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Gene Review

fliL  -  flagellar basal body-associated protein FliL

Borrelia burgdorferi B31

 
 
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Disease relevance of BB0279

  • Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants [1].
  • We propose that certain factors within the spirochete localize at the flagellar motors at one end of the cell to effect this asymmetry [1].
  • METHODS: Synovial specimens obtained at synovectomy from 26 patients with antibiotic treatment-resistant Lyme arthritis and from 10 control subjects were tested for B burgdorferi DNA using 3 primer-probe sets that target genes encoding outer surface proteins A or B or a flagellar protein (P41) of the spirochete [2].
  • In all groups studied, the 41-kDa flagellar protein and a relatively minor 93-kDa protein (p93) were the most commonly recognized antigens in patients with acute and chronic disease due to B. burgdorferi [3].
  • We used PCR amplification to search for B. burgdorferi outer surface protein OspA-specific sequences in DNA obtained from lesional skin biopsies on Finnish patients with clinically suspect erythema chronicum migrans, lymphocytoma, morphea, or with diverse skin manifestations and persistent high antibodies to B. burgdorferi flagellar antigen [4].
 

High impact information on BB0279

  • We reasoned that if chemotaxis were essential for asymmetrical rotation of the flagellar bundles, and if the flagellar motors at both cell ends were identical, inactivation of the two cheA genes should result in cells that constantly flex [1].
  • Five serum specimens from patients with late manifestations of Lyme disease and borrelia-specific monoclonal antibody H9724 reacted with an epitope in the central region of the flagellar protein (amino acids 205 to 226), which is heterologous to the amino acid sequences of other bacterial flagellins [5].
  • Prognostic B-cell epitopes on the flagellar protein of Borrelia burgdorferi [5].
  • Sodium dodecyl sulfate treatment of spirochetes at a concentration of 0.03% resulted in an outer envelope (OE) fraction in the supernatant and a protoplasmic cylinder (PC) flagellar fraction in the pellet [6].
  • Most descriptions of the B. burgdorferi flagellar filaments indicate that these organelles consist of only one flagellin protein (FlaB) [7].
 

Chemical compound and disease context of BB0279

  • Purified flagellar protein (p41) of Borrelia burgdorferi (strain B31) was subjected to chemical cleavage with hydroxylamine or proteolysis with V8 protease, endoproteinase Asp-N, or alpha-chymotrypsin [8].
 

Biological context of BB0279

  • FliH and fliI of Borrelia burgdorferi are similar to flagellar and virulence factor export proteins of other bacteria [9].
  • We investigated 12 patients with elevated serum Bb antibody levels, with a median follow-up time of 11 years, during which 3 of the 12 still exhibited intrathecal antibody production of antibodies against Bb flagellar antigen, and 2 of the 3 had normal serum Bb antibodies [10].
  • Most of the proteins (outer surface proteins, flagellar proteins and other uncertain location proteins) have a strong antigenic variability [11].
 

Anatomical context of BB0279

 

