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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

P1Ehs1  -  protein, Chr 1, NIEHS 1

Mus musculus

Synonyms: protein E
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Disease relevance of P1Ehs1


High impact information on P1Ehs1


Biological context of P1Ehs1

  • We have thus identified two classes of MAbs, those which recognize the native form and those which recognize the denatured form of protein E. The latter may be useful for the analysis of sites probably involved in protein folding and oligomerization [10].
  • Coronavirus small envelope protein E has two known biological functions: it plays a pivotal role in virus envelope formation, and the murine coronavirus E protein induces apoptosis in E protein-expressing cultured cells [11].
  • The gene of TBE virus protein E was inserted into the pcDNA3 plasmid (designated as pcDNA3/E-TBE) [12].

Anatomical context of P1Ehs1


Associations of P1Ehs1 with chemical compounds

  • To study these strains, we sequenced cDNA fragments of protein E gene from six archival formalin-fixed brain samples [16].

Analytical, diagnostic and therapeutic context of P1Ehs1

  • Each of the peptides was tested by ELISA for reactivity with 19 protein E-specific MAbs raised against TBE virus strain Neudoerfl [10].
  • One polypeptide [mol. wt. 58 X 10(3) (58K)] is related to the major envelope protein E, but the identity of the other is at present unknown, even though it is a major immunogen in experimental infections and vaccinations [17].


  1. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Cano, A., Pérez-Moreno, M.A., Rodrigo, I., Locascio, A., Blanco, M.J., del Barrio, M.G., Portillo, F., Nieto, M.A. Nat. Cell Biol. (2000) [Pubmed]
  2. Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H. Alitalo, A., Meri, T., Chen, T., Lankinen, H., Cheng, Z.Z., Jokiranta, T.S., Seppälä, I.J., Lahdenne, P., Hefty, P.S., Akins, D.R., Meri, S. J. Immunol. (2004) [Pubmed]
  3. Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site. Mandl, C.W., Allison, S.L., Holzmann, H., Meixner, T., Heinz, F.X. J. Virol. (2000) [Pubmed]
  4. Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E. Raamsman, M.J., Locker, J.K., de Hooge, A., de Vries, A.A., Griffiths, G., Vennema, H., Rottier, P.J. J. Virol. (2000) [Pubmed]
  5. Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Roman, C., Platero, J.S., Shuman, J., Calame, K. Genes Dev. (1990) [Pubmed]
  6. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. Weaver, B.A., Bonday, Z.Q., Putkey, F.R., Kops, G.J., Silk, A.D., Cleveland, D.W. J. Cell Biol. (2003) [Pubmed]
  7. Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro. Zettl, K.S., Sjaastad, M.D., Riskin, P.M., Parry, G., Machen, T.E., Firestone, G.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice. Rumyantsev, A.A., Murphy, B.R., Pletnev, A.G. J. Virol. (2006) [Pubmed]
  9. Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein e in flavivirus assembly. Orlinger, K.K., Hoenninger, V.M., Kofler, R.M., Mandl, C.W. J. Virol. (2006) [Pubmed]
  10. Assessment of the antigenic structure of tick-borne encephalitis virus by the use of synthetic peptides. Holzmann, H., Utter, G., Norrby, E., Mandl, C.W., Kunz, C., Heinz, F.X. J. Gen. Virol. (1993) [Pubmed]
  11. Membrane topology of coronavirus E protein. Maeda, J., Repass, J.F., Maeda, A., Makino, S. Virology (2001) [Pubmed]
  12. A study of systems for delivering antigens and plasmid DNA for intranasal immunization against tick-borne encephalitis virus. Goncharova, E.P., Ryzhikov, A.B., Bulychev, L.E., Sizov, A.A., Lebedev, L.R., Poryvaev, V.D., Karpenko, L.I., Il'ichev, A.A. Wien. Klin. Wochenschr. (2002) [Pubmed]
  13. E-cadherin is required for the correct formation of autotypic adherens junctions of the outer mesaxon but not for the integrity of myelinated fibers of peripheral nerves. Young, P., Boussadia, O., Berger, P., Leone, D.P., Charnay, P., Kemler, R., Suter, U. Mol. Cell. Neurosci. (2002) [Pubmed]
  14. Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis. Heinz, F.X., Allison, S.L., Stiasny, K., Schalich, J., Holzmann, H., Mandl, C.W., Kunz, C. Vaccine (1995) [Pubmed]
  15. A recombinant Fab neutralizes dengue virus in vitro. Thullier, P., Lafaye, P., Mégret, F., Deubel, V., Jouan, A., Mazié, J.C. J. Biotechnol. (1999) [Pubmed]
  16. Tick-borne encephalitis with hemorrhagic syndrome, Novosibirsk region, Russia, 1999. Ternovoi, V.A., Kurzhukov, G.P., Sokolov, Y.V., Ivanov, G.Y., Ivanisenko, V.A., Loktev, A.V., Ryder, R.W., Netesov, S.V., Loktev, V.B. Emerging Infect. Dis. (2003) [Pubmed]
  17. Antigenic variation among members of the tick-borne encephalitis complex. Stephenson, J.R., Lee, J.M., Wilton-Smith, P.D. J. Gen. Virol. (1984) [Pubmed]
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