Gene Review:
Alox8 - arachidonate 8-lipoxygenase
Mus musculus
Synonyms:
15-LOX-2, 15-LOX-B, 15-lipoxygenase 2, 8-LOX, 8S-LOX, ...
- An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Kim, E., Rundhaug, J.E., Benavides, F., Yang, P., Newman, R.A., Fischer, S.M. Oncogene (2005)
- Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. Schneider, C., Strayhorn, W.D., Brantley, D.M., Nanney, L.B., Yull, F.E., Brash, A.R. J. Invest. Dermatol. (2004)
- Leukotriene A synthase activity of purified mouse skin arachidonate 8-lipoxygenase expressed in Escherichia coli. Qiao, N., Takahashi, Y., Takamatsu, H., Yoshimoto, T. Biochim. Biophys. Acta (1999)
- A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Coffa, G., Brash, A.R. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. Shappell, S.B., Olson, S.J., Hannah, S.E., Manning, S., Roberts, R.L., Masumori, N., Jisaka, M., Boeglin, W.E., Vader, V., Dave, D.S., Shook, M.F., Thomas, T.Z., Funk, C.D., Brash, A.R., Matusik, R.J. Cancer Res. (2003)
- Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene. Kim, E., Muga, S.J., Fischer, S.M. J. Biol. Chem. (2004)
- Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. Jisaka, M., Kim, R.B., Boeglin, W.E., Brash, A.R. J. Biol. Chem. (2000)
- Arachidonate 8(S)-lipoxygenase. Fürstenberger, G., Marks, F., Krieg, P. Prostaglandins Other Lipid Mediat. (2002)
- Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. Jisaka, M., Boeglin, W.E., Kim, R.B., Brash, A.R. Arch. Biochem. Biophys. (2001)
- 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes. Muga, S.J., Thuillier, P., Pavone, A., Rundhaug, J.E., Boeglin, W.E., Jisaka, M., Brash, A.R., Fischer, S.M. Cell Growth Differ. (2000)
- Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. Jisaka, M., Kim, R.B., Boeglin, W.E., Nanney, L.B., Brash, A.R. J. Biol. Chem. (1997)