Analytical, diagnostic and therapeutic context of BB0279

References

  1. Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants. Li, C., Bakker, R.G., Motaleb, M.A., Sartakova, M.L., Cabello, F.C., Charon, N.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis. Carlson, D., Hernandez, J., Bloom, B.J., Coburn, J., Aversa, J.M., Steere, A.C. Arthritis Rheum. (1999) [Pubmed]
  3. The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen. Luft, B.J., Mudri, S., Jiang, W., Dattwyler, R.J., Gorevic, P.D., Fischer, T., Munoz, P., Dunn, J.J., Schubach, W.H. Infect. Immun. (1992) [Pubmed]
  4. Successful amplification of DNA specific for Finnish Borrelia burgdorferi isolates in erythema chronicum migrans but not in circumscribed scleroderma lesions. Ranki, A., Aavik, E., Peterson, P., Schauman, K., Nurmilaakso, P. J. Invest. Dermatol. (1994) [Pubmed]
  5. Prognostic B-cell epitopes on the flagellar protein of Borrelia burgdorferi. Schneider, T., Lange, R., Rönspeck, W., Weigelt, W., Kölmel, H.W. Infect. Immun. (1992) [Pubmed]
  6. Isolation of antigenic components from the Lyme disease spirochete: their role in early diagnosis. Coleman, J.L., Benach, J.L. J. Infect. Dis. (1987) [Pubmed]
  7. Structure and expression of the FlaA periplasmic flagellar protein of Borrelia burgdorferi. Ge, Y., Li, C., Corum, L., Slaughter, C.A., Charon, N.W. J. Bacteriol. (1998) [Pubmed]
  8. Mapping the major antigenic domains of the native flagellar antigen of Borrelia burgdorferi. Jiang, W., Luft, B.J., Schubach, W., Dattwyler, R.J., Gorevic, P.D. J. Clin. Microbiol. (1992) [Pubmed]
  9. FliH and fliI of Borrelia burgdorferi are similar to flagellar and virulence factor export proteins of other bacteria. Ge, Y., Old, I., Saint Girons, I., Yelton, D.B., Charon, N.W. Gene (1996) [Pubmed]
  10. Long-term findings in patients with facial palsy and antibodies against Borrelia burgdorferi. Roberg, M., Forsberg, P., Frydén, A., Hederstedt, B., Hydén, D., Odkvist, L. Scand. J. Infect. Dis. (1994) [Pubmed]
  11. Antigenic and genetic structure of Borrelia burgdorferi. Gutiérrez Fernández, J., Rodríguez Fernández, M., Nuñez Murillo, F., Maroto Vela, M.C. Microbios (1997) [Pubmed]
  12. Isolation and partial characterization of Borrelia burgdorferi inner and outer membranes by using isopycnic centrifugation. Bledsoe, H.A., Carroll, J.A., Whelchel, T.R., Farmer, M.A., Dorward, D.W., Gherardini, F.C. J. Bacteriol. (1994) [Pubmed]
  13. Analysis of T lymphocytes cloned from the synovial fluid and blood of a patient with Lyme arthritis. Yssel, H., Nakamoto, T., Schneider, P., Freitas, V., Collins, C., Webb, D., Mensi, N., Soderberg, C., Peltz, G. Int. Immunol. (1990) [Pubmed]
  14. Human cord blood contains an IGM antibody to the 41KD flagellar antigen of Borrelia burgdorferi. Cooke, W.D., Orr, A.S., Wiseman, B.L., Rouse, S.B., Murray, W.C., Ranck, S.G. Scand. J. Immunol. (1993) [Pubmed]
  15. Lyme borreliosis: host responses to Borrelia burgdorferi. Szczepanski, A., Benach, J.L. Microbiol. Rev. (1991) [Pubmed]
  16. The flagellar cytoskeleton of the spirochetes. Wolgemuth, C.W., Charon, N.W., Goldstein, S.F., Goldstein, R.E. J. Mol. Microbiol. Biotechnol. (2006) [Pubmed]
  17. Serodiagnosis of Lyme disease: accuracy of a two-step approach using a flagella-based ELISA and immunoblotting. Johnson, B.J., Robbins, K.E., Bailey, R.E., Cao, B.L., Sviat, S.L., Craven, R.B., Mayer, L.W., Dennis, D.T. J. Infect. Dis. (1996) [Pubmed]
  18. The decrease in FlaA observed in a flaB mutant of Borrelia burgdorferi occurs posttranscriptionally. Motaleb, M.A., Sal, M.S., Charon, N.W. J. Bacteriol. (2004) [Pubmed]
  19. Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis. Magnarelli, L.A., Fikrig, E., Berland, R., Anderson, J.F., Flavell, R.A. J. Clin. Microbiol. (1992) [Pubmed]
 
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