 16) [1].
• Fluocortolone is a potent corticosteroid used orally for the treatment of rheumatic diseases, asthma, and immunosuppression [2].
• Two of the pregnancies were spontaneous, and 12 were generated by hMG/hCG and fluocortolone, with or without pretreatment with GnRH-a. Twelve healthy babies were generated by 10 gestations, 3 ended in spontaneous abortions (23%), and 1 is ongoing [3].
• To prevent abortion relapses, 16 of them were treated with acetylsalicylic acid (50 mg x 2/day) and/or fluocortolone (20 mg/day for 5 days/week) [4].
• Long-term efficacy and toxicity of cyclosporin A + fluocortolone + methotrexate in the treatment of rheumatoid arthritis [5].

Psychiatry related information on FLUOCORTOLONE

• Hydrocortisone and fluocortolone induced a substantial reduction of rapid eye movement sleep [6].

High impact information on FLUOCORTOLONE

• PATIENTS/METHODS: Thirteen patients with erythrodermic CTCL (stages III-IVb) were treated with chlorambucil and fluocortolone therapy (chlorambucil 10-12 mg day-1 for 3 days and fluocortolone, first day 75 mg, second day 50 mg and third day 25 mg) as primary therapy in an uncontrolled pilot study [7].
• Serum levels of eosinophil cationic protein and the blood eosinophil count were significantly reduced after high-dose UVA1 or fluocortolone, but not UVA-UVB therapy [1].
• Pharmacokinetic/pharmacodynamic modeling of cortisol suppression after oral administration of fluocortolone [2].
• A clinical study of nine healthy volunteers was conducted to determine the pharmacokinetics and cortisol suppression after administration of single oral doses of 20 mg, 50 mg, and 100 mg of fluocortolone [2].
• The results of the study characterize the kinetics of unbound fluocortolone for the first time [8].

Chemical compound and disease context of FLUOCORTOLONE

• A multicentre, between-patient, comparative trial was carried out by nine dermatologists in the Federal Republic of Germany to compare the efficacy and tolerability of 0.05 halometasone ointment with those of an ointment, containing 0.25% fluocortolone + 0.25% fluocortolone caproate, in patients with psoriasis vulgaris [9].

Biological context of FLUOCORTOLONE

• Specific pathogen free guinea pigs were treated with varying dosis of fluocortolone for 15 days [10].
• Fluocortolone treatment at doses of 0.05 to 10 mg/kg resulted in a dose-dependent rise of intraocular pressure (IOP) [11].

Associations of FLUOCORTOLONE with other chemical compounds

• CONCLUSIONS: We conclude that pulse chemotherapy with chlorambucil and fluocortolone is effective and safe in the treatment of erythrodermic CTCL and should be considered as an alternative to the classical Winkelmann treatment scheme [7].
• Determination of fluocortolone pivalate and fluocortolone hexanoate in suppositories using reverse-phase HPLC [12].

Analytical, diagnostic and therapeutic context of FLUOCORTOLONE

• Each subject was given 20 mg fluocortolone orally and the plasma concentrations of total and unbound fluocortolone in multiple samples obtained during the following 24 h were determined by HPLC and equilibrium dialysis [13].
• After intravenous injection the plasma levels of fluocortolone decreased biexponentially with half-lives of 9 +/- 5 min and 1.3 +/- 0.3 h [14].

References