The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cysltr1  -  cysteinyl leukotriene receptor 1

Mus musculus

Synonyms: BB147369, CysLT1R, CysLTR1, Cyslt1, Cyslt1r, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cysltr1


High impact information on Cysltr1


Chemical compound and disease context of Cysltr1


Biological context of Cysltr1


Anatomical context of Cysltr1


Associations of Cysltr1 with chemical compounds


Other interactions of Cysltr1


Analytical, diagnostic and therapeutic context of Cysltr1


  1. Cysteinyl leukotriene receptors CysLT1 and CysLT2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice. Zhang, Y.J., Zhang, L., Ye, Y.L., Fang, S.H., Zhou, Y., Zhang, W.P., Lu, Y.B., Wei, E.Q. Acta Pharmacol. Sin. (2006) [Pubmed]
  2. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Beller, T.C., Friend, D.S., Maekawa, A., Lam, B.K., Austen, K.F., Kanaoka, Y. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. The mast cell and the cysteinyl leukotrienes. Austen, K.F. Novartis Found. Symp. (2005) [Pubmed]
  4. Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Saito, H., Morikawa, H., Howie, K., Crawford, L., Baatjes, A.J., Denburg, E., Cyr, M.M., Denburg, J.A. Immunology (2004) [Pubmed]
  5. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Maekawa, A., Kanaoka, Y., Lam, B.K., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. Prinz, I., Gregoire, C., Mollenkopf, H., Aguado, E., Wang, Y., Malissen, M., Kaufmann, S.H., Malissen, B. J. Immunol. (2005) [Pubmed]
  7. A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung. Okunishi, K., Dohi, M., Nakagome, K., Tanaka, R., Yamamoto, K. J. Immunol. (2004) [Pubmed]
  8. Cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma. Machida, I., Matsuse, H., Kondo, Y., Kawano, T., Saeki, S., Tomari, S., Obase, Y., Fukushima, C., Kohno, S. J. Immunol. (2004) [Pubmed]
  9. Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice. Yu, G.L., Wei, E.Q., Wang, M.L., Zhang, W.P., Zhang, S.H., Weng, J.Q., Chu, L.S., Fang, S.H., Zhou, Y., Chen, Z., Zhang, Q., Zhang, L.H. Brain Res. (2005) [Pubmed]
  10. Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. Yu, G.L., Wei, E.Q., Zhang, S.H., Xu, H.M., Chu, L.S., Zhang, W.P., Zhang, Q., Chen, Z., Mei, R.H., Zhao, M.H. Pharmacology (2005) [Pubmed]
  11. The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model. Muz, M.H., Deveci, F., Bulut, Y., Ilhan, N., Yekeler, H., Turgut, T. Exp. Mol. Med. (2006) [Pubmed]
  12. Ribavirin and cysteinyl leukotriene-1 receptor blockade as treatment for severe bronchiolitis. Bonville, C.A., Rosenberg, H.F., Domachowske, J.B. Antiviral Res. (2006) [Pubmed]
  13. Montelukast modulates lung CysLT(1) receptor expression and eosinophilic inflammation in asthmatic mice. Zhang, Y.J., Zhang, L., Wang, S.B., Shen, H.H., Wei, E.Q. Acta Pharmacol. Sin. (2004) [Pubmed]
  14. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. Maekawa, A., Austen, K.F., Kanaoka, Y. J. Biol. Chem. (2002) [Pubmed]
  15. Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Mancuso, P., Nana-Sinkam, P., Peters-Golden, M. Infect. Immun. (2001) [Pubmed]
  16. Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death. Sheng, W.W., Li, C.T., Zhang, W.P., Yuan, Y.M., Hu, H., Fang, S.H., Zhang, L., Wei, E.Q. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  17. In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity. Sarau, H.M., Foley, J.J., Schmidt, D.B., Martin, L.D., Webb, E.F., Tzimas, M.N., Breton, J.J., Chabot-Fletcher, M., Underwood, D.C., Hay, D.W., Kingsbury, W.D., Chambers, P.A., Pendrak, I., Jakas, D.R., Sathe, G.M., Van Horn, S., Daines, R.A., Griswold, D.E. Prostaglandins Leukot. Essent. Fatty Acids (1999) [Pubmed]
  18. In vivo characterization of zymosan-induced mouse peritoneal inflammation. Rao, T.S., Currie, J.L., Shaffer, A.F., Isakson, P.C. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  19. Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes. Mollerup, J., Jørgensen, S.T., Hougaard, C., Hoffmann, E.K. Biochim. Biophys. Acta (2001) [Pubmed]
  20. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. Thivierge, M., Stankova, J., Rola-Pleszczynski, M. J. Allergy Clin. Immunol. (2006) [Pubmed]
  21. Cysteinyl leukotriene receptors. Evans, J.F. Prostaglandins Other Lipid Mediat. (2002) [Pubmed]
  22. Pathophysiological role of mast cells in collagen-induced arthritis: Study with a cysteinyl leukotriene receptor antagonist, montelukast. Shiota, N., Shimoura, K., Okunishi, H. Eur. J. Pharmacol. (2006) [Pubmed]
  23. Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. Hazel, B.A., O'Connor, A., Niculescu, R., Kalf, G.F. Environ. Health Perspect. (1996) [Pubmed]
  24. Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells. Lambert, I.H. J. Membr. Biol. (1989) [Pubmed]
  25. Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. Goldhill, J., Morris, S.C., Maliszewski, C., Urban, J.F., Funk, C.D., Finkelman, F.D., Shea-Donohue, T. Am. J. Physiol. (1997) [Pubmed]
  26. Enantioselective activation of the peroxisome proliferator-activated receptor. Boie, Y., Adam, M., Rushmore, T.H., Kennedy, B.P. J. Biol. Chem. (1993) [Pubmed]
  27. Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. Goldhill, J.M., Finkelman, F.D., Morris, S.C., Shea-Donohue, T. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  28. Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals. Jain, N.K., Kulkarni, S.K., Singh, A. Eur. J. Pharmacol. (2001) [Pubmed]
  29. Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. Kelley, M., Groth-Watson, A., Knoble, D., Kornbrust, D. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1994) [Pubmed]
  30. Stereospecific HPLC method for the quantitation of the enantiomers of MK-0571, a potent leukotriene D4 receptor antagonist, in biological specimens. Lee, L.L., Zacchei, A.G. Chirality. (1991) [Pubmed]
WikiGenes - Universities