The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Col11a2  -  collagen, type XI, alpha 2

Mus musculus

Synonyms: Collagen alpha-2(XI) chain
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Col11a2


High impact information on Col11a2

  • Sox9 binds to essential sequences in the Col2a1 and collagen alpha2(XI) gene (Col11a2) chondrocyte-specific enhancers and can activate these enhancers in non-chondrocytic cells [4].
  • Mice with a targeted disruption of Col11a2 also were shown to have hearing loss [5].
  • Here, we demonstrate that NT2 functions as a negative regulator of Col11a2 [2].
  • In situ hybridization analysis of developing mouse cartilage showed that NT2 mRNA is highly expressed by hypertrophic chondrocytes but is minimally expressed by resting and proliferating chondrocytes, in an inverse correlation with the expression patterns of Col11a2 [2].
  • We investigated a tissue-specific transcriptional enhancer in the first intron of the alpha2(XI) collagen gene (Col11a2) [6].

Biological context of Col11a2


Anatomical context of Col11a2

  • The greater epithelial ridge appeared to be the main, if not only, source of mRNA encoding Col11a1 and Col11a2 in the tectorial membrane [1].
  • RESULTS: Similar, diffuse expression of Col11a1 and Col11a2 mRNA was first observed in the cochlear duct at embryonic Day 15.5, with increasingly focal hybridization being noted at postnatal Days 1 and 5 in the greater epithelial ridge and lateral wall of the cochlea [1].
  • To identify a protein factor that bound to the 24-bp sequence of the Col11a2 promoter, we screened a mouse limb bud cDNA expression library in the yeast one-hybrid screening system and obtained the cDNA clone NT2 [2].
  • A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos [8].

Associations of Col11a2 with chemical compounds

  • However, translation of the full-length Col11a2 chain was unable to occur because of the presence of premature termination codons within the inverted neomycin-resistant gene [9].

Physical interactions of Col11a2

  • Gel shift assays showed that NT2 bound a specific sequence within the 24-bp site of the Col11a2 promoter [2].

Regulatory relationships of Col11a2

  • The expression vector for mutant NT2 lacking the KRAB domain failed to inhibit Col11a2 promoter activity [2].

Other interactions of Col11a2


Analytical, diagnostic and therapeutic context of Col11a2


  1. Col11a1 and Col11a2 mRNA expression in the developing mouse cochlea: implications for the correlation of hearing loss phenotype with mutant type XI collagen genotype. Shpargel, K.B., Makishima, T., Griffith, A.J. Acta Otolaryngol. (2004) [Pubmed]
  2. A Krüppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene. Tanaka, K., Tsumaki, N., Kozak, C.A., Matsumoto, Y., Nakatani, F., Iwamoto, Y., Yamada, Y. Mol. Cell. Biol. (2002) [Pubmed]
  3. More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise. Lapveteläinen, T., Hyttinen, M., Lindblom, J., Långsjö, T.K., Sironen, R., Li, S.W., Arita, M., Prockop, D.J., Puustjärvi, K., Helminen, H.J. Osteoarthr. Cartil. (2001) [Pubmed]
  4. Sox9 is required for cartilage formation. Bi, W., Deng, J.M., Zhang, Z., Behringer, R.R., de Crombrugghe, B. Nat. Genet. (1999) [Pubmed]
  5. Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13). McGuirt, W.T., Prasad, S.D., Griffith, A.J., Kunst, H.P., Green, G.E., Shpargel, K.B., Runge, C., Huybrechts, C., Mueller, R.F., Lynch, E., King, M.C., Brunner, H.G., Cremers, C.W., Takanosu, M., Li, S.W., Arita, M., Mayne, R., Prockop, D.J., Van Camp, G., Smith, R.J. Nat. Genet. (1999) [Pubmed]
  6. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene. Liu, Y., Li, H., Tanaka, K., Tsumaki, N., Yamada, Y. J. Biol. Chem. (2000) [Pubmed]
  7. Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. Bridgewater, L.C., Lefebvre, V., de Crombrugghe, B. J. Biol. Chem. (1998) [Pubmed]
  8. A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos. Li, S.W., Arita, M., Kopen, G.C., Phinney, D.G., Prockop, D.J. Matrix Biol. (1998) [Pubmed]
  9. Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED). Li, S.W., Takanosu, M., Arita, M., Bao, Y., Ren, Z.X., Maier, A., Prockop, D.J., Mayne, R. Dev. Dyn. (2001) [Pubmed]
  10. Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and RT1.Hb genes in the rat major histocompatibility complex. Walter, L., Fischer, K., Günther, E. Immunogenetics (1996) [Pubmed]
WikiGenes - Universities