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MeSH Review

Kidney Medulla

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Disease relevance of Kidney Medulla


High impact information on Kidney Medulla


Biological context of Kidney Medulla


Anatomical context of Kidney Medulla


Associations of Kidney Medulla with chemical compounds

  • This study is aimed both at characterizing an ATPase activity in rat kidney equivalent to the proton pump described in bovine kidney medulla and at localizing this enzyme along the nephron [20].
  • However, a probe to the NH2-terminal region was fully protected only by brain and adrenal medullary RNA indicating the likelihood of one or more isozyme(s) divergent in this region in the kidney papilla [21].
  • Biosynthesis of prostaglandins in rabbit kidney medulla. Properties of prostaglandin synthase [22].
  • These results are discussed in the light of our former hypothesis that arachidonic acid release from kidney medulla phospholipids might occur through the sequential action of a phospholipase C coupled to diacylglycerol and monoacylglycerol lipases [Fujimoto, Akamatsu, Hattori & Fujita (1984) Biochem. J. 218, 69-74] [23].
  • We have investigated the effects of phospholipase A2 and C on the synthesis of prostaglandin E2 in rabbit kidney medulla and the release of fatty acids from the medulla slices [24].

Gene context of Kidney Medulla

  • A cDNA encoding rat AQP3, a water channel and a member of the MIP family, that is expressed predominantly in kidney medulla and colon was cloned recently [25].
  • Whereas ADD1 is ubiquitously distributed, ADD3 is more expressed in kidney medulla and cortex than in fetal kidney, while in adult liver it is less abundant than in fetal liver [26].
  • After LPS treatment, changes in COX-2 immunoreactivity could be observed in interstitial cells in the kidney medulla and in inner cortical cells in the adrenal gland [27].
  • Both Atp7a and Atp7b are expressed in glomeruli; however, Atp7b is also seen in the kidney medulla [28].
  • In the kidney medulla, GAPDH was concentrated in the basolateral membrane of type A intercalated cells, where it colocalized with the alternatively spliced kidney form of AE1 [29].

