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Gene Review

ADD3  -  adducin 3 (gamma)

Homo sapiens

Synonyms: ADDL, Adducin-like protein 70, Gamma-adducin
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Disease relevance of ADD3


High impact information on ADD3


Biological context of ADD3

  • CONCLUSIONS: The interaction of ADD1 and ADD3 gene variants in humans is statistically associated with variation in blood pressure, suggesting the presence of epistatic effects among these loci [5].
  • Moreover, human ADD3 amino acid sequence presents 91.9% of identity compared to rat sequence [7].
  • The human ADD3 gene spans over 20 kb and is composed of at least 13 introns and 14 exons covering the entire coding region [7].
  • Adducin is a heterodymeric cytoskeleton protein, the 3 subunits of which are encoded by genes (ADD1, ADD2, ADD3) mapping to 3 different chromosomes [8].
  • From a human fetal-brain cDNA library we isolated a novel human cDNA, termed human adducin-like 70 (gene symbol ADDL), whose predicted amino acid sequence showed a high degree of homology to adducins [9].

Anatomical context of ADD3

  • The early expression of ADD3 suggests that it may have a role in erythroblasts but is replaced by ADD2 in later stages of erythropoiesis [6].
  • Whereas ADD1 is ubiquitously distributed, ADD3 is more expressed in kidney medulla and cortex than in fetal kidney, while in adult liver it is less abundant than in fetal liver [10].
  • Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin [9].
  • The presence of high affinity ADDL binding proteins in hippocampus and frontal cortex but not cerebellum parallels the regional specificity of AD pathology and suggests involvement of a toxin receptor-mediated mechanism [11].

Associations of ADD3 with chemical compounds

  • Sesaminol glucoside (50-250microg/ml) also effectively decreased Abeta1-42 and ADDL form of Abeta1-42 as well as the combination of H2O2 with FeSO4-induced cell damages [12].

Analytical, diagnostic and therapeutic context of ADD3

  • In this work we describe the development of a dot-blot immunoassay to measure ADDL at the femtomole level, its use in defining the time course of ADDL formation, and its use in determining the presence of ADDLs in the hAPP transgenic mouse brain [13].


  1. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique. Romana, S.P., Radford-Weiss, I., Ben Abdelali, R., Schluth, C., Petit, A., Dastugue, N., Talmant, P., Bilhou-Nabera, C., Mugneret, F., Lafage-Pochitaloff, M., Mozziconacci, M.J., Andrieu, J., Lai, J.L., Terre, C., Rack, K., Cornillet-Lefebvre, P., Luquet, I., Nadal, N., Nguyen-Khac, F., Perot, C., Van den Akker, J., Fert-Ferrer, S., Cabrol, C., Charrin, C., Tigaud, I., Poirel, H., Vekemans, M., Bernard, O.A., Berger, R. Leukemia (2006) [Pubmed]
  2. Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans. Cwynar, M., Staessen, J.A., Tichá, M., Nawrot, T., Citterio, L., Kuznetsova, T., Wojciechowska, W., Stolarz, K., Filipovský, J., Kawecka-Jaszcz, K., Grodzicki, T., Struijker-Boudier, H.A., Thijs, L., Van Bortel, L.M., Bianchi, G. J. Hypertens. (2005) [Pubmed]
  3. NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15). Lahortiga, I., Vizmanos, J.L., Agirre, X., Vázquez, I., Cigudosa, J.C., Larrayoz, M.J., Sala, F., Gorosquieta, A., Perez-Equiza, K., Calasanz, M.J., Odero, M.D. Cancer Res. (2003) [Pubmed]
  4. Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. van de Water, B., Tijdens, I.B., Verbrugge, A., Huigsloot, M., Dihal, A.A., Stevens, J.L., Jaken, S., Mulder, G.J. J. Biol. Chem. (2000) [Pubmed]
  5. Role of the adducin family genes in human essential hypertension. Lanzani, C., Citterio, L., Jankaricova, M., Sciarrone, M.T., Barlassina, C., Fattori, S., Messaggio, E., Serio, C.D., Zagato, L., Cusi, D., Hamlyn, J.M., Stella, A., Bianchi, G., Manunta, P. J. Hypertens. (2005) [Pubmed]
  6. Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2. Yenerel, M.N., Sundell, I.B., Weese, J., Bulger, M., Gilligan, D.M. Exp. Hematol. (2005) [Pubmed]
  7. Genomic organization of the human gamma adducin gene. Citterio, L., Azzani, T., Duga, S., Bianchi, G. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. Adducin polymorphism: detection and impact on hypertension and related disorders. Bianchi, G., Ferrari, P., Staessen, J.A. Hypertension (2005) [Pubmed]
  9. Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin. Katagiri, T., Ozaki, K., Fujiwara, T., Shimizu, F., Kawai, A., Okuno, S., Suzuki, M., Nakamura, Y., Takahashi, E., Hirai, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  10. Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants. Citterio, L., Tizzoni, L., Catalano, M., Zerbini, G., Bianchi, G., Barlassina, C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  11. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Klein, W.L. Neurochem. Int. (2002) [Pubmed]
  12. Effect of sesaminol glucosides on beta-amyloid-induced PC12 cell death through antioxidant mechanisms. Lee, S.Y., Ha, T.Y., Son, D.J., Kim, S.R., Hong, J.T. Neurosci. Res. (2005) [Pubmed]
  13. Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening. Chang, L., Bakhos, L., Wang, Z., Venton, D.L., Klein, W.L. J. Mol. Neurosci. (2003) [Pubmed]
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