The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Trpv5  -  transient receptor potential cation...

Rattus norvegicus

Synonyms: CaT2, Calcium transporter 2, Cat2, ECaC1, Ecac, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Trpv5


High impact information on Trpv5


Biological context of Trpv5

  • CaT1 shows homology (75% amino acid sequence identity) to the apical calcium channel ECaC recently cloned from vitamin D-responsive cells of rabbit kidney and is structurally related to the capsaicin receptor and the TRP family of ion channels [3].
  • ECaC1 co-localized with the Ca2+ binding protein calbindin-D(28K) in the beta-cells [1].

Anatomical context of Trpv5

  • Similar to the alkaline earth metal ions, application of Cd(2+) elicited inward current in CaT2-expressing oocytes with a K(m) of 1.3 mm [2].
  • Calcium-related proteins include the calcium transporters 1 and 2 (CaT1 and CaT2), plasma membrane Ca2+-ATPase 1b (PMCA1b), and calbindin-D9k and -D28k [4].
  • Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal [5].
  • Expression of the novel epithelial Ca2+ channel ECaC1 in rat pancreatic islets [1].
  • These observations provide evidence for the first time of an ECaC-based Ca2+ transport system in SCCD that could maintain the low Ca2+ concentration in vestibular endolymph [5].

Associations of Trpv5 with chemical compounds

  • In conclusion, CaT2 may participate in calcium entry into the cells of the distal convoluted tubule and connecting segment of the nephron, where active reabsorption of calcium takes place via the transcellular route [2].

Regulatory relationships of Trpv5

  • Further, vitamin D receptor was also expressed in SCCD and it was found by quantitative RT-PCR that incubation for 24 h with 1,25-dihydroxyvitamin D3 upregulated the expression of ECaC1, calbindin-D9k, and calbindin-D28k [5].

Other interactions of Trpv5


  1. Expression of the novel epithelial Ca2+ channel ECaC1 in rat pancreatic islets. Janssen, S.W., Hoenderop, J.G., Hermus, A.R., Sweep, F.C., Martens, G.J., Bindels, R.J. J. Histochem. Cytochem. (2002) [Pubmed]
  2. A rat kidney-specific calcium transporter in the distal nephron. Peng, J.B., Chen, X.Z., Berger, U.V., Vassilev, P.M., Brown, E.M., Hediger, M.A. J. Biol. Chem. (2000) [Pubmed]
  3. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. Peng, J.B., Chen, X.Z., Berger, U.V., Vassilev, P.M., Tsukaguchi, H., Brown, E.M., Hediger, M.A. J. Biol. Chem. (1999) [Pubmed]
  4. Differential expression of uterine calcium transporter 1 and plasma membrane Ca2+ ATPase 1b during rat estrous cycle. Kim, H.J., Lee, G.S., Ji, Y.K., Choi, K.C., Jeung, E.B. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  5. Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Yamauchi, D., Raveendran, N.N., Pondugula, S.R., Kampalli, S.B., Sanneman, J.D., Harbidge, D.G., Marcus, D.C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
WikiGenes - Universities