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Gene Review

LZTS1  -  leucine zipper, putative tumor suppressor 1

Homo sapiens

Synonyms: F37, F37/esophageal cancer-related gene-coding leucine-zipper motif, FEZ1, Fez1
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Disease relevance of LZTS1


High impact information on LZTS1


Biological context of LZTS1


Anatomical context of LZTS1


Associations of LZTS1 with chemical compounds

  • Expression of FEZ1 was not restored by 5-aza-2'-deoxycytidine and trichostatin A [11].
  • Unlike L1, however, FEZ-1 appeared to be monomeric in gel permeation chromatography experiments and exhibited a distinctive substrate specificity with a marked preference for cephalosporins and meropenem [12].
  • The replacement of phenylalanine at 37 (F37) position with methionine caused drastical loss of IgG and IgE binding activities of human sera derived from egg allergic patients as well as disruption of the alpha-helix structure which comprises a part of the IgG and IgE epitopes [13].
  • Substituting glycine at 32 position in conjunction with F37 showed a synergistic effect of decreasing antigenicity [13].
  • Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of 6.1+/-0.7muM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs [14].

Other interactions of LZTS1

  • We report here the cloning, gene organization, cDNA sequence characterization and expression analysis of LAPSER1, an LZTS1-related gene [15].
  • Hypermethylation of the CpG island flanking the Fez1/Lzts1 promoter was evident in six of the eight cell lines examined as well as in the normal control [16].

Analytical, diagnostic and therapeutic context of LZTS1


  1. Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Nonaka, D., Fabbri, A., Roz, L., Mariani, L., Vecchione, A., Moore, G.W., Tavecchio, L., Croce, C.M., Sozzi, G. Cancer Res. (2005) [Pubmed]
  2. Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. Cabeza-Arvelaiz, Y., Sepulveda, J.L., Lebovitz, R.M., Thompson, T.C., Chinault, A.C. Oncogene (2001) [Pubmed]
  3. Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas. Ono, K., Uzawa, K., Nakatsuru, M., Shiiba, M., Mochida, Y., Tada, A., Bukawa, H., Miyakawa, A., Yokoe, H., Tanzawa, H. Int. J. Oncol. (2003) [Pubmed]
  4. Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk. Hawkins, G.A., Mychaleckyj, J.C., Zheng, S.L., Faith, D.A., Kelly, B., Isaacs, S.D., Wiley, K.E., Chang, B.L., Ewing, C.M., Bujnovszky, P., Bleecker, E.R., Walsh, P.C., Meyers, D.A., Isaacs, W.B., Xu, J. Cancer Genet. Cytogenet. (2002) [Pubmed]
  5. FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells. Vecchione, A., Ishii, H., Baldassarre, G., Bassi, P., Trapasso, F., Alder, H., Pagano, F., Gomella, L.G., Croce, C.M., Baffa, R. Am. J. Pathol. (2002) [Pubmed]
  6. FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. Ishii, H., Vecchione, A., Murakumo, Y., Baldassarre, G., Numata, S., Trapasso, F., Alder, H., Baffa, R., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Ishii, H., Baffa, R., Numata, S.I., Murakumo, Y., Rattan, S., Inoue, H., Mori, M., Fidanza, V., Alder, H., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer. Knowles, M.A., Aveyard, J.S., Taylor, C.F., Harnden, P., Bass, S. Cancer Lett. (2005) [Pubmed]
  9. Mutation and expression analysis of LZTS1 in ovarian cancer. Arnold, J.M., Choong, D.Y., Lai, J., Campbell, I.G., Chenevix-Trench, G. Cancer Lett. (2006) [Pubmed]
  10. Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases. Vecchione, A., Galetti, T.P., Gardiman, M., Ishii, H., Giarnieri, E., Pagano, F., Gomella, L.G., Croce, C.M., Baffa, R. BMC urology [electronic resource]. (2004) [Pubmed]
  11. Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. Toyooka, S., Fukuyama, Y., Wistuba, I.I., Tockman, M.S., Minna, J.D., Gazdar, A.F. Clin. Cancer Res. (2002) [Pubmed]
  12. The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases. Boschi, L., Mercuri, P.S., Riccio, M.L., Amicosante, G., Galleni, M., Frère, J.M., Rossolini, G.M. Antimicrob. Agents Chemother. (2000) [Pubmed]
  13. Reduction of antigenicity and allergenicity of genetically modified egg white allergen, ovomucoid third domain. Mine, Y., Sasaki, E., Zhang, J.W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  14. Inhibitors of the FEZ-1 metallo-beta-lactamase. Liénard, B.M., Horsfall, L.E., Galleni, M., Frère, J.M., Schofield, C.J. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
  15. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. Cabeza-Arvelaiz, Y., Thompson, T.C., Sepulveda, J.L., Chinault, A.C. Oncogene (2001) [Pubmed]
  16. Fez1/lzts1 alterations in gastric carcinoma. Vecchione, A., Ishii, H., Shiao, Y.H., Trapasso, F., Rugge, M., Tamburrino, J.F., Murakumo, Y., Alder, H., Croce, C.M., Baffa, R. Clin. Cancer Res. (2001) [Pubmed]
  17. Molecular genetics of bladder cancer: targets for diagnosis and therapy. Baffa, R., Letko, J., McClung, C., LeNoir, J., Vecchione, A., Gomella, L.G. J. Exp. Clin. Cancer Res. (2006) [Pubmed]
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