The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CDH17  -  cadherin 17, LI cadherin (liver-intestine)

Homo sapiens

Synonyms: CDH16, Cadherin-17, HPT-1, HPT1, Intestinal peptide-associated transporter HPT-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CDH17


Psychiatry related information on CDH17

  • Anti-phospho-threonine 212/phospho-serine 214 (HPT-1), anti-phospho-threonine 231/phospho-serine 235 (HPT-101) and their biotinylated derivatives were shown to be sensitive markers for the immunohistochemical detection of neuropathological alterations during Alzheimer's disease [4].

High impact information on CDH17

  • The amino acid sequence deduced from the complementary DNA sequence of the cloned gene indicated that this transport-associated protein shares several conserved structural elements with the cadherin superfamily of calcium-dependent, cell-cell adhesion proteins [5].
  • Features such as a large repertoire of homotypically interacting cadherins, rapid assembly and disassembly, and a connection to a force-generating actin cytoskeleton make cadherin-mediated junctions ideal structures for the execution of complex changes in cell and tissue morphology during development [6].
  • A major form of animal cell-cell adhesion results from the dynamic association of cadherin molecules, cytosolic catenins and actin microfilaments [7].
  • Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo) [8].
  • Thus, CD8(+)/CD103(+) tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through alpha(E)beta(7)-E-cadherin interactions [9].

Chemical compound and disease context of CDH17


Biological context of CDH17


Anatomical context of CDH17


Associations of CDH17 with chemical compounds


Physical interactions of CDH17

  • Furthermore, the nm23-H1 (-)/E-cadherin (+) coexpression profile was coupled to decreased E-cadherin immunohistochemical protein detection (grade II) in 21% of the cases examined [19].

Co-localisations of CDH17


Regulatory relationships of CDH17


Other interactions of CDH17


Analytical, diagnostic and therapeutic context of CDH17


  1. R-cadherin influences cell motility via Rho family GTPases. Johnson, E., Theisen, C.S., Johnson, K.R., Wheelock, M.J. J. Biol. Chem. (2004) [Pubmed]
  2. LI-cadherin: a marker of gastric metaplasia and neoplasia. Grötzinger, C., Kneifel, J., Patschan, D., Schnoy, N., Anagnostopoulos, I., Faiss, S., Tauber, R., Wiedenmann, B., Gessner, R. Gut (2001) [Pubmed]
  3. Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. Wang, X.Q., Luk, J.M., Leung, P.P., Wong, B.W., Stanbridge, E.J., Fan, S.T. Clin. Cancer Res. (2005) [Pubmed]
  4. Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. Härtig, W., Lehmann, J., Stieler, J., Singer, D., Grosche, J., Arendt, T., Hoffmann, R. Neuroreport (2006) [Pubmed]
  5. Association of intestinal peptide transport with a protein related to the cadherin superfamily. Dantzig, A.H., Hoskins, J.A., Tabas, L.B., Bright, S., Shepard, R.L., Jenkins, I.L., Duckworth, D.C., Sportsman, J.R., Mackensen, D., Rosteck, P.R. Science (1994) [Pubmed]
  6. Cadherin-catenin proteins in vertebrate development. Lien, W.H., Klezovitch, O., Vasioukhin, V. Curr. Opin. Cell Biol. (2006) [Pubmed]
  7. Regulation of cell-cell junctions by the cytoskeleton. Mège, R.M., Gavard, J., Lambert, M. Curr. Opin. Cell Biol. (2006) [Pubmed]
  8. Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Halbleib, J.M., Nelson, W.J. Genes Dev. (2006) [Pubmed]
  9. {alpha}E{beta}7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. Floc'h, A.L., Jalil, A., Vergnon, I., Chansac, B.l.e. .M., Lazar, V., Bismuth, G., Chouaib, S., Mami-Chouaib, F. J. Exp. Med. (2007) [Pubmed]
  10. The role of alpha E beta 7 integrin (CD103) and E-cadherin in epidermotropism in cutaneous T-cell lymphoma. Dietz, S.B., Whitaker-Menezes, D., Lessin, S.R. J. Cutan. Pathol. (1996) [Pubmed]
  11. Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. Wang, X.Q., Luk, J.M., Garcia-Barcelo, M., Miao, X., Leung, P.P., Ho, D.W., Cheung, S.T., Lam, B.Y., Cheung, C.K., Wong, A.S., Lau, S.S., So, M.T., Yu, W.C., Cai, Q., Liu, K.S., Hui, C.K., Lau, G.K., Poon, R.T., Wong, J., Fan, S.T. Clin. Cancer Res. (2006) [Pubmed]
  12. Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway. Bennett, F.C., Harvey, K.F. Curr. Biol. (2006) [Pubmed]
  13. Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. Ko, S., Chu, K.M., Luk, J.M., Wong, B.W., Yuen, S.T., Leung, S.Y., Wong, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  14. Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. Takamura, M., Ichida, T., Matsuda, Y., Kobayashi, M., Yamagiwa, S., Genda, T., Shioji, K., Hashimoto, S., Nomoto, M., Hatakeyama, K., Ajioka, Y., Sakamoto, M., Hirohashi, S., Aoyagi, Y. Cancer Lett. (2004) [Pubmed]
  15. Hydrophilic photolabelling of glycopeptides from the murine liver-intestine (LI) cadherin recognition domain. Heiner, S., Detert, H., Kuhn, A., Kunz, H. Bioorg. Med. Chem. (2006) [Pubmed]
  16. TNF-{alpha} increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Angelini, D.J., Hyun, S.W., Grigoryev, D.N., Garg, P., Gong, P., Singh, I.S., Passaniti, A., Hasday, J.D., Goldblum, S.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  17. Altered expression of beta-catenin/E-cadherin in meningiomas. Brunner, E.C., Romeike, B.F., Jung, M., Comtesse, N., Meese, E. Histopathology (2006) [Pubmed]
  18. Histamine alters cadherin-mediated sites of endothelial adhesion. Winter, M.C., Kamath, A.M., Ries, D.R., Shasby, S.S., Chen, Y.T., Shasby, D.M. Am. J. Physiol. (1999) [Pubmed]
  19. High frequency of concomitant nm23-H1 and E-cadherin transcriptional inactivation in primary non-inheriting colorectal carcinomas. Garinis, G.A., Manolis, E.N., Spanakis, N.E., Patrinos, G.P., Peros, G., Menounos, P.G. J. Mol. Med. (2003) [Pubmed]
  20. CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. Ko, S., Chu, K.M., Luk, J.M., Wong, B.W., Yuen, S.T., Leung, S.Y., Wong, J. J. Pathol. (2005) [Pubmed]
  21. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Hinoi, T., Lucas, P.C., Kuick, R., Hanash, S., Cho, K.R., Fearon, E.R. Gastroenterology (2002) [Pubmed]
  22. Identification of liver-intestine cadherin in hepatocellular carcinoma--a potential disease marker. Wong, B.W., Luk, J.M., Ng, I.O., Hu, M.Y., Liu, K.D., Fan, S.T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  23. Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues. Herrera-Ruiz, D., Wang, Q., Gudmundsson, O.S., Cook, T.J., Smith, R.L., Faria, T.N., Knipp, G.T. AAPS PharmSci (2001) [Pubmed]
  24. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Chalmers, I.J., Höfler, H., Atkinson, M.J. Genomics (1999) [Pubmed]
WikiGenes - Universities