Analytical, diagnostic and therapeutic context of Kidney Medulla


  1. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. Uchida, S., Sasaki, S., Furukawa, T., Hiraoka, M., Imai, T., Hirata, Y., Marumo, F. J. Biol. Chem. (1993) [Pubmed]
  2. Endothelin receptor subtypes A and B are up-regulated in an experimental model of acute renal failure. Roubert, P., Gillard-Roubert, V., Pourmarin, L., Cornet, S., Guilmard, C., Plas, P., Pirotzky, E., Chabrier, P.E., Braquet, P. Mol. Pharmacol. (1994) [Pubmed]
  3. Depression of prostaglandin synthetase activity in kidney medulla by Shigella endotoxin injected intravenously. Bhattacherjee, P., Phylactos, A. Biochem. Pharmacol. (1978) [Pubmed]
  4. Prostaglandin endoperoxide synthetase-dependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes. Boyd, J.A., Eling, T.E. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  5. Long-term feeding of corn oil, beef tallow, or menhaden oil and eicosanoid levels in BHE/cdb rats. Bunce, O.R., Abou el-Ela, S.H., Berdanier, C.D. Nutrition (Burbank, Los Angeles County, Calif.) (1992) [Pubmed]
  6. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. Marples, D., Frøkiaer, J., Dørup, J., Knepper, M.A., Nielsen, S. J. Clin. Invest. (1996) [Pubmed]
  7. Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct. Sasaki, S., Fushimi, K., Saito, H., Saito, F., Uchida, S., Ishibashi, K., Kuwahara, M., Ikeuchi, T., Inui, K., Nakajima, K. J. Clin. Invest. (1994) [Pubmed]
  8. Taurine behaves as an osmolyte in Madin-Darby canine kidney cells. Protection by polarized, regulated transport of taurine. Uchida, S., Nakanishi, T., Kwon, H.M., Preston, A.S., Handler, J.S. J. Clin. Invest. (1991) [Pubmed]
  9. An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla. Gluck, S., Al-Awqati, Q. J. Clin. Invest. (1984) [Pubmed]
  10. Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. López-Rodríguez, C., Antos, C.L., Shelton, J.M., Richardson, J.A., Lin, F., Novobrantseva, T.I., Bronson, R.T., Igarashi, P., Rao, A., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. Kuwahara, M., Fushimi, K., Terada, Y., Bai, L., Marumo, F., Sasaki, S. J. Biol. Chem. (1995) [Pubmed]
  12. In vivo osmoregulation of Na/myo-inositol cotransporter mRNA in rat kidney medulla. Yamauchi, A., Nakanishi, T., Takamitsu, Y., Sugita, M., Imai, E., Noguchi, T., Fujiwara, Y., Kamada, T., Ueda, N. J. Am. Soc. Nephrol. (1994) [Pubmed]
  13. The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices. Fujimoto, Y., Tanioka, H., Keshi, I., Fujita, T. Biochem. J. (1983) [Pubmed]
  14. Effect of the aldose reductase inhibitor tolrestat on nerve conduction velocity, Na/K ATPase activity, and polyols in red blood cells, sciatic nerve, kidney cortex, and kidney medulla of diabetic rats. Raccah, D., Coste, T., Cameron, N.E., Dufayet, D., Vague, P., Hohman, T.C. J. Diabetes Complicat. (1998) [Pubmed]
  15. Accumulation of glycerophosphocholine (GPC) by renal cells: osmotic regulation of GPC:choline phosphodiesterase. Zablocki, K., Miller, S.P., Garcia-Perez, A., Burg, M.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  16. Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro. Jo, I., Harris, H.W., Amendt-Raduege, A.M., Majewski, R.R., Hammond, T.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Solubilization of the [8-lysine]vasopressin receptor and adenylate cyclase from pig kidney plasma membranes. Roy, C., Rajerison, R., Bockaert, J., Jard, S. J. Biol. Chem. (1975) [Pubmed]
  18. Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). Tse, C.M., Levine, S.A., Yun, C.H., Montrose, M.H., Little, P.J., Pouyssegur, J., Donowitz, M. J. Biol. Chem. (1993) [Pubmed]
  19. The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. Luo, G., D'Souza, R., Hogue, D., Karsenty, G. J. Bone Miner. Res. (1995) [Pubmed]
  20. Characterization of N-ethylmaleimide-sensitive proton pump in the rat kidney. Localization along the nephron. Ait-Mohamed, A.K., Marsy, S., Barlet, C., Khadouri, C., Doucet, A. J. Biol. Chem. (1986) [Pubmed]
  21. Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain. Bentley, J.K., Kadlecek, A., Sherbert, C.H., Seger, D., Sonnenburg, W.K., Charbonneau, H., Novack, J.P., Beavo, J.A. J. Biol. Chem. (1992) [Pubmed]
  22. Biosynthesis of prostaglandins in rabbit kidney medulla. Properties of prostaglandin synthase. Tai, H.H., Tai, C.L., Hollander, C.S. Biochem. J. (1976) [Pubmed]
  23. Effect of diarachidonin on prostaglandin E2 synthesis in rabbit kidney medulla slices. Fujimoto, Y., Uno, H., Kagen, C., Ueno, T., Fujita, T. Biochem. J. (1985) [Pubmed]
  24. Stimulation of prostaglandin E2 synthesis by exogenous phospholipase A2 and C in rabbit kidney medulla slices. Fujimoto, Y., Akamatsu, N., Hattori, A., Fujita, T. Biochem. J. (1984) [Pubmed]
  25. Structure and chromosomal localization of a human water channel (AQP3) gene. Ishibashi, K., Sasaki, S., Saito, F., Ikeuchi, T., Marumo, F. Genomics (1995) [Pubmed]
  26. Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants. Citterio, L., Tizzoni, L., Catalano, M., Zerbini, G., Bianchi, G., Barlassina, C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  27. Cyclooxygenase-1 and cyclooxygenase-2 expression in rat kidney and adrenal gland after stimulation with systemic lipopolysaccharide: in situ hybridization and immunocytochemical studies. Ichitani, Y., Holmberg, K., Maunsbach, A.B., Haeggström, J.Z., Samuelsson, B., De Witt, D., Hökfelt, T. Cell Tissue Res. (2001) [Pubmed]
  28. Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b. Moore, S.D., Cox, D.W. Nephron (2002) [Pubmed]
  29. Colocalization of GAPDH and band 3 (AE1) proteins in rat erythrocytes and kidney intercalated cell membranes. Ercolani, L., Brown, D., Stuart-Tilley, A., Alper, S.L. Am. J. Physiol. (1992) [Pubmed]
  30. Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. Mudge, G.H., Gemborys, M.W., Duggin, G.G. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  31. Matrix Gla protein gene expression is elevated during postnatal development. Zhao, J., Nishimoto, S.K. Matrix Biol. (1996) [Pubmed]
  32. Immunocytochemical and functional characterization of Na+ conductance in adult alveolar pneumocytes. Matalon, S., Kirk, K.L., Bubien, J.K., Oh, Y., Hu, P., Yue, G., Shoemaker, R., Cragoe, E.J., Benos, D.J. Am. J. Physiol. (1992) [Pubmed]
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