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Gene Review

Trpv6  -  transient receptor potential cation...

Rattus norvegicus

Synonyms: CaT1, Calcium transport protein 1, ECaC2, Ecac2, Epithelial calcium channel 2, ...
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Disease relevance of Trpv6


High impact information on Trpv6


Biological context of Trpv6


Anatomical context of Trpv6


Associations of Trpv6 with chemical compounds

  • Fe(3+), Fe(2+), Mn(2+), and Zn(2+) have no significant effects at 100 microM on CaT1-mediated Ca(2+) transport [9].
  • CaT1 is also permeant to Sr(2+) and Ba(2+) (but not Mg(2+)), although the currents evoked by Sr(2+) and Ba(2+) are much smaller than those evoked by Ca(2+) [9].
  • The trivalent cations Gd(3+) and La(3+) and the divalent cations Cu(2+), Pb(2+), Cd(2+), Co(2+), and Ni(2+) (each at 100 microM) do not evoke currents themselves, but inhibit CaT1-mediated Ca(2+) transport [9].
  • To evaluate the sex steroids involved in uterine CaT1 mRNA regulation, 17beta-estradiol (E2) and/or progesterone (P4) were injected into immature rats [10].
  • Calcium transport, however, was inhibited by vanadate in a concentration-dependent fashion with a K0.5 of 10 microM [13].

Regulatory relationships of Trpv6

  • Together, these results suggest that CaT1 is regulated by P4 at diestrus via a PR-dependent pathway [10].
  • Calcium transport by the Ca2(+)-pumping ATPase in rat duodenal basolateral-enriched membrane vesicles was stimulated by synthetic calbindin-D9k in a similar fashion to the purified natural protein [14].

Other interactions of Trpv6


Analytical, diagnostic and therapeutic context of Trpv6

  • Calcium transport by the Na+/Ca2+ exchanger was measured in plasma membranes vesicles purified from rat brain and in primary rat cortical cell culture [17].
  • Northern-blot analysis of intestinal ribonucleic acid of vitamin D-deficient rats given seven daily injections of vehicle or 100 ng 1,25(OH)(2)D(3) or 19-norD(2) revealed that 19-norD(2) was less potent than 1,25(OH)(2)D(3) in stimulating expression of CaT1, Calbindin D9k and PMCA1 [18].


  1. Calcium transport and translocation of adenine nucleotides in mitochondria from Morris hepatoma 3924A. Eboli, M.L., Malmström, K., Galeotti, T., López-Alarcón, L., Carafoli, E. Cancer Res. (1979) [Pubmed]
  2. Calcium transport in erythrocytes of rats with spontaneous hypertension. Orlov, S.N., Pokudin, N.I., Postnov, Y.V. J. Hypertens. (1988) [Pubmed]
  3. Calcium transport by plasma membranes from a glucose-responsive rat insulinoma. Hoenig, M., Culberson, L.H., Ferguson, D.C. Endocrinology (1991) [Pubmed]
  4. Effects of long-term treatment with trandolapril on sarcoplasmic reticulum function of cardiac muscle in rats with chronic heart failure following myocardial infarction. Yamaguchi, F., Sanbe, A., Takeo, S. Br. J. Pharmacol. (1998) [Pubmed]
  5. Studies of subcellular control factors in hearts of uremic rats. Penpargkul, S., Bhan, A.K., Scheuer, J. J. Lab. Clin. Med. (1976) [Pubmed]
  6. Calcium transport abnormality in uremic rat brain synaptosomes. Fraser, C.L., Sarnacki, P., Arieff, A.I. J. Clin. Invest. (1985) [Pubmed]
  7. Calcium transport of Plasmodium chabaudi-infected erythrocytes. Tanabe, K., Mikkelsen, R.B., Wallach, D.F. J. Cell Biol. (1982) [Pubmed]
  8. Electron probe analysis of calcium transport by small intestine. Warner, R.R., Coleman, J.R. J. Cell Biol. (1975) [Pubmed]
  9. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. Peng, J.B., Chen, X.Z., Berger, U.V., Vassilev, P.M., Tsukaguchi, H., Brown, E.M., Hediger, M.A. J. Biol. Chem. (1999) [Pubmed]
  10. Differential expression of uterine calcium transporter 1 and plasma membrane Ca2+ ATPase 1b during rat estrous cycle. Kim, H.J., Lee, G.S., Ji, Y.K., Choi, K.C., Jeung, E.B. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  11. Calcium transport in small intestine during pregnancy and lactation. Halloran, B.P., DeLuca, H.F. Am. J. Physiol. (1980) [Pubmed]
  12. Calcium transport in dentinogenesis. An experimental study in the rat incisor odontoblast. Lundgren, T. Swedish dental journal. Supplement. (1992) [Pubmed]
  13. Novel ATP-dependent calcium transport component from rat liver plasma membranes. The transporter and the previously reported (Ca2+-Mg2+)-ATPase are different proteins. Lin, S.H. J. Biol. Chem. (1985) [Pubmed]
  14. Stimulation of intestinal basolateral membrane calcium-pump activity by recombinant synthetic calbindin-D9k and specific mutants. Walters, J.R., Howard, A., Charpin, M.V., Gniecko, K.C., Brodin, P., Thulin, E., Forsén, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  15. Calcium transport by sarcoplasmic reticulum of vascular smooth muscle: II. Effects of calmodulin and calmodulin inhibitors. Stout, M.A., Silver, P.J. J. Cell. Physiol. (1992) [Pubmed]
  16. Calcium transport in isolated bone cells. III. Effects of parathyroid hormone and cyclic 3',5'-AMP. Dziak, R., Stern, P.H. Endocrinology (1975) [Pubmed]
  17. Zinc inhibits Ca2+ transport by rat brain NA+/Ca2+ exchanger. Colvin, R.A. Neuroreport (1998) [Pubmed]
  18. Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport. Brown, A.J., Finch, J., Slatopolsky, E. J. Lab. Clin. Med. (2002) [Pubmed]